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Mouse models demonstrate new potential target in fight against Alzheimer's disease

Building on research published eight years ago in the journal Chemistry and Biology, Kenneth S. Kosik, Harriman Professor in Neuroscience and co-director of the Neuroscience Research Institute (NRI) at UC Santa Barbara, and his team have now applied their findings to two distinct, well-known mouse models, demonstrating a new potential target in the fight against Alzheimer's and other neurodegenerative diseases.

27 Jun 2013

Ingestion of nanoparticles at typical environmental levels unlikely to cause overt toxicity

Ingestion of commonly encountered nanoparticles at typical environmental levels is unlikely to cause overt toxicity, according to US researchers. Nevertheless there is insufficient evidence to determine whether chronic exposures could lead to subtle alterations in intestinal immune function, protein profiles, or microbial balance.

27 Jun 2013

Janssen, Johnson & Johnson Innovation establish IBD research alliance with Mount Sinai

Janssen Biotech, Inc. and Johnson & Johnson Innovation announced today the establishment of a research alliance with The Icahn School of Medicine at Mount Sinai to advance the scientific understanding of inflammatory bowel disease and the discovery of next generation therapeutic solutions.

27 Jun 2013

Combination therapy with myxoma virus and rapamycin can kill glioblastoma multiforme

A combination of the myxoma virus and the immune suppressant rapamycin can kill glioblastoma multiforme, the most common and deadliest malignant brain tumor, according to Moffitt Cancer Center research.

21 Jun 2013

Microfluidic devices can trap and sort bacteria and viruses in food and water

A new process for making a three-dimensional microstructure that can be used in the analysis of cells could prove useful in counterterrorism measures and in water and food safety concerns.

20 Jun 2013

NUS researchers develop highly realistic 3-D tumor model to track progress of drug therapy

A team of NUS researchers from the Departments of Bioengineering and Orthopaedic Surgery has developed a highly realistic three-dimensional (3-D) tumour model. As it replicates the conditions in the body, it is able to track the effectiveness and progress of drug therapy.

20 Jun 2013

Exposing tissue to low levels of BPA linked to greater incidence of prostate cancer

Exposing developing tissue to low levels of the plastic bisphenol A, commonly known as BPA, is linked to a greater incidence of prostate cancer in tissue grown from human prostate stem cells, a new study finds. The results were presented Monday, June 17, at The Endocrine Society's 95th Annual Meeting in San Francisco.

19 Jun 2013

Bioapplications of nanoparticles: an interview with Dr Catherine Berry, University of Glasgow

These particles are all classed as inorganic particles, which can all be utilised in biomedical applications. They differ in terms of their inherent material and size dependent physiochemical properties, for example, their optical and magnetic properties.

18 Jun 2013

Genmab, ADC Therapeutics agree to develop new antibody-drug conjugate product

Genmab A/S and ADC Therapeutics Sarl, announced today an agreement to develop a new antibody-drug conjugate product combining Genmab's HuMax-TAC antibody and ADC Therapeutics' PBD-based warhead and linker technology.

17 Jun 2013

New collaboration to advance cancer immunotherapy research

The Cancer Research Institute, the Ludwig Institute for Cancer Research and Immune Design, a biotech company focused on immune-based therapies for cancer and other human diseases, today announced that they have signed a collaboration agreement to advance cancer immunotherapy research.

13 Jun 2013

Johns Hopkins expert in brain imaging receives 2013 Paul C. Aebersold Award

A Johns Hopkins expert in brain imaging, Dean F. Wong, M.D., Ph.D., has been honored with the prestigious 2013 Paul C. Aebersold Award for his contributions over the past 30 years in applying basic science to the field of nuclear medicine.

11 Jun 2013

Drug used to control Type II diabetes can help repair spinal cords of mice suffering from inherited disease

A drug used to control Type II diabetes can help repair the spinal cords of mice suffering from the inherited disease adrenoleukodystrophy which, untreated, leads eventually to a paralysis, a vegetative state and death.

10 Jun 2013

Research demonstrates need for development of new treatments for regeneration of nerve cells

Researchers at the University of Michigan have evidence that a single gene controls both halves of nerve cells, and their research demonstrates the need to consider that design in the development of new treatments for regeneration of nerve cells.

5 Jun 2013

Study suggests modulation of "enhancer-directed RNAs" can alter gene expression in living cells

In a pair of distinct but complementary papers, researchers at the University of California, San Diego School of Medicine and colleagues illuminate the functional importance of a relatively new class of RNA molecules.

5 Jun 2013

Bioengineers find innovative ways to grow new cartilage from patient's own stem cells

Cartilage injuries are difficult to repair. Current surgical options generally involve taking a piece from another part of the injured joint and patching over the damaged area, but this approach involves damaging healthy cartilage, and a person's cartilage may still deteriorate with age.

5 Jun 2013

Naurex initiates Phase I trial of NRX-1074 in normal volunteers

Naurex Inc., a clinical-stage company developing innovative treatments to address unmet needs in psychiatry and neurology, today announced that it has begun patient dosing in a Phase I trial of its novel, orally active agent NRX-1074.

4 Jun 2013

Researchers solve long-standing mystery behind dormant disseminated breast tumor cells

The long-standing mystery behind dormant disseminated breast tumor cells and what activates them after years and even decades of latency may have been solved. Researchers with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) have identified the microenvironment surrounding microvasculature - the small blood vessels that transport blood within tissues - as a niche where dormant cancer cells reside. When these blood vessels begin to sprout, the new tips produce molecules that transform dormant cancer cells into metastatic tumors.

4 Jun 2013

Nanoparticle-based immunotherapy for cancer

The German Research Foundation has established a new Collaborative Research Center on "Nanodimensional polymer therapeutics for tumor therapy" (CRC 1066) at Johannes Gutenberg University Mainz and the Max Planck Institute for Polymer Research (MPI-P).

1 Jun 2013

IUPUI assistant professor earns NSF CAREER Award for research on the brain

An assistant professor of computer science at Indiana University-Purdue University Indianapolis has earned the prestigious CAREER Award from the National Science Foundation for research to identify the patterns by which neurons develop and connect to form a brain.

29 May 2013

Study examines effectiveness of VRET on agoraphobia, panic disorder

A number of studies have demonstrated the efficacy of virtual reality exposure therapy in specific phobias, but research in  seriously impaired patients with agoraphobia is lacking.

27 May 2013

in vivo News and Research

Mouse models demonstrate new potential target in fight against Alzheimer's disease

Ingestion of nanoparticles at typical environmental levels unlikely to cause overt toxicity

Janssen, Johnson & Johnson Innovation establish IBD research alliance with Mount Sinai

Combination therapy with myxoma virus and rapamycin can kill glioblastoma multiforme

Microfluidic devices can trap and sort bacteria and viruses in food and water

NUS researchers develop highly realistic 3-D tumor model to track progress of drug therapy

Exposing tissue to low levels of BPA linked to greater incidence of prostate cancer

Bioapplications of nanoparticles: an interview with Dr Catherine Berry, University of Glasgow

Genmab, ADC Therapeutics agree to develop new antibody-drug conjugate product

New collaboration to advance cancer immunotherapy research

Johns Hopkins expert in brain imaging receives 2013 Paul C. Aebersold Award

Drug used to control Type II diabetes can help repair spinal cords of mice suffering from inherited disease

Research demonstrates need for development of new treatments for regeneration of nerve cells

Study suggests modulation of "enhancer-directed RNAs" can alter gene expression in living cells

Bioengineers find innovative ways to grow new cartilage from patient's own stem cells

Naurex initiates Phase I trial of NRX-1074 in normal volunteers

Researchers solve long-standing mystery behind dormant disseminated breast tumor cells

Nanoparticle-based immunotherapy for cancer

IUPUI assistant professor earns NSF CAREER Award for research on the brain

Study examines effectiveness of VRET on agoraphobia, panic disorder

eBook: Using iPSCs models for human disease research and drug discovery eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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