Preclinical News and Research

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Genes implicated in rare pediatric epilepsy contribute to common forms of disorder, study finds

An international study led by Columbia University Medical Center and NewYork-Presbyterian researchers has found that several genes previously implicated only in rare, severe forms of pediatric epilepsy also contribute to common forms of the disorder.

12 Jan 2017

NCI launches new drug formulary to help expedite use of agents in clinical studies

The National Cancer Institute today launched a new drug formulary (the "NCI Formulary") that will enable investigators at NCI-designated Cancer Centers to have quicker access to approved and investigational agents for use in preclinical studies and cancer clinical trials.

11 Jan 2017

Transfusion of ‘oldest blood’ may lead to complications in some patients

The oldest blood available for transfusions releases large and potentially harmful amounts of iron into patients' bloodstreams, a new study by researchers at Columbia University Medical Center has found.

10 Jan 2017

NIH highlights key tips and facts about glaucoma

January is Glaucoma Awareness Month. The National Eye Institute, part of NIH, is highlighting key facts about this blinding disease, important tips for prevention and treatment, and research updates you may not know about.

10 Jan 2017

New research suggests novel combination approach to fight against gliomas

"Devastating" and "dismal." That's how leading researchers describe the present outlook for malignant brain tumors. The median survival rate for patients with glioblastoma multiforme, or GBM, is a mere 14.2 months.

4 Jan 2017

Researchers develop first non-human primate X-SCID models using genome editing techniques

Researchers affiliated with the Kawasaki INnovation Gateway at SKYFRONT, have successfully generated the first ever non-human primate X-SCID models by using two genome editing techniques. The findings were published in Cell Stem Cell, July 2016.

3 Jan 2017

AAV-based gene therapy to treat liver disorders advances into human testing

Liver-directed gene therapy delivered using adeno-associated viral (AAV) vectors to treat diseases such as hemophilia have advanced into human testing.

30 Dec 2016

Two research studies on new molecules could potentially treat Alzheimer's disease

This year, results have been published of two significant research studies about molecules that could potentially treat Alzheimer's disease.

30 Dec 2016

Fred Hutch’s new Evergreen Fund to promote commercialization of research into lifesaving therapies

Fred Hutchinson Cancer Research Center announced its first-ever grants from its newly established Evergreen Fund to spur researchers' efforts to advance bold ideas toward creating or partnering with a commercial entity.

28 Dec 2016

New computational tool can predict personal cancer driver genes to optimize treatment

Columbia University Medical Center researchers have created a computational tool that can rapidly predict which genes are implicated in an individual's cancer and recommend treatments.

22 Dec 2016

AXT makes magnetic particle imaging technology available to researchers in Australia

AXT is proud to be able to bring another cutting-edge technology to Australia that will help our medical researchers accelerate the rate at which they bring new cures, remedies and therapies to clinical realities.

From AXT Pty Ltd 21 Dec 2016

Researchers receive NIH grant to map molecular changes linked to physical movement

A research team led by Robert Gerszten, MD, Chief of Cardiovascular Medicine at Beth Israel Deaconess Medical Center and a Senior Associate Member of the Broad Institute, has received an award of more than $11 million as part of the Molecular Transducers of Physical Activity in Humans consortium, a large-scale initiative of the National Institutes of Health to investigate and map the molecular changes that occur in our bodies during and after exercise.

17 Dec 2016

Overexpression of nerve growth factor drives gastric tumorigenesis in mice

Gastric tumors are started by specialized cells in the stomach that signal nerves to make more acetylcholine, according to a study in mice.

16 Dec 2016

Researchers identify attractive drug candidate to target glioma tumors

In a paper published today in Cancer Research, researchers: 1) identify a biomarker enzyme associated with aggressive glioma brain tumors, 2) reveal the regulatory mechanism for that enzyme, and 3) demonstrate potent efficacy, using a mouse model of glioma, for a small molecule inhibitor they have developed.

16 Dec 2016

Small, simple-to-use microfluidic device could speed up adoption of new anti-cancer treatments

RESEARCHERS at the University of Huddersfield have helped develop a lab device that could speed up the adoption of new anti-cancer treatments.

16 Dec 2016

Over-the-counter antioxidant may promote reductions in alcohol use in marijuana-dependent teens

An over-the-counter antioxidant known as N-acetylcysteine (NAC) is showing early promise at promoting abstinence from or reduced use of alcohol in marijuana-dependent adolescents, report researchers at the Medical University of South Carolina (MUSC) in the December 2016 Addictive Behaviors.

15 Dec 2016

Controversial hormone could fight against recurring breast cancers

An international team of researchers involving the University of Adelaide is tackling the controversy over what some scientists consider to be a "harmful" hormone, arguing that it could be a game changer in the fight against recurring breast cancers that are resistant to standard treatments.

9 Dec 2016

Researchers show how common bacterium in improperly cooked chicken triggers GBS

A Michigan State University research team is the first to show how a common bacterium found in improperly cooked chicken causes Guillain-Barre Syndrome, or GBS.

9 Dec 2016

ABIVAX reports preclinical data on first-in-class drug candidate for functional cure of HIV/AIDS patients

ABIVAX an innovative biotechnology company targeting the immune system to eliminate viral disease, announced today that the Company presented new preclinical data on ABX464, ABIVAX's first-in-class drug candidate for a functional cure of patients with HIV/AIDS, during this week's HIV DART scientific conference in Los Cabos, Mexico.

9 Dec 2016

New model can simplify process of mixing perfect drug cocktails

Drug cocktails, such as those for treating cancer, are best when the proper ingredients are mixed in the right proportions - just like the alcoholic versions offered at the local bar.

9 Dec 2016

Preclinical News and Research

Genes implicated in rare pediatric epilepsy contribute to common forms of disorder, study finds

NCI launches new drug formulary to help expedite use of agents in clinical studies

Transfusion of ‘oldest blood’ may lead to complications in some patients

NIH highlights key tips and facts about glaucoma

New research suggests novel combination approach to fight against gliomas

Researchers develop first non-human primate X-SCID models using genome editing techniques

AAV-based gene therapy to treat liver disorders advances into human testing

Two research studies on new molecules could potentially treat Alzheimer's disease

Fred Hutch’s new Evergreen Fund to promote commercialization of research into lifesaving therapies

New computational tool can predict personal cancer driver genes to optimize treatment

AXT makes magnetic particle imaging technology available to researchers in Australia

Researchers receive NIH grant to map molecular changes linked to physical movement

Overexpression of nerve growth factor drives gastric tumorigenesis in mice

Researchers identify attractive drug candidate to target glioma tumors

Small, simple-to-use microfluidic device could speed up adoption of new anti-cancer treatments

Over-the-counter antioxidant may promote reductions in alcohol use in marijuana-dependent teens

Controversial hormone could fight against recurring breast cancers

Researchers show how common bacterium in improperly cooked chicken triggers GBS

ABIVAX reports preclinical data on first-in-class drug candidate for functional cure of HIV/AIDS patients

New model can simplify process of mixing perfect drug cocktails

Event guide: 4th LNP Formulation & Process Development Summit eBook

Latest eBooks

Editorial Focus eBook - Spatial and single-cell omics (1st edition)

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics