Preclinical News and Research

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Investigational diabetes drug that impedes Parkinson's progression getting ready for human trials

A new investigational drug originally developed for type 2 diabetes is being readied for human clinical trials in search of the world's first treatment to impede the progression of Parkinson's disease following publication of research findings today in the journal Science Translational Medicine.

7 Dec 2016

MUSC researchers harness cutting-edge technology to uncover new role for pericytes during stroke

Pericytes are the primary locus of matrix-mellaproteinase-9-dependent (MMP-9) capillary damage and blood leakage during ischemia, according to preclinical findings reported by Medical University of South Carolina investigators in an article published online on November 14, 2016 by The Journal of Neuroscience.

5 Dec 2016

Hemophilia B patients produce near-normal levels of clotting factor IX after gene therapy, study shows

Researchers are reporting the highest and most sustained levels to date of the essential blood-clotting factor IX in patients with the inherited bleeding disorder hemophilia B.

4 Dec 2016

Auditory deficits in people with schizophrenia linked to dysfunctional brain receptors

The inability to hear subtle changes in pitch, a common and debilitating problem for people with schizophrenia, is due to dysfunctional N-methyl-D-aspartate (NMDA) brain receptors, according to a study by Columbia University Medical Center researchers.

2 Dec 2016

$Experts explore if DXA-derived measurements could predict fracture risk in diabetic patients$

Experts explore if DXA-derived measurements could predict fracture risk in diabetic patients

Increased risk of fracture has been shown to be one of the complications arising from longstanding diabetes. With the worldwide increase in Type 2 Diabetes (T2D), in part due to aging populations, there is also increasing concern about how to identify and manage patients with diabetes who are at high risk of osteoporotic fracture.

1 Dec 2016

Bone density could be one of early indicators of brain degeneration in Alzheimer's disease

Researchers at NEOMED have just identified a major connection between areas of the brainstem - the ancient area that controls mood, sleep and metabolism - and detrimental changes to bone in a preclinical model of Alzheimer's disease (AD).

1 Dec 2016

New mouse model provides key information for understanding cortical circuit development

A day by day log of cortical electric activity in the mouse visual cortex was published in the Journal of Neuroscience by George Washington University researcher Matthew Colonnese, Ph.D.

1 Dec 2016

Penn researchers use CRISPR/Cas9 gene targeting approach to treat hemophilia B in mice

CRISPR/Cas9, a powerful genome editing tool, is showing promise for efficient correction of disease-causing mutations.

1 Dec 2016

Enzyme research provides new insights into pathophysiology of depression

Despite the fact that more than four percent of the world's population suffer from depression, and even though approximately 1,500 individuals commit suicide each year in Sweden, the understanding of the pathophysiology of depression remains unclear and only a few new discoveries of mechanisms behind it have been made in recent years.

29 Nov 2016

New self-regulating smart patch releases blood-thinning drugs when necessary

An interdisciplinary team of researchers has developed a smart patch designed to monitor a patient's blood and release blood-thinning drugs as needed to prevent the occurrence of dangerous blood clots - a condition known as thrombosis.

29 Nov 2016

Inflammatory marker detected in blood tests can better predict risk of death, study suggests

A new study looking at deaths from cancer, cardiovascular disease and all causes suggests that an inflammatory marker detected in blood tests in middle-aged adults can better predict the risk of death compared with another similar biomarker.

29 Nov 2016

Karolinska Institute biologist receives 2016 Naomi Berrie Award for excellence in diabetes research

Columbia University has awarded the 2016 Naomi Berrie Award for Outstanding Achievement in Diabetes Research to Peter Arner, MD, PhD, a Distinguished Professor in the Department of Medicine at the Karolinska Institute, whose studies on the turnover of fat tissue in the human body has revealed processes that contribute to obesity and diabetes.

23 Nov 2016

Clinically-proven pharmacy product effective against causes of Traveller's Diarrhoea

It is not only overseas holidays that can be ruined by the dreaded Traveller's Diarrhoea.

23 Nov 2016

New review highlights challenges of studying resistance to antiangiogenic treatment in preclinical models

New blood vessel growth, or angiogenesis, is critical for cancer to grow and spread throughout the body.

21 Nov 2016

Scientists develop genetically engineered T cells with fusion inhibitor to disrupt HIV's harpoon

When HIV attacks a T cell, it attaches itself to the cell's surface and launches a "harpoon" to create an opening to enter and infect the cells.

18 Nov 2016

Children born to mothers with rheumatoid arthritis may have increased risk of developing epilepsy

A new study shows a link between mothers with rheumatoid arthritis and children with epilepsy.

16 Nov 2016

New hydrogel-based vascular embolization may offer great advantage for treating clotting disorders

Small blood clots called emboli are mostly known for traveling through the vasculature before they lodge and obstruct vessels, impeding blood and oxygen supply to organs like the lung.

16 Nov 2016

Enterome, Bristol-Myers Squibb enter into Immuno-Oncology collaboration to identify new microbiome-derived biomarkers for cancer

Bristol-Myers Squibb (NYSE: BMY) and Enterome SA (Enterome), a pioneer in the development of pharmaceuticals and diagnostics based on the gut microbiome, announced that they have entered into an Immuno-Oncology focused collaboration agreement for the discovery and development of microbiome-derived biomarkers, drug targets and bioactive molecules to be developed as potential companion diagnostics and therapeutics for cancer.

16 Nov 2016

Promethera presents new preclinical NASH-Fibrosis data from HepaStem program at AASLD meeting

Promethera Biosciences SA, a world-leading cell therapy and regenerative medicine company targeting liver diseases, today announced the presentation of new preclinical NASH-Fibrosis data from its proprietary HepaStem program, demonstrating a beneficial effect of HepaStem in a nonalcoholic steatohepatitis (NASH) mouse model and confirming Hepastem’s unique and multifaceted mode of action.

15 Nov 2016

Retinitis pigmentosa can be slowed by reprogramming metabolism of photoreceptors, study shows

Columbia University Medical Center researchers have demonstrated that vision loss associated with a form of retinitis pigmentosa (RP) can be slowed dramatically by reprogramming the metabolism of photoreceptors, or light sensors, in the retina.

15 Nov 2016

Preclinical News and Research

Investigational diabetes drug that impedes Parkinson's progression getting ready for human trials

MUSC researchers harness cutting-edge technology to uncover new role for pericytes during stroke

Hemophilia B patients produce near-normal levels of clotting factor IX after gene therapy, study shows

Auditory deficits in people with schizophrenia linked to dysfunctional brain receptors

Experts explore if DXA-derived measurements could predict fracture risk in diabetic patients

Bone density could be one of early indicators of brain degeneration in Alzheimer's disease

New mouse model provides key information for understanding cortical circuit development

Penn researchers use CRISPR/Cas9 gene targeting approach to treat hemophilia B in mice

Enzyme research provides new insights into pathophysiology of depression

New self-regulating smart patch releases blood-thinning drugs when necessary

Inflammatory marker detected in blood tests can better predict risk of death, study suggests

Karolinska Institute biologist receives 2016 Naomi Berrie Award for excellence in diabetes research

Clinically-proven pharmacy product effective against causes of Traveller's Diarrhoea

New review highlights challenges of studying resistance to antiangiogenic treatment in preclinical models

Scientists develop genetically engineered T cells with fusion inhibitor to disrupt HIV's harpoon

Children born to mothers with rheumatoid arthritis may have increased risk of developing epilepsy

New hydrogel-based vascular embolization may offer great advantage for treating clotting disorders

Enterome, Bristol-Myers Squibb enter into Immuno-Oncology collaboration to identify new microbiome-derived biomarkers for cancer

Promethera presents new preclinical NASH-Fibrosis data from HepaStem program at AASLD meeting

Retinitis pigmentosa can be slowed by reprogramming metabolism of photoreceptors, study shows

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