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Exploring link between elevated blood pressure early in life and dementia

Whether elevated blood pressure early in life translates to increased risk of dementia is a question scientists are working to answer.

28 Jan 2020

Research could improve lives of some people with treatment-resistant depression

Beth MacKay knew at a young age that she saw the world differently than many of her friends and family. She thought her pessimism and cynicism were rooted in realism, a proud reminder of her Scottish roots, and not a sign of an underlying medical condition. But, that understanding of herself changed when at the age of 17, she attempted suicide.

28 Jan 2020

Study suggests prenatal origin for ‘young’ Parkinson’s disease

A new study published in the journal Nature Medicine on January 2020 suggests that Parkinson’s disease developing before the age of 50 years could be due to an abnormality in certain brain cells that remains dormant until the age of onset of the disease. It also indicates the potential usefulness of a specific drug to prevent this by correcting the brain cell disorder.

27 Jan 2020

Parkinson's disease may affect brain cells before birth

People who develop Parkinson's disease before age 50 may have been born with disordered brain cells that went undetected for decades, according to new Cedars-Sinai research. The research points to a drug that potentially might help correct these disease processes.

27 Jan 2020

Mysterious large holes in cells linked with sense of taste, Alzheimer's disease, asthma

Many cells are covered with mysterious large holes, pores that have been associated with the sense of taste as well as Alzheimer's disease, depression, and even asthma. Knowing the structure of these varied holes will help researchers better understand this range of associations and provide a blueprint for developing new therapies.

27 Jan 2020

New insights into globular glial tauopathy could aid in the design of better drugs

Tauopathies are a group of neurodegenerative diseases characterized by the accumulation of phospho-tau, in other words tau associated to phosphate groups.

27 Jan 2020

Research unravels consequences of Zika virus attack on neural cells

Previous studies regarding the damage of the Zika virus on the brain had already pointed out the virus's predilection for a certain neural cell: the astrocyte. However, few studies have proposed to identify the infection effects on these cells, as well as their association with developmental alterations, including brain malformations and microcephaly.

27 Jan 2020

Medtronic: RCT demonstrates profound back pain relief with DTM therapy

Medtronic plc today announced three-month results from a large, multicenter randomized controlled trial showing statistically significant (p=0.0009) and superior back pain relief with Differential Target Multiplexed (DTM) Spinal Cord Stimulation (SCS) compared to conventional SCS.

From Medtronic 27 Jan 2020

First glioblastoma patient treated with genetically modified poliovirus at UH

University Hospitals Seidman Cancer Center treated its first patient in a new clinical trial to validate the groundbreaking effects of the poliovirus on glioblastoma, a deadly Grade IV cancer of the brain.

24 Jan 2020

Non-hormonal options are effective in treating menopause symptoms

The classic symptoms of menopause – hot flashes, sleeplessness, and vaginal dryness – have typically been treated with estrogen therapy. Studies published today report that non-hormonal options are effective, too.

24 Jan 2020

Novel technique used to show how electrical impulses travel with high speed in the brain

Researchers from the Netherlands Institute for Neuroscience used a new technique to show how electrical impulses are traveling with high speed in the brain.

24 Jan 2020

Stanford scientists complete first global census of cell surface proteins

Stanford scientists have completed the first global census of diverse proteins sprouting tree-like from the outer membrane of a cell. These cell surface proteins govern how cells interact with one another and how they assemble into tissues and organs such as hearts and brains.

24 Jan 2020

Study sheds light on how norepinephrine release influences the fear-memory formation

Researchers at RIKEN Center for Brain Science have visualized the dynamic processes involving norepinephrine that influence different types of fear-memory formation in a living mouse model.

24 Jan 2020

Researchers observe fast and slow molecular pathways that support memory function

A sustained state of vigilance will generate a different type of memory than a momentary startle, and these differences are linked to distinct signaling molecules in the brains of mice.

24 Jan 2020

Scientists visualize diabetes-related proteins at high resolution

Scientists have examined a key receptor for the first time at high resolution - broadening understanding of how it might function, and opening the door to future improvements in treating conditions such as type 2 diabetes.

24 Jan 2020

Landmark study identifies 102 genes associated with autism risk

In the largest genetic sequencing study of autism spectrum disorder (ASD) to date, researchers have identified 102 genes associated with risk for autism. The study also shows significant progress towards teasing apart the genes associated with ASD from those associated with intellectual disability and developmental delay, conditions which often overlap.

23 Jan 2020

New Distinguished Scholar Award aims to mitigate gender gaps in medical research

The Icahn School of Medicine at Mount Sinai - an international leader in medical and scientific training, biomedical research, and patient care - today announced the recipients of the first-of-its-kind Distinguished Scholar Award, a new annual grant sponsored by the Office of Gender Equity in Science and Medicine. The awards aim to mitigate gender gaps in medical research by supporting researchers with additional project resources while they serve as family caretakers.

23 Jan 2020

Scientists use human stem cells to make pain-killing neurons

Researchers at the University of Sydney have used human stem cells to make pain-killing neurons that provide lasting relief in mice, without side effects, in a single treatment.

23 Jan 2020

Researchers identify novel cellular entry factor for AAV vector types

Researchers led by a team at Massachusetts Eye and Ear have identified a novel cellular entry factor for adeno-associated virus vector (AAV) types--the most commonly used viral vectors for in vivo gene therapy. AAVs are vectors-or vehicles--that are created from a virus that is made harmless by molecular engineering, and have shown promise transporting genetic therapy treatments to affected tissues.

23 Jan 2020

Reelin can reverse the main pathological processes associated with Alzheimer's, other tauopathies

Promoting the signaling pathway of reelin -an essential extracellular protein for the neuronal migration and synaptic plasticity- could be an effective therapeutical strategy to counterbalance the main cognitive, biochemical and behavioral alterations seen in Alzheimer's and other pathologies associated with Tau protein, as shown in a new study with animal models -published in the journal Progress in Neurobiology.

23 Jan 2020