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Aspen Biosciences launches Pipeline, the program management software platform specifically for drug discovery. The groundbreaking ‘Pipeline’ Platform is now available for therapeutics development teams

Aspen Biosciences, a leading provider of custom software, and integrations for drug discovery companies, is excited to announce the launch of Pipeline, the drug discovery program management software platform.

9 Feb 2024

New treatment targeting aging cells could offer lasting relief for diabetic macular edema

Targeting senescent cells in the retina with a BCL-xL inhibitor shows promise as a durable treatment for diabetic macular edema, potentially offering long-term visual function improvements.

8 Feb 2024

Selective androgen receptor modulator has anti-tumor effects in ER-positive breast cancer patients

A research paper published today (8 February 2024) in The Lancet Oncology demonstrates that the drug enobosarm, a selective androgen receptor modulator which stimulates the male sex hormone receptor has anti-tumour effects in estrogen receptor positive breast cancer patients.

8 Feb 2024

AI models show promise in predicting heart disease risks, but lack validation

Review highlights the potential of AI models in predicting cardiovascular disease risks but emphasizes the need for independent external validation to ensure their clinical applicability.

8 Feb 2024

Hormonal steroids could make gonorrhea untreatable

You know that package warning that oral birth control won't prevent STIs? Well in the case of gonorrhea, the sexually transmitted bacterium that causes the disease can use those hormones to help it resist antibiotic attacks.

8 Feb 2024

New mouse model illuminates lung cancer's transformation into aggressive variant

Lung tumors called adenocarcinomas sometimes respond to initially effective treatments by transforming into a much more aggressive small cell lung cancer (SCLC) that spreads rapidly and has few options for treatment.

8 Feb 2024

Decoding the differences between two vital RNA transport complexes

Genetic expression, often leading to protein synthesis, requires a complex coordination of molecular machinery across several stages.

8 Feb 2024

Multi-level network analysis provides integrated view of multiple sclerosis

International research led by the Department of Medicine and Life Sciences (MELIS) at Pompeu Fabra University, in collaboration with Hospital del Mar, Hospital Clínic, Charité - Medical University of Berlin, and the universities of Oslo and Genoa, has developed a computational biology tool, based on multi-level network analysis, to achieve an integrated vision of multiple sclerosis.

8 Feb 2024

Never-before-documented genetic disorder causes rare lung disease

The macrophage is one of the body's most important inhabitants. Meaning "big eater" in Greek, this immune cell consumes and digests problematic elements from microbes and cancer cells to dust and debris.

8 Feb 2024

Higher dietary niacin intake linked to lower COPD risk, study finds

Recent research in Scientific Reports reveals a dose-response relationship between dietary niacin intake and reduced prevalence of chronic obstructive pulmonary disease (COPD), suggesting niacin's potential role in mitigating oxidative stress and inflammation in COPD patients.

8 Feb 2024

Immune cells in overdrive: Study finds unbalanced response worsens lung infections

CD4+ T cells have been highlighted in the scientific literature for the important role they play in the immune response to lung infections.

8 Feb 2024

Mitochondrial misfire sparks inflammation

Cells in the human body contain power-generating mitochondria, each with their own mtDNA - a unique set of genetic instructions entirely separate from the cell's nuclear DNA that mitochondria use to create life-giving energy.

8 Feb 2024

New drug targets key mechanism in ALS, protects motor neurons

A new pharmacological inhibitor can intervene in a central cell death mechanism that is responsible for the death of motor neurons and hence important for the progression of the motor neuron disease amyotrophic lateral sclerosis (ALS).

8 Feb 2024

Study advances search for a blood test to identify disease-associated changes in the brain

Researchers in a Johns Hopkins Children's Center-led study that used genetic material from human blood and lab-grown brain cells say they have made progress in developing a blood test to identify disease-associated changes in the brain specifically linked to postpartum depression and other psychiatric and neurological disorders.

8 Feb 2024

Monash-led study unveils potential long-term treatment for lupus

Researchers assessed Smith (Sm)-specific regulatory T cells (Tregs) efficacy in halting lupus nephritis (LN) by engineering and testing epitope-targeted Tregs for systemic lupus erythematosus (SLE) treatment.

8 Feb 2024

ChatGPT passes the nutrition test, but experts remain irreplaceable

ChatGPT offers accurate nutritional advice aligned with international guidelines for managing non-communicable diseases, yet struggles with complex patient scenarios.

7 Feb 2024

Wayne State researchers secure $1.4 million DoD grant for prostate cancer study

A team of researchers from Wayne State University was awarded a $1.4 million, three-year grant from the U.S. Department of Defense for the study, "Cytochrome c acetylation drives prostate cancer aggressiveness and Warburg effect."

7 Feb 2024

Snacking on pistachios may combat metabolic syndrome risk without weight gain

More than half of Americans do not currently meet the daily recommendation of 5–7 ounce equivalents of nuts and seeds per week.

7 Feb 2024

Experimental mRNA vaccine against CMV elicits promising immune responses

An experimental mRNA vaccine against human cytomegalovirus (CMV), a common virus that can infect babies during pregnancy, elicited some of the most promising immune responses to date of any CMV vaccine candidate, according to a study by Weill Cornell Medicine investigators.

7 Feb 2024

Study shines light on partial endothelial-to-mesenchymal transition in the tumor microenvironment

Endothelial-mesenchymal transition (EndoMT, also termed as EndMT), a biological process resulting in the formation of mesenchymal (or lineage-committed) phenotypes from endothelial cells (lining blood vessels), plays a crucial role in tumor progression.

7 Feb 2024