Preclinical News and Research

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Initial diagnosis of acute kidney injury may be inaccurate for many patients, study suggests

Researchers from Columbia University Medical Center have found that, for many patients, an initial diagnosis of "acute kidney injury" may have been inaccurate.

24 Feb 2017

NR could potentially prevent chemotherapy-induced peripheral neuropathy in cancer patients

A new study in rats suggests that nicotinamide riboside (NR), a form of vitamin B3, may be useful for treating or preventing nerve pain (neuropathy) caused by chemotherapy drugs.

24 Feb 2017

Treating multiple myeloma with rabbit virus eliminates majority of malignant cells, study shows

Treating multiple myeloma (MM) with myxoma virus (MYXV) eliminated a majority of malignant cells in preclinical studies, report investigators at the Medical University of South Carolina and elsewhere in an article published online on December 7, 2016 by Molecular Therapy -- Oncolytics.

22 Feb 2017

Melanoma patients' immunotherapy response linked to diversity and makeup of gut bacteria

Melanoma patients' response to a major form of immunotherapy is associated with the diversity and makeup of trillions of potential allies and enemies found in the digestive tract, researchers at The University of Texas MD Anderson Cancer Center report at the ASCO-Society for Immunotherapy in Cancer meeting in Orlando.

22 Feb 2017

Researchers identify genetic cause of novel myoclonic epilepsy in dogs

Researh groups from the University of Helsinki, the LMU Munich and the University of Guelph have described in collaboration a novel myoclonic epilepsy in dogs and identified its genetic cause.

21 Feb 2017

Researchers aim to recreate ‘tick cement’ as potential bioadhesive for human tissues

Ticks are well known for their ability to anchor themselves firmly to the skin, so that they can suck blood for several days.

20 Feb 2017

Targeting biological clock in cancer cells could inhibit tumour growth

Does the biological clock in cancer cells influence tumour growth? Yes, according to a study conducted by Nicolas Cermakian, a professor in McGill University's Department of Psychiatry.

16 Feb 2017

Clinical trial to test potential new drug treatment for osteoarthritis

The University of Liverpool, in partnership with AKL Research and Development Ltd, is to lead on a clinical trial to test a potential new drug treatment for osteoarthritis.

16 Feb 2017

Review shows lipid nanoparticles as highly promising delivery systems in gene therapy

Lipid nanoparticles (SLNs and NLCs) are regarded as highly promising systems for delivering nucleic acids in gene therapy.

14 Feb 2017

Scientists identify new biomarkers that could guide bowel cancer treatment

Colorectal carcinomas arise in different forms, so all treatments do not work for all patients. OncoTrack, a public-private consortium supported by the Innovative Medicines Initiative Joint Undertaking, has conducted one of Europe's largest collaborative academic-industry research projects to develop and assess novel approaches for identification of new markers for colon cancer.

13 Feb 2017

Scientists identify vulnerabilities of highly aggressive pancreatic cancer cells

Researchers have identified a gatekeeper protein that prevents pancreatic cancer cells from transitioning into a particularly aggressive cell type and also found therapies capable of thwarting those cells when the gatekeeper is depleted.

9 Feb 2017

Researchers develop microfluidic device to study interactions between drugs and cells in kidneys

Instead of running tests on live kidneys, researchers at Binghamton, University State University of New York have developed a model kidney for working out the kinks in medicines and treatments.

9 Feb 2017

New therapeutic agent shows potential for treating optic neuritis linked to multiple sclerosis

A new therapeutic agent tested in a mouse model of multiple sclerosis (MS) produced anti-inflammatory activity and prevented loss of cells in the optic nerve, according to a new study by researchers in the Perelman School of Medicine at the University of Pennsylvania, with Pittsburgh-based Noveome Biotherapeutics.

9 Feb 2017

Genetic variant encoded in NCF1 linked to increased risk for autoimmune diseases, study shows

Investigators at the Medical University of South Carolina report pre-clinical research showing that a genetic variant encoded in neutrophil cystolic factor 1 (NCF1) is associated with increased risk for autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis, and Sjögren's syndrome, in the January 2017 issue of Nature Genetics.

8 Feb 2017

New ‘release and kill’ strategy may shorten treatment periods for patients with tuberculosis

Mycobacterium tuberculosis has been called "the perfect pathogen." These bacteria hijack human macrophages, persist inside the cells to evade immune destruction, and then prevent the macrophage from undergoing programmed cell death.

8 Feb 2017

Study highlights need for increased vigilance when using GFAP, UCH-L-1 as potential biomarkers of mTBI

In patients who suffered acute orthopedic injuries, two proposed biomarkers for mild traumatic brain injury (mTBI) were not able to distinguish between patients who did or did not have mTBI.

7 Feb 2017

New Zika vaccine candidate shows potential to protect against virus with single dose

A new Zika vaccine candidate has the potential to protect against the virus with a single dose, according to a research team led by scientists from the Perelman School of Medicine at the University of Pennsylvania.

2 Feb 2017

Increased growth factor protects retinal blood vessels in animal models with diabetes

Researchers from the Schepens Eye Research Institute of Massachusetts Eye and Ear have shown that a slight increase in transforming growth factor beta (TGF-β), which is present in preclinical animal models with diabetic eye disease, protects retinal blood vessels from damage that commonly occurs in the early stages of the disease.

2 Feb 2017

Deep brain stimulation can reduce heroin relapse in rat models of addiction, TSRI study shows

Scientists at The Scripps Research Institute have found that deep brain stimulation (DBS) can greatly reduce the compulsion to use heroin in standard rat models of addiction.

2 Feb 2017

European researchers highlight potential of xenografts in cancer research and treatment

European research lays the foundation for the development of new and ambitious research projects with xenografts derived from patients, preclinical models with great potential to advance research and treatment in cancer.

1 Feb 2017

Preclinical News and Research

Initial diagnosis of acute kidney injury may be inaccurate for many patients, study suggests

NR could potentially prevent chemotherapy-induced peripheral neuropathy in cancer patients

Treating multiple myeloma with rabbit virus eliminates majority of malignant cells, study shows

Melanoma patients' immunotherapy response linked to diversity and makeup of gut bacteria

Researchers identify genetic cause of novel myoclonic epilepsy in dogs

Researchers aim to recreate ‘tick cement’ as potential bioadhesive for human tissues

Targeting biological clock in cancer cells could inhibit tumour growth

Clinical trial to test potential new drug treatment for osteoarthritis

Review shows lipid nanoparticles as highly promising delivery systems in gene therapy

Scientists identify new biomarkers that could guide bowel cancer treatment

Scientists identify vulnerabilities of highly aggressive pancreatic cancer cells

Researchers develop microfluidic device to study interactions between drugs and cells in kidneys

New therapeutic agent shows potential for treating optic neuritis linked to multiple sclerosis

Genetic variant encoded in NCF1 linked to increased risk for autoimmune diseases, study shows

New ‘release and kill’ strategy may shorten treatment periods for patients with tuberculosis

Study highlights need for increased vigilance when using GFAP, UCH-L-1 as potential biomarkers of mTBI

New Zika vaccine candidate shows potential to protect against virus with single dose

Increased growth factor protects retinal blood vessels in animal models with diabetes

Deep brain stimulation can reduce heroin relapse in rat models of addiction, TSRI study shows

European researchers highlight potential of xenografts in cancer research and treatment

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