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Three-dose regimen of HEPLISAV-B vaccine fully protects people living with HIV, data shows

The AIDS Clinical Trials Group (ACTG), the world's largest HIV research network whose focus has expanded to include evaluating outpatient treatment for COVID-19, today presented a session demonstrating that a three-dose regimen of the HEPLISAV-B vaccine fully protected people living with HIV at IDWeek 2022, taking place in Washington D.C. from October 19-22, 2022.

20 Oct 2022

Exploring molecular docking and molecular dynamics simulations as advanced tools for novel antiviral drug discovery

Researchers presented an overview of factors influencing emerging infectious diseases. They also highlighted the importance of molecular dynamic (MD) simulations and molecular docking (MDO) analysis for combating these diseases.

17 Oct 2022

Could COVID-19 infections trigger a relapse of mycosis fungoides or other cutaneous T-cell lymphomas?

Recently, authors highlighted the potential role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in triggering the relapse of mycosis fungoides, a type of cutaneous T-cell lymphoma.

17 Oct 2022

HIV patients with moderate immune suppression at greater risk of severe COVID-19 "breakthrough" infection

People with HIV who have moderate immune suppression appear to be at greater risk of severe COVID-19 "breakthrough" infection after vaccination, according to a study led by researchers at the Johns Hopkins Bloomberg School of Public Health.

13 Oct 2022

What is the association between interferon genes and complement regulatory protein expressions in SARS-CoV-2 infections?

Researchers investigated the expression of complement regulatory proteins (CRPs) in coronavirus disease 2019 (COVID-19) to identify potential dysregulated CRP patterns and investigate whether they contribute to COVID-19 pathogenesis.

13 Oct 2022

Antibody response trajectories among solid organ transplant recipients in association with mycophenolate mofetil administration

Researchers explored the trajectory of antibody (Ab) titers after coronavirus disease 2019 (COVID-19) vaccination among solid organ transplant recipients (SOTs) with or without mycophenolate mofetil (MMF), or withdrawn from MMF.

11 Oct 2022

Metformin reduces risk of severe COVID-19 in diabetic patients

A new study determines whether antidiabetic agents can reduce complications in COVID-19 patients with diabetes.

10 Oct 2022

Exploring the biomarker profiles in severe COVID-19

In new research, researchers estimated the D-dimer levels and characterized lymphocyte subsets and cytokine profiles in severe coronavirus disease 2019 (COVID-19) patients.

7 Oct 2022

Study suggests an immunological benefit of combining previous natural infection with vaccination against COVID-19 using a combination of different vaccine platforms

Researchers explored SARS-CoV-2-targeted immune responses among COVAC1 participants who received a novel saRNA vaccine followed by the mRNA BNT162b2 vaccine BNT162b2 vaccine, with or without prior COVID-19 history.

7 Oct 2022

Study links pancreatic cancer survival outcomes with arrangement of immune cells in tumors

Researchers from Johns Hopkins Medicine have discovered that the organization of different types of immune cells within pancreatic tumors is associated with how well patients with pancreatic cancer respond to treatment and how long they survive.

6 Oct 2022

Did telehealth appointments improve HIV care retention during the COVID-19 pandemic?

In a new study, researchers assessed how measures of retention in human immunodeficiency virus (HIV) care have changed due to the COVID-19 pandemic.

6 Oct 2022

Epigenetics drug used to treat blood cancers, rare sarcomas can halt bladder cancer growth

An epigenetics drug currently being used for the treatment of blood cancers and rare sarcomas can stop the growth of bladder cancer by activating the immune system, reports a new Northwestern Medicine study done in mice.

5 Oct 2022

Novel protein vaccine NVX-CoV2373 triggered functional T cell responses to SARS-CoV-2

Researchers determined the T cell response to the NVX-CoV2373, an adjuvanted recombinant full-length SARS-CoV-2 spike (S) trimer protein vaccine.

5 Oct 2022

Omicron reduces host antibody response by lower B-cell antigenicity

A new study explores the functional relevance of some Omicron mutations in terms of their ability to escape neutralizing antibody responses.

4 Oct 2022

How COVID-19 affects the female reproductive system

A new review in the Biology of Reproduction journal analyzed the relationship between the immune system and the female reproductive system while focusing on the effects of COVID-19-associated immune responses on the reproductive system. The study searched PubMed to identify peer-reviewed literature in English up to May 2022 and finally included 83 studies.

3 Oct 2022

A case for updating COVID vaccines with beta variant spike sequences

A recent Nature Communications study has discussed preclinical and clinical data on COVID-19 vaccine antigens that could be utilized to develop effective booster vaccines.

3 Oct 2022

Novel linear DNA SARS-CoV-2 vaccine using electroporation-aided vaccine delivery reveals lower viral shedding in ferrets

Researchers evaluated the efficacy, immunogenicity, and safety of a novel SARS-CoV-2 linear deoxyribonucleic acid vaccine in ferret models delivered using intramuscular injection and electroporation.

3 Oct 2022

Shape-shifting mitochondria influence Th17 cells’ propensity for autoimmune activity

A new study focused on the immune system's Th17 cells suggests that the shape and function of their mitochondria (the powerhouse of cells) is important in autoimmune and inflammatory disorders, such as multiple sclerosis.

28 Sep 2022

Dietary fiber guar gum limits inflammation and delays the onset of MS symptoms in mice

Diets high in guar gum, a common food additive and dietary fiber, limited inflammation and delayed the onset of multiple sclerosis (MS) symptoms in mice, according to new research by members of the University of British Columbia Microbiology and Immunology department.

27 Sep 2022

Transplantation tolerance associated with conventional T cells’ susceptibility to Treg suppression

Patients who receive organ transplants must take powerful medications to prevent the immune system from rejecting the organ.

27 Sep 2022

CD4 News and Research

Three-dose regimen of HEPLISAV-B vaccine fully protects people living with HIV, data shows

Exploring molecular docking and molecular dynamics simulations as advanced tools for novel antiviral drug discovery

Could COVID-19 infections trigger a relapse of mycosis fungoides or other cutaneous T-cell lymphomas?

HIV patients with moderate immune suppression at greater risk of severe COVID-19 "breakthrough" infection

What is the association between interferon genes and complement regulatory protein expressions in SARS-CoV-2 infections?

Antibody response trajectories among solid organ transplant recipients in association with mycophenolate mofetil administration

Metformin reduces risk of severe COVID-19 in diabetic patients

Exploring the biomarker profiles in severe COVID-19

Study suggests an immunological benefit of combining previous natural infection with vaccination against COVID-19 using a combination of different vaccine platforms

Study links pancreatic cancer survival outcomes with arrangement of immune cells in tumors

Did telehealth appointments improve HIV care retention during the COVID-19 pandemic?

Epigenetics drug used to treat blood cancers, rare sarcomas can halt bladder cancer growth

Novel protein vaccine NVX-CoV2373 triggered functional T cell responses to SARS-CoV-2

Omicron reduces host antibody response by lower B-cell antigenicity

How COVID-19 affects the female reproductive system

A case for updating COVID vaccines with beta variant spike sequences

Novel linear DNA SARS-CoV-2 vaccine using electroporation-aided vaccine delivery reveals lower viral shedding in ferrets

Shape-shifting mitochondria influence Th17 cells’ propensity for autoimmune activity

Dietary fiber guar gum limits inflammation and delays the onset of MS symptoms in mice

Transplantation tolerance associated with conventional T cells’ susceptibility to Treg suppression

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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