Metastasis News and Research

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Metastasis is the spread of cancer from one part of the body to another. A tumor formed by cells that have spread is called a “metastatic tumor” or a “metastasis.” The metastatic tumor contains cells that are like those in the original (primary) tumor. The plural form of metastasis is metastases

16 promising postdoctoral scientists awarded Damon Runyon Fellowships for cancer research

The Damon Runyon Cancer Research Foundation has named 16 new Damon Runyon Fellows, exceptional postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators.

28 Aug 2024

Targeting cancer cells by cutting off essential nutrients and backup supplies

Cancer cells have voracious appetites. And there are certain nutrients they can't live without. Scientists have long hoped they might stop tumors in their tracks by cutting off an essential part of cancer cells' diet.

28 Aug 2024

Olaparib effective against BRCA2-mutated prostate cancer

The anti-cancer drug olaparib may be effective in treating biochemically recurrent prostate cancer without accompanying hormone therapy for men who have mutations in genes such as BRCA2, according to results of a phase II clinical trial of 51 patients conducted at the Johns Hopkins Kimmel Cancer Center and three other sites.

23 Aug 2024

Fasting and ketogenic diet reveal new vulnerability of pancreatic tumors to existing cancer drug

Researchers examine the role of fasting and ketogenesis in regulating protein synthesis and its potential implications for cancer therapy.

21 Aug 2024

Researchers reveal impact of genetic ancestry on breast cancer risk and cell diversity

Researchers map the diverse cell types present in healthy breast tissue to elucidate the role of genetic ancestry in breast cancer risk.

20 Aug 2024

Simplifying cell movement analysis with CellTracksColab

Studying cell migration is vital because it plays a crucial role in many biological processes, including immune response, wound healing, and cancer metastasis.

16 Aug 2024

New nanobody shows potential in preventing lung metastasis of breast tumor cells

A new research paper was published in Oncotarget's Volume 15 on August 14, 2024, entitled, "A nanobody against the V-ATPase c subunit inhibits metastasis of 4T1-12B breast tumor cells to lung in mice."

16 Aug 2024

New research gives unprecedented view of colorectal cancer genetic makeup

Researchers provided a comprehensive genomic characterization of colorectal carcinoma, a type of cancer that starts in the colon or rectum, through whole-genome sequencing of 2,023 samples, identifying novel driver genes, molecular subgroups, and potential clinical implications.

15 Aug 2024

Largest multi-omics study identifies new genetic landscapes in colorectal cancer

The Institute of Intelligent Medical Research (IIMR) of BGI Genomics, in collaboration with Sweden's Uppsala University, has published the largest multi-omics study of colorectal cancer (CRC) to date.

13 Aug 2024

Personalized treatment strategies based on calcification status in breast cancer

Mammographic calcifications, a common feature of breast cancer, have remained enigmatic in terms of their molecular underpinnings and clinical implications, particularly in the hormone receptor-positive, HER2-negative subtype.

13 Aug 2024

Review explores potential for improved use of anti-angiogenic agents in cancer therapy

Most tumors release various signaling molecules to support their incessant growth, invasion, and metastasis.

9 Aug 2024

Insilico Medicine's pan-TEAD inhibitor ISM6331 receives FDA IND clearance for mesothelioma treatment

Insilico Medicine ("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven biotechnology company, today announced ISM6331, potential best-in-class pan-TEAD inhibitor, has received the U.S. Food and Drug Administration (FDA) Investigational New Drug (IND) clearance for the treatment of mesothelioma, following the grant of Orphan Drug Designation (ODD) in June 2024. It brings the total number of IND-approved molecules of Insilico to nine.

8 Aug 2024

Drug shows new promise in treating breast cancer with brain metastases or recurrent glioblastoma

A drug effective in treating breast cancer shows new promise in addressing breast cancer with brain metastases or recurrent glioblastoma, as reported by results of a prospective window-of-opportunity trial at the University of Texas Health Science Center at San Antonio (UT Health San Antonio).

8 Aug 2024

New insights into the role of cancer-associated fibroblasts in promoting lymphatic metastasis

Lymph node metastasis is a crucial factor in cancer progression, significantly affecting patient prognosis and treatment outcomes.

8 Aug 2024

Sensory nerves drive breast cancer growth and spread, study reveals

Cancer doesn't grow in a vacuum - each tumor grows in a particular microenvironment within the body and spreads through a tangled web of vasculature and nerves.

7 Aug 2024

The interplay of liver cancer stem cells and immune cells in tumor microenvironment

The complex dynamics between liver cancer stem cells (CSCs) and immune cells within the tumor microenvironment (TME) are central to the progression of liver cancer. These interactions are critical in creating an immunosuppressive setting that significantly impacts the response to immunotherapy. Liver CSCs, responsible for tumor initiation, metastasis, therapeutic resistance, and recurrence, exhibit heterogeneity and are characterized by various surface markers that contribute to their stemness and metastatic potential.

7 Aug 2024

INT-1B3 enhances anti-tumor immunity and prolongs survival in mouse models

A new research paper was published in Oncotarget's Volume 15 on July 12, 2024, entitled, "INT-1B3, an LNP formulated miR-193a-3p mimic, promotes anti-tumor immunity by enhancing T cell mediated immune responses via modulation of the tumor microenvironment and induction of immunogenic cell death."

5 Aug 2024

Combining radiation with chemotherapy enhances survival in oligometastatic pancreatic cancer

Researchers from The University of Texas MD Anderson Cancer Center demonstrated that adding metastasis-directed radiation therapy to standard-of-care chemotherapy improved progression-free survival (PFS) in patients with oligometastatic pancreatic cancer.

5 Aug 2024

Breakthrough research identifies pathway used by glioblastoma to infiltrate the brain

A new pathway that is used by cancer cells to infiltrate the brain has been discovered by a team of Canadian and American research groups led by the Singh Lab at McMaster University.

2 Aug 2024

Review highlights the interplay of TGF-β and HIPPO pathways in liver regeneration and disease

The liver's ability to communicate with other organs is crucial for maintaining homeostasis, particularly through signaling pathways.

30 Jul 2024

Metastasis News and Research

Further Reading

16 promising postdoctoral scientists awarded Damon Runyon Fellowships for cancer research

Targeting cancer cells by cutting off essential nutrients and backup supplies

Olaparib effective against BRCA2-mutated prostate cancer

Fasting and ketogenic diet reveal new vulnerability of pancreatic tumors to existing cancer drug

Researchers reveal impact of genetic ancestry on breast cancer risk and cell diversity

Simplifying cell movement analysis with CellTracksColab

New nanobody shows potential in preventing lung metastasis of breast tumor cells

New research gives unprecedented view of colorectal cancer genetic makeup

Largest multi-omics study identifies new genetic landscapes in colorectal cancer

Personalized treatment strategies based on calcification status in breast cancer

Review explores potential for improved use of anti-angiogenic agents in cancer therapy

Insilico Medicine's pan-TEAD inhibitor ISM6331 receives FDA IND clearance for mesothelioma treatment

Drug shows new promise in treating breast cancer with brain metastases or recurrent glioblastoma

New insights into the role of cancer-associated fibroblasts in promoting lymphatic metastasis

Sensory nerves drive breast cancer growth and spread, study reveals

The interplay of liver cancer stem cells and immune cells in tumor microenvironment

INT-1B3 enhances anti-tumor immunity and prolongs survival in mouse models

Combining radiation with chemotherapy enhances survival in oligometastatic pancreatic cancer

Breakthrough research identifies pathway used by glioblastoma to infiltrate the brain

Review highlights the interplay of TGF-β and HIPPO pathways in liver regeneration and disease

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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