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Novel highly potent SARDs may offer treatment option for advanced prostate cancer, study reports

Novel molecules called selective androgen receptor degraders (SARDs) may offer the next generation of treatment options for advanced prostate cancer, a new industry-sponsored study reports. The results of this research will be presented Saturday, April 1, at ENDO 2017, the 99th annual meeting of the Endocrine Society, in Orlando, Fla.

2 Apr 2017

Investigational compound for treating indolent lymphomas shows positive results in phase II clinical study

Bayer today announced positive data on its investigational compound copanlisib, an intravenous pan-Class I phosphatidylinositol-3-kinase (PI3K) inhibitor with predominant inhibitory activity against PI3K-α and PI3K-δ isoforms.

31 Mar 2017

New report outlines strategies for regenerating retinal ganglion cells

A new report gives recommendations for regenerating retinal ganglion cells (RGCs), crucial neurons in the back of the eye that carry visual information to the brain.

31 Mar 2017

More flexible approach can improve efficiency of preclinical research, study shows

The translation of preclinical research findings into effective treatments continues to deliver unsatisfactory results.

31 Mar 2017

New imaging tool that spots lung infections could help prevent antibiotic overuse

A new imaging tool that rapidly diagnoses bacterial lung infections could help prevent unnecessary use of antibiotics in intensive care units.

30 Mar 2017

UAB chemists design microcapsules for guided drug delivery system to target solid tumors

Chemists at the University of Alabama at Birmingham have designed triple-threat cancer-fighting polymer capsules that bring the promise of guided drug delivery closer to preclinical testing.

30 Mar 2017

LSTM scientists describe new approach to screening potential TB treatments

Scientists from LSTM's Research Centre for Drugs and Diagnostics (RCDD) have described in a paper published today in Scientific Reports, a new way of screening potential treatments for Tuberculosis (TB) which may assist in the identification and prioritisation of new therapies which could potentially reduce the duration of current TB treatment.

29 Mar 2017

New study explores biomechanics of head injury in pediatric patients

The biomechanics of head injury in youths (5 to 18 years of age) have been poorly understood. A new study reported in the Journal of Neurosurgery: Pediatrics set out to determine what biomechanical characteristics predispose youths with concussions to experience transient or persistent postconcussion symptoms.

28 Mar 2017

Public-private collaboration to develop more accurate methods of tracking cancer progression

Columbia University Medical Center and NewYork-Presbyterian, in coordination with the Foundation for the National Institutes of Health Biomarkers Consortium, is launching a three-year research collaboration to develop new methods for analyzing digital images that track a patient's response to cancer therapy.

28 Mar 2017

One-shot vaccine passes key preclinical test in newborn monkey models

Newborns are highly vulnerable to infections and don't respond optimally to most vaccines because their young immune systems typically mount weak antibody responses.

24 Mar 2017

CDM scientist wins IADR award for research in periodontal diseases

On March 22, 2017, the International Association for Dental Research awarded its 2017 Distinguished Scientist Award in Basic Research in Periodontal Disease to Panos N. Papapanou, DDS, PhD, professor and chair of the Section of Oral, Diagnostic and Rehabilitation Sciences of the Columbia University College of Dental Medicine.

24 Mar 2017

PRECISION Panc project aims to develop personalised treatments for pancreatic cancer patients

The development of new treatments for pancreatic cancer is set to be transformed by a network of clinical trials, aiming to find the right trial for the right patient, after a £10 million investment from Cancer Research UK.

23 Mar 2017

Study shows safety of Schwann cell transplantation for treating subacute thoracic spinal cord injury

A Phase I clinical trial that targeted individuals with new onset paraplegia to evaluate the safety of transplanting their own potentially neuroprotective Schwann cells into a trauma-induced spinal cord lesion showed no evidence of adverse effects after 1 year.

22 Mar 2017

Study finds greater risk of suicide following initial episode of self-harm

New findings suggest that American adults who survive deliberate self-harm are at increased risk of suicide in the first year after such an event, indicating a need to direct clinical interventions in the critical 12 months following such episodes.

21 Mar 2017

Study: Treatment window for Fragile X syndrome likely remains open into maturity after childhood

Brain samples from humans show that the treatment window for Fragile X syndrome likely remains open well into maturity after childhood, when previous tests with mice indicated it might close, according to a new Drexel University-led study.

21 Mar 2017

AXT introduces super-resolution fluorescence microscope capable of single molecule imaging in Australia and NZ

AXT are proud to announce that they have recently been appointed the exclusive Australian and New Zealand distributor for Oxford Nanoimaging (ONI). ONI is a UK-based company that has commercialised the “Nanoimager” a revolutionary super-resolution fluorescence microscope capable of single molecule imaging.

From AXT Pty Ltd 21 Mar 2017

Preclinical News and Research

Novel highly potent SARDs may offer treatment option for advanced prostate cancer, study reports

Investigational compound for treating indolent lymphomas shows positive results in phase II clinical study

New report outlines strategies for regenerating retinal ganglion cells

More flexible approach can improve efficiency of preclinical research, study shows

New imaging tool that spots lung infections could help prevent antibiotic overuse

UAB chemists design microcapsules for guided drug delivery system to target solid tumors

LSTM scientists describe new approach to screening potential TB treatments

New study explores biomechanics of head injury in pediatric patients

Public-private collaboration to develop more accurate methods of tracking cancer progression

One-shot vaccine passes key preclinical test in newborn monkey models

CDM scientist wins IADR award for research in periodontal diseases

PRECISION Panc project aims to develop personalised treatments for pancreatic cancer patients

Study shows safety of Schwann cell transplantation for treating subacute thoracic spinal cord injury

Study finds greater risk of suicide following initial episode of self-harm

Study: Treatment window for Fragile X syndrome likely remains open into maturity after childhood

AXT introduces super-resolution fluorescence microscope capable of single molecule imaging in Australia and NZ

Study shows how immune cells drive heart damage in mice

University of Liverpool to establish new research centre to accelerate development of novel antibiotics

Study reveals novel mutations in mucosal melanoma that may pave way for new therapies

CUMC researchers discover common genetic variant that impacts brain aging

Event guide: 4th LNP Formulation & Process Development Summit eBook

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Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

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Bringing real-time analytics to downstream bioprocess monitoring

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Evaluating new approaches for rare disease genomics