DNA Damage News and Research

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The loss of epigenetic information accelerates the aging process

A new study in the journal Cell aimed to determine whether epigenetic changes are a cause of mammalian aging.

15 Jan 2023

Comprehensive atlas of protein kinases could help scientists decipher many cellular signaling pathways

One of the most important classes of human enzymes are protein kinases - signaling molecules that regulate nearly all cellular activities, including growth, cell division, and metabolism.

12 Jan 2023

Researchers discover the Nrf3-mediated mechanism of melanogenesis

The skin is presumably the largest and one of the most versatile body organs. By providing a physical barrier, it protects our body from environmental assaults.

11 Jan 2023

Anticancer drugs offer new hope for treatment of sepsis

Research led by the IGC reveals how these drugs limit inflammation, positioning them as potential treatments for sepsis.

10 Jan 2023

Sarunashi juice and its constituting component help prevent and reduce lung cancer in mice

Lung cancer is the leading cause of death in Japan and across the globe. Among all the cancers, lung cancer has one of the lowest five-year survival rates.

28 Dec 2022

Radiation damage to mature sperm cannot be repaired and is instead passed on to the offspring

Whether radiation exposure of fathers can have consequences on their children is one of the most long-standing questions in radiation biology.

21 Dec 2022

New method combines injectable radioactive gel with systemic chemotherapy to treat pancreatic cancer

Pancreatic cancer is one of the deadliest types of cancer - in the U.S., it is estimated that over 88 percent of people will die from the disease within five years of their diagnosis.

20 Dec 2022

New combination of drugs may lead to improved treatment of cervical cancer

A new combination of drugs slowed the growth of cancer cells by an unexpected mechanism that may one day lead to improved treatment of cervical cancer, a UT Southwestern-led study published in Molecular Cancer Research suggests.

19 Dec 2022

Inhibiting inflammatory signaling pathway could reduce the chances of heart disease in cancer survivors

Researchers at Memorial Sloan Kettering Cancer Center (MSKCC) in New York have discovered that common cancer treatments, such as radiotherapy or anthracycline drugs, cause long-term damage to heart tissue by activating a key inflammatory signaling pathway.

19 Dec 2022

Severe COVID-19 causes aging-like changes in the human brain

Severe COVID-19 triggers aging-like changes in the brain's frontal cortex region that results in cognitive deficits.

11 Dec 2022

Better understanding of DNA repair mechanism may pave the way for effective cancer treatments

Better understanding of the mechanisms involved in DNA repair may pave the way for developing inhibitors to improve the effectiveness of radiation therapy.

9 Dec 2022

Study reports overall response of HER2-low breast cancer patients to neoadjuvant T-DXd treatment

Patients with localized, hormone receptor-positive, HER2-low breast cancer treated with trastuzumab deruxtecan (T-DXd, Enhertu) in the neoadjuvant setting had an overall response rate of 75 percent in the absence of anastrozole and 63 percent in combination with anastrozole, according to results from the phase II TRIO-US B-12 TALENT trial presented at the San Antonio Breast Cancer Symposium, held December 6-10, 2022.

7 Dec 2022

CRC 1361 at JGU continues to achieve excellence in DNA repair and genome stability research

The German Research Foundation (DFG) announced the prolongation of the Collaborative Research Center (CRC) 1361: "Regulation of DNA Repair and Genome Stability" for an additional four years.

2 Dec 2022

The potential of grape consumption to modulate UV-induced skin erythema

A recent Antioxidants study evaluated the effect of grape consumption on reducing UV-induced skin erythema.

2 Dec 2022

Collaborative work unravels hidden molecular secrets of age-related diseases

Insilico Medicine, a clinical-stage end-to-end artificial intelligence (AI)-driven drug discovery company, and the University of Copenhagen announced today the release of the first batch of results from the collaborative work directed to perform multi-omics-based analyses in the context of age-related diseases using an AI-driven target and drug discovery pipeline.

2 Dec 2022

Scientists discover how an enzyme involved in DNA repair becomes vital to tumor survival

Scientists at the Francis Crick Institute, in collaboration with Artios, have identified how an enzyme involved in DNA repair (POLQ), becomes vital to the survival of certain cancers, if the cancer cells lose the ability to use a more common method of DNA repair.

30 Nov 2022

DNA Damage News and Research

The loss of epigenetic information accelerates the aging process

Comprehensive atlas of protein kinases could help scientists decipher many cellular signaling pathways

Researchers discover the Nrf3-mediated mechanism of melanogenesis

Anticancer drugs offer new hope for treatment of sepsis

Sarunashi juice and its constituting component help prevent and reduce lung cancer in mice

Radiation damage to mature sperm cannot be repaired and is instead passed on to the offspring

New method combines injectable radioactive gel with systemic chemotherapy to treat pancreatic cancer

New combination of drugs may lead to improved treatment of cervical cancer

Inhibiting inflammatory signaling pathway could reduce the chances of heart disease in cancer survivors

Severe COVID-19 causes aging-like changes in the human brain

Better understanding of DNA repair mechanism may pave the way for effective cancer treatments

Study reports overall response of HER2-low breast cancer patients to neoadjuvant T-DXd treatment

CRC 1361 at JGU continues to achieve excellence in DNA repair and genome stability research

The potential of grape consumption to modulate UV-induced skin erythema

Collaborative work unravels hidden molecular secrets of age-related diseases

Scientists discover how an enzyme involved in DNA repair becomes vital to tumor survival

Study identifies risk factors that increase Black men's susceptibility to early-onset prostate cancer

Researchers highlight the importance of localizing BRCA gene mutations for better ovarian cancer treatment

Two studies emphasize the need for ethnically diverse prostate cancer genetic testing

Study reveals structural insights into the elusive tankyrase protein that fuels bowel cancer

Understanding the DNA Damage Response in Innate Immunity eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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