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New technique provides greater understanding of how drugs get in and out of cells in our bodies

A team led by female scientists at the Universities of Bristol and Cambridge has developed an exciting new technique which may lead to a greater understanding of how drugs get in and out of the cells in our bodies. The method identifies the structures that guard the entrance and exits to cells.

15 Jun 2008

Researchers find gamma-secretase modulators being tested for Alzheimer’s work in unexpected and beneficial ways

Researchers at Mayo Clinic, with their national and international collaborators, have discovered how a class of agents now in testing to treat Alzheimer's disease work, and say they may open up an avenue of drug discovery for this disease and others.

11 Jun 2008

Bill should be passed allowing terminally ill access to experimental drugs, journal op-ed states

The case of Sen. Edward Kennedy (D-Mass.), who has been diagnosed with brain cancer, is "identical from a regulatory standpoint to the plight of hundreds of thousands of other Americans" and "shouts to the heavens the humane necessity of urgent reform in the drug approval process to make it work better for people who have serious and terminal diseases," according to a Wall Street Journal opinion piece by Steven Walker and Ronald Trowbridge, chief adviser and adjunct scholar, respectively, of the Abigail Alliance for Better Access to Developmental Drugs.

11 Jun 2008

Scientist deciphers language bacterial cells use to 'talk' to each other - also discovers how to quell their conversation

Understanding the way bacterial cells "talk" to each other could lead to more effective methods for fighting the often persistent and serious infections caused by the biofilms they form, says a Texas A&M University professor of chemical engineering who not only has deciphered their language but also discovered how to quell their conversation.

11 Jun 2008

FDA advisory panel voices concern over risks of HIV vaccine trials in teenagers

An FDA advisory panel on Monday voiced concern over the potential risks of conducting early HIV vaccine trials among teenagers in the U.S., Bloomberg reports. According to the panel, although such trials are justified in countries where HIV/AIDS is spreading more quickly, the risks might not outweigh the benefits in the U.S.

11 Jun 2008

UNAIDS Executive Director Piot to step down

UNAIDS Executive Director Peter Piot will step down from his position when his term is over at the end of the year, United Nations Secretary-General Ban Ki-moon announced on Tuesday at the United Nations 2008 High Level Meeting on AIDS in New York, Reuters reports. Piot has served as UNAIDS executive director since the organization's inception in 1995.

11 Jun 2008

Anti-estrogen drug therapy reduces risk of invasive breast cancer in older women

New analysis of a drug approved for osteoporosis prevention and treatment has provided definitive evidence that the medication is also effective as a breast cancer preventative for certain cancers.

11 Jun 2008

Reduced incidence of invasive breast cancer with Raloxifene among women at increased coronary risk

Women who took raloxifene were less likely to develop invasive estrogen-receptor (ER) positive breast cancer compared with women who did not, according to data from a randomized controlled trial published online June 10 in the Journal of the National Cancer Institute. The drug did not reduce the risk of non-invasive cancer or invasive ER-negative cancers.

11 Jun 2008

Vitamin D, "the heart tranquilizer"

Strong bones, a healthy immune system, protection against some types of cancer: Recent studies suggest there's yet another item for the expanding list of vitamin D benefits. Vitamin D, "the sunshine vitamin," keeps the heart, the body's long-distance runner, fit for life's demands.

11 Jun 2008

Specific immune therapy works for many people with allergies

The German Institute for Quality and Efficiency in Health Care has assessed recent evidence on allergies. It found that the once controversial immune therapy against allergy symptoms can definitely help many people with allergies.

11 Jun 2008

EntreMed receives new patent for 2-Methoxyestradiol analogs

EntreMed, Inc. has announced the issuance of U.S. Patent No. 7,371,741 covering analogs of 2- methoxyestradiol (2ME2).

11 Jun 2008

Three sequencing companies join 1000 Genomes Project

Leaders of the 1000 Genomes Project announced today that three firms that have pioneered development of new sequencing technologies have joined the international effort to build the most detailed map to date of human genetic variation as a tool for medical research. The new participants are: 454 Life Sciences, a Roche company, Branford, Conn.; Applied Biosystems, an Applera Corp. business, Foster City, Calif.; and Illumina Inc., San Diego.

11 Jun 2008

New treatments for lower back pain tested

"This is one of the most frustrating complaints that patients have as they get older." Physicians are testing two drugs approved to treat other conditions to see whether they might also help patients who have severe pain in their lower back and in their legs.

11 Jun 2008

Hope on the horizon for migraine sufferers

A generation of anti-migraine drugs with fewer side effects than existing treatments could be available to sufferers within three years.

11 Jun 2008

Heart Failure 2008 - Congress to address a heart condition whose prevalence is increasing with 'exponential growth'

Heart failure is by far the single biggest reason for acute hospital admission. Around 30 million people in Europe have heart failure and its incidence is still increasing: more cases are being identified, more people are living to an old age, and more are surviving a heart attack but with damage to the heart muscle.

11 Jun 2008

Quick responses to influenza outbreaks reduces illness and death

Influenza outbreaks were shorter and resulted in fewer cases and fewer deaths at long-term care facilities that started residents on preventive antiviral medications within five days of the first case, compared to those that started later, according to a new study in the July 1 issue of Clinical Infectious Diseases, currently available online.

11 Jun 2008