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CB2 receptors might serve as potential therapeutic targets for cerebral ischemia

A new study published in the March issue of The American Journal of Pathology suggests that cortical type 2 cannabinoid (CB2) receptors might serve as potential therapeutic targets for cerebral ischemia.

22 Feb 2013

International nonproprietary name “auriclosene” approved by WHO for NovaBay’s NVC-422

NovaBay® Pharmaceuticals, Inc. (NYSE MKT: NBY), a biotechnology company focused on addressing the large unmet therapeutic needs of the global anti-infective market with first-in-class compounds such as its proprietary Aganocides®, today announced that the World Health Organization (WHO) has approved the international nonproprietary name (INN) “auriclosene” (pronounced awr-rih-CLO-zeen) for the Company’s lead Aganocide® compound NVC-422.

21 Feb 2013

Daclatasvir has two primary modes of action against HCV

A study by researchers from Los Alamos National Laboratory and a multinational team reveals how daclatasvir, a direct-acting antiviral agent in development for the treatment of hepatitis C virus (HCV), targets one of its proteins and causes the fastest viral decline ever seen with anti-HCV drugs - within 12 hours of treatment.

21 Feb 2013

New study reveals how control of brain blood flow develops with age

A new study by Columbia Engineering researchers finds that the infant brain does not control its blood flow in the same way as the adult brain. The paper, which the scientists say could change the way researchers study brain development in infants and children, is published in the February 18 Early Online edition of Proceedings of the National Academy of Sciences (PNAS).

19 Feb 2013

Data from Eleven Biotherapeutics' EBI-005 preclinical study on ocular diseases

Eleven Biotherapeutics, a biopharmaceutical company creating novel and differentiated protein-based biotherapeutics, has published preclinical data in Proceedings of the National Academy of Sciences (PNAS) showing beneficial effects of EBI-005, the first rationally-designed topically administered IL-1 protein for the treatment of ocular diseases.

19 Feb 2013

MILabs VECTor/CT installed by Molecular Imaging Center Antwerp (MICA) in Belgium

MILabs B.V. is pleased to announce that the Molecular Imaging Center Antwerp (MICA) in Belgium has installed a MILabs VECTor/CT to enhance their portfolio of pre-clinical nuclear oncology and neurology imaging and research capabilities.

18 Feb 2013

Study describes pharmacological action of TZDs directly on pancreas

A scientific study published on the journal Diabetes, edited by the American Diabetes Association, describes for the first time the pharmacological action of thiazolidinediones (TZDs) —anti-diabetic drugs— directly on pancreas, the organ which produces insulin.

18 Feb 2013

New materials mimic mussel adhesive proteins for three medical applications

When it comes to sticking power under wet conditions, marine mussels are hard to beat. They can adhere to virtually all inorganic and organic surfaces, sustaining their tenacious bonds in saltwater, including turbulent tidal environments.

18 Feb 2013

Third Rock Ventures announces formation of Jounce Therapeutics

Third Rock Ventures, LLC today announced the formation of Jounce Therapeutics, Inc. with a $47 million Series A financing of the company. Jounce is focused on the discovery and development of first-in-class cancer immunotherapies designed to harness the patient's immune system to seek out and attack cancerous cells and tumors.

15 Feb 2013

Researchers identify new way to influence the vital serotonin signaling system

An interdisciplinary team of researchers from the University of Texas Medical Branch at Galveston and the University of Houston has found a new way to influence the vital serotonin signaling system - possibly leading to more effective medications with fewer side effects.

14 Feb 2013

Researchers describe novel antiviral property of cholesterol-25-hydroxylase

A team of UCLA-led researchers has identified a protein with broad virus-fighting properties that potentially could be used as a weapon against deadly human pathogenic viruses such as HIV, Ebola, Rift Valley Fever, Nipah and others designated "priority pathogens" for national biosecurity purposes by the National Institute of Allergy and Infectious Disease.

13 Feb 2013

Familial psychosis risk linked to prefrontal dopamine dysfunction

People at familial risk for psychosis have attenuated dopamine stress modulation in the ventromedial prefrontal cortex, according to a recent in vivo imaging study.

8 Feb 2013

Milk thistle constituent shows promising skin protection properties

Silibinin, a key component of milk thistle seeds, can help protect against skin damage caused by ultraviolet B radiation, show study findings published in Molecular Carcinogenesis.

8 Feb 2013

Sangamo BioSciences fourth quarter revenues increase to $8.9 million

Sangamo BioSciences, Inc. today reported fourth quarter and full year 2012 financial results and accomplishments.

7 Feb 2013

Tumor suppressor mutant may predict poor outcome in breast cancer

An oncogenic variant of the Krüppel-like family 6 tumor suppressor gene appears to play a role in driving breast cancer metastasis and may be a prognostic marker for poor patient outcome, report researchers.

6 Feb 2013

Detection of B cells may predict graft-versus-host disease

The ability to detect B cells specific to the DEAD box protein may help predict the development of chronic graft-versus-host disease in male recipients of female hematopoietic cells, according to recent findings.

5 Feb 2013

PET with 11C-PIB can positively visualize amyloid deposits in the heart

While amyloid imaging may now be most associated with detecting plaques in the brain, it has the potential to change the way cardiac amyloidosis is diagnosed. According to first-of-its-kind research published in the February issue of The Journal of Nuclear Medicine, positron emission tomography (PET) with 11C-PIB can positively visualize amyloid deposits in the heart.

5 Feb 2013

Bioelectric signals can identify cells that are likely to develop into tumors

Biologists at Tufts University School of Arts and Sciences have discovered a bioelectric signal that can identify cells that are likely to develop into tumors. The researchers also found that they could lower the incidence of cancerous cells by manipulating the electrical charge across cells' membranes.

1 Feb 2013

ALDH1 expression predicts outcome in node-negative rectal cancer

Expression of the cancer stem cell marker aldehyde dehydrogenase 1 is an independent predictor for poor prognosis in node-negative rectal cancer, researchers say.

30 Jan 2013

Breathprints identify lung infections in mice

Researchers working with a mouse model have developed a technique for creating “breathprints” that flag up whether or not the animals have a lung infection.

28 Jan 2013