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University of Bristol-led study could provide new target for treating neurological disorders

Findings, published today [15 Jul] in Nature Communications, reveal the extent a mutation associated with autism and epilepsy plays in impairing a biochemical process in the brain. The study, led by University of Bristol researchers, could provide a new target for treating neurological disorders.

16 Jul 2015

Researchers identify gene that underlies thinking skills

An international team of researchers, including investigators from the University of Mississippi Medical Center, has identified a gene that underlies healthy information processing -- a first step on a complicated road to understand cognitive aging and age-related diseases, such as Alzheimer's disease.

16 Jul 2015

U of T researchers discover new details about key gene involved in ALS

A University of Toronto research team has discovered new details about a key gene involved in ALS, perhaps humanity's most puzzling, intractable disease.

16 Jul 2015

Two chemical compounds effectively inhibit growth of brain cancer cells and breast tumors

Researchers have discovered two chemical compounds that effectively stop the growth of brain cancer cells and breast tumors, opening the way for potential new drugs to be developed.

16 Jul 2015

Gene therapy provides life-long protection to photoreceptor cells in animal model of retinitis pigmentosa

A collaboration between scientists in the UK and the USA has shown that gene therapy can give life-long protection to the light-sensitive photoreceptor cells responsible for colour vision in a mouse model of the most common inherited eye disorder.

15 Jul 2015

Study highlights how KLF15 protein affects availability of nutrients in the body

Case Western Reserve researchers already demonstrated that a single protein plays a pivotal role in the use of nutrients by major organs that allow for the burning of fat during exercise or regulating the heart's contractile and electrical activity. Now they have found a new benefit of Kruppel-like Factor 15 (KLF15) — keeping the body in metabolic balance.

15 Jul 2015

Agilent and BTI collaborate to address a critical need in biopharmaceutical industry

The collaboration will address a gap in analytical tests and standards applied for drugs based on glycoproteins, which now form the majority of approved biopharmaceutical drugs. Current analytical methods for characterizing glycans are time-consuming and difficult to deploy in commercial environments. They are also limited in their ability to detect and analyze minor glycan species.

15 Jul 2015

Efficient, sensitive and robust Chromatin immunoprecipitation methods

Chromatrap®, a business unit of Porvair Sciences, has produced a new 10-page brochure that provides an informative introduction to chromatin immunoprecipitation (ChIP) technology and a detailed comparison of traditional bead based and Chromatrap® solid state ChIP technologies.

From Chromatrap® - Porvair Sciences Ltd 14 Jul 2015

Paul G. Allen Family Foundation announces ADI grants for Alzheimer's disease research

The Paul G. Allen Family Foundation announced today the award of Allen Distinguished Investigator (ADI) grants to five teams of researchers with projects that will open new and innovative avenues of research in Alzheimer's disease by uncovering its elusive biological roots.

14 Jul 2015

Alzheimer's disease may be 'at work' years ahead of actual symptoms, say IU researchers

The best-known genetic variant linked to Alzheimer's disease may be "at work" promoting deposits of plaque in the brain long before any symptoms of the disease can be measured on tests, according to a national research study led by Indiana University School of Medicine investigators.

14 Jul 2015

Researchers discover new mechanism that regulates size of human cells

Every cell in the human body has to be a particular size in order to function correctly. The research group led by Markus Hengstschläger of the Institute for Medical Genetics at the Medical University of Vienna has now discovered a new mechanism that regulates cell size.

14 Jul 2015

Study finds gene linked to age-related obesity, diabetes

Practically everyone gets fatter as they get older, but some people can blame their genes for the extra padding. Researchers have shown that two different mutations in a gene called ankyrin-B cause cells to suck up glucose faster than normal, fattening them up and eventually triggering the type of diabetes linked to obesity.

14 Jul 2015

Stopping cocaine use may lower levels of ET-1 protein that plays key role in coronary artery disease

For people who use cocaine, stopping or reducing cocaine use is associated with decreased levels of endothelin-1 (ET-1)--a protein that plays a key role in the development of coronary artery disease, reports a study in the Journal of Addiction Medicine, the official journal of the American Society of Addiction Medicine.

14 Jul 2015

Biosimilars show promise for children with IBD, but more research needed

Children with inflammatory bowel disease (IBD) who are doing well on specific biological medications should not be switched to recently approved "biosimilar" products, concludes an expert consensus statement of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition.

14 Jul 2015

New understanding of keratin 17 protein could lead to development of better ways to prevent cancer

New research from the Johns Hopkins Bloomberg School of Public Health suggests that the protein keratin 17 - the presence of which is used in the lab to detect and stage various types of cancers - is not just a biomarker for the disease, but may play a critical role in tumor growth.

14 Jul 2015

UM researchers discover new gene behind neurodegenerative conditions

Researchers at the University of Miami have discovered and characterized a previously unknown disease gene linked to the degeneration of optic and peripheral nerve fibers. The study titled "Mutations in SLC25A46, encoding a UGO1-like protein, cause an optic atrophy spectrum disorder" is published in the journal Nature Genetics.

14 Jul 2015

Gene function in the human brain could help reveal basis of autism

UNSW Australia scientists have discovered a link between autism and genetic changes in some segments of DNA that are responsible for switching on genes in the brain.

14 Jul 2015

Researchers identify protein responsible for preserving antibody-producing cells that lead to long-term immunity

Melbourne researchers have identified a protein responsible for preserving the antibody-producing cells that lead to long-term immunity after infection or vaccination.

14 Jul 2015

Researchers discover role of RORC mutations in patients with candidiasis and mycobacteriosis

The discovery of bi-allelic mutations in RORC in patients with candidiasis and mycobacteriosis revealed the pivotal role of RORC in mucocutaneous immunity to Candida and in systemic immunity to Mycobacterium in humans.

13 Jul 2015

Study offers new way to suppress growth factors related to cancer cell proliferation

Cancer cells need life-essential molecules to proliferate. These so-called growth factors are activated by ectodomain shedding of precursor proteins on the outside of the plasma membrane, mainly carried out by three human cleavage enzymes. A pharmaceutical blocking of these enzymes could hinder cancer from growing but would also inhibit other life-essential processes.

13 Jul 2015

G Protein News and Research

University of Bristol-led study could provide new target for treating neurological disorders

Researchers identify gene that underlies thinking skills

U of T researchers discover new details about key gene involved in ALS

Two chemical compounds effectively inhibit growth of brain cancer cells and breast tumors

Gene therapy provides life-long protection to photoreceptor cells in animal model of retinitis pigmentosa

Study highlights how KLF15 protein affects availability of nutrients in the body

Agilent and BTI collaborate to address a critical need in biopharmaceutical industry

Efficient, sensitive and robust Chromatin immunoprecipitation methods

Paul G. Allen Family Foundation announces ADI grants for Alzheimer's disease research

Alzheimer's disease may be 'at work' years ahead of actual symptoms, say IU researchers

Researchers discover new mechanism that regulates size of human cells

Study finds gene linked to age-related obesity, diabetes

Stopping cocaine use may lower levels of ET-1 protein that plays key role in coronary artery disease

Biosimilars show promise for children with IBD, but more research needed

New understanding of keratin 17 protein could lead to development of better ways to prevent cancer

UM researchers discover new gene behind neurodegenerative conditions

Gene function in the human brain could help reveal basis of autism

Researchers identify protein responsible for preserving antibody-producing cells that lead to long-term immunity

Researchers discover role of RORC mutations in patients with candidiasis and mycobacteriosis

Study offers new way to suppress growth factors related to cancer cell proliferation

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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