Oncogene News and Research

RSS

An oncogene is a gene that, when mutated or expressed at high levels, helps turn a normal cell into a tumor cell.

Researchers identify tantalizing target in fight against aggressive form of lung cancer

Researchers at the University of Virginia School of Medicine have discovered a flaw in the armor of the most aggressive form of lung cancer, a weakness that doctors may be able to exploit to slow or even stop the disease.

19 Aug 2016

Researchers show how p53 protein can control gene expression at levels of transcription, mRNA translation

Proteins that bind DNA or RNA are usually put in different categories, but researchers at Umea University in Sweden and Inserm in France recently showed how the p53 protein has the capacity to bind both and how this controls gene expression on the levels of both transcription (RNA synthesis) and mRNA translation (protein synthesis).

7 Aug 2016

Brazilian study discovers promising therapeutic and diagnostic target for treatment of melanoma

A Brazilian study shows that inhibition of an RNA named RMEL3, which is encoded by a previously uncharacterized gene (also named RMEL3), can reduce the viability of cultured melanoma cells by up to 95%.

4 Aug 2016

Scientists identify novel way to target lung cancer through KRAS gene

UT Southwestern Medical Center researchers have identified a new way to target lung cancer through the KRAS gene, one of the most commonly mutated genes in human cancer and one researchers have so far had difficulty targeting successfully.

29 Jul 2016

Scientists identify new genetic variations contributing to onset of APL

A study led by a team of scientists from the Cancer Science Institute of Singapore at the National University of Singapore has identified new genetic alterations contributing to the onset of Acute Promyelocytic Leukemia (APL).

27 Jul 2016

Adhesive patch can deliver triple combination therapy to tumor sites

Approximately one in 20 people will develop colorectal cancer in their lifetime, making it the third-most prevalent form of the disease in the U.S. In Europe, it is the second-most common form of cancer.

25 Jul 2016

CNIO study shows proinflammatory molecule IL-17A can be key factor in development of NASH and HCC

Non-alcoholic steatohepatitis (NASH) is a serious hepatic condition that precedes hepatocellular carcinoma (HCC) and is currently untreatable.

12 Jul 2016

JAX researchers find precise, reliable way to identify leukemia cells of origin

Every cancer starts with a single cell, and Jackson Laboratory researchers have found a precise and reliable way -- whole-genome profiling of open chromatin -- to identify the kind of cell that leads to a given case of leukemia, a valuable key to cancer prognosis and outcome.

11 Jul 2016

Scientists detect first cell from which tumour grows in skin cancers

Scientists have identified for the first time the 'cell of origin' - in other words, the first cell from which the cancer grows - in basal cell carcinoma, the most common form of skin cancer, and followed the chain of events that lead to the growth of these invasive tumours.

11 Jul 2016

Study finds microRNA let-7 plays key role in restricting neuroblastoma

Great strides have been made in treating neuroblastoma, the most common cancer in infants and toddlers. However, advanced cases are often fatal, and children who survive often face life-long physical and intellectual challenges related to their treatment.

8 Jul 2016

Mitochondrial stress can trigger tumor-related metabolic shifts, study finds

Cancerous tumors must be fed. Their unregulated growth requires a steady stream of blood flow and nutrients. Thus, one way that researchers have tried to wipe out cancer is to target cells undergoing the metabolic shifts that enable a tumor's rapid growth.

7 Jul 2016

Researchers demonstrate simple approach to prove how classes of new drugs work

A collaborative effort by cancer researchers at Cold Spring Harbor Laboratory and chemists at Boehringer Ingelheim, a pharmaceutical firm, has resulted in the identification of a new drug target in leukemia and creation of a candidate drug that hits the target.

6 Jul 2016

ALK fusion variants could influence NSCLC crizotinib response

In non-small-cell lung cancer patients with anaplastic lymphoma kinase rearrangement treated with crizotinib, progression-free survival varies according to the ALK fusion variant.

1 Jul 2016

Oncogene signatures could help design new drug treatments for breast cancer

Drug treatments for breast cancer patients might soon be designed based on the unique genetic autograph of their tumor.

25 Jun 2016

Breast cancer cells use new signaling pathway to cope with lack of oxygen levels inside tumors

Researchers have identified a new signaling pathway that helps cancer cells cope with the lack of oxygen found inside tumors. These are the results of a study published in Nature Cell Biology on June 20, and led by researchers at NYU Langone Medical Center and its Laura and Isaac Perlmutter Cancer Center, Princess Margaret Cancer Center, the University of Toronto, Harvard Medical School and Oxford University.

21 Jun 2016

Researchers reveal how cancer cells use energy to move and divide so quickly

Cancer cells and normal cells both divide and move, but with cancer cells it's like they're on steroids: everything is bigger, faster, more.

15 Jun 2016

Scientists find new way to slow growth of triple negative breast cancer

CANCER RESEARCH UK scientists have found a new way to slow the growth of the most aggressive type of breast cancer, according to research published in the journal Oncogene today (Monday).

14 Jun 2016

Study underscores importance of developing PRMT5 inhibitors as promising treatment for GB patients

A new study suggests that blocking an enzyme called PRMT5 in tumor cells could be a promising new strategy for the treatment of glioblastoma (GB), the most aggressive and lethal form of brain cancer.

14 Jun 2016

Researchers discover AF1q protein linked to multiple myeloma, EMD

A group of researchers from the University of Louisville, Japan and Austria is the first to identify a protein, AF1q, associated with multiple myeloma and a condition that occurs in approximately one-fourth of very aggressive multiple myeloma, extramedullary disease or EMD.

10 Jun 2016

Whole-exome sequencing can help characterize genetic alterations for commonly used bladder cancer cell lines

Much of basic cancer research is based on studies with cultured cancer cells. However, the usefulness of these studies greatly depends on how accurately these cancer cells grown in a dish represent human tumors.

9 Jun 2016