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Assessing the risks of thrombotic events post vaccination with ChAdOx1 and BNT162b2 vaccines in England

Researchers aim to better understand the population-level thrombotic risks post COVID-19 vaccination with both the ChAdOx1-S and BNT162b2 vaccines.

29 Aug 2021

The influence of COVID-19 on platelet activation and aggregation

In a paper recently uploaded to the bioRxiv* preprint server, humanized ACE2 mice are infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and platelets are subsequently isolated from the blood for quantitative proteomic analysis.

26 Aug 2021

Persistence of Anti-PF4 levels in VITT patients four months after AstraZeneca COVID-19 vaccine

A study published on medRxiv* preprint server reported the over-time changes in the ability of the serum to activate platelets in vitro.

25 Aug 2021

Glycyrrhizic acid as a drug candidate for COVID-19

A new study presents the benefits of licorice, an age-old herbal remedy, to treat COVID-19 at all stages.

24 Aug 2021

COVID-19 with pre-eclampsia and acute fatty liver of pregnancy

A new study reports a case of pre-eclampsia complicated by the acute fatty liver of pregnancy (AFLP).

24 Aug 2021

Nanotechnology provides novel solutions against zoonotic viruses

Therefore, scientists functionalize nanoparticles to act against these pathogenic viruses in a clinical strategy. In a recent review published in the journal Microbial Pathogenesis, researchers look at the novel solutions against zoonotic viruses provided by nanotechnology.

23 Aug 2021

Treatment with stem cell grafts promotes tendon healing in sheep

Tendon injuries in sheep that were treated with stem cell grafts achieved, in just two months, a diameter and hardness similar to the original healthy tendon, according to the results of a study released in STEM CELLS Translational Medicine.

16 Aug 2021

SARS-CoV-2 Spike may trigger production of antibodies that cross-react with human thrombopoietin to induce thrombocytopenia

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infected individuals often suffer from thrombocytopenia, a condition associated with low platelet counts. The cytokine thrombopoietin regulates platelet count. Previous studies have reported that thrombocytopenia can increase the coronavirus disease 2019 (COVID-19) mortality rate by about five times.

16 Aug 2021

Long COVID may be due to persistent immune disturbances

A new study discusses abnormalities in the immune response following COVID-19 in samples collected from patients who have recovered from COVID-19.

8 Aug 2021

Initiating therapeutic anticoagulation benefits moderately ill COVID-19 patients, but not critically ill patients

A large clinical trial conducted worldwide shows that treating moderately ill hospitalized COVID-19 patients with a full-dose blood thinner reduced their need for organ support, such as mechanical ventilation, and improved their chances of leaving the hospital.

4 Aug 2021

Simple method to assess the risk of vascular inflammation for diabetes patients

A team of international scientists from Nanyang Technological University, Singapore (NTU Singapore), Tan Tock Seng Hospital (TTSH) in Singapore, and the Massachusetts Institute of Technology (MIT) has developed a simple method of extracting tiny biological particles from a person's blood and use them as biomarkers to assess the health of their blood vessels.

27 Jul 2021

Researchers develop ovarian tumor microenvironment-chip to test novel ways to treat the disease

In the evolving field of cancer biology and treatment, innovations in organ-on-a-chip microdevices allow researchers to discover more about the disease outside the human body.

23 Jul 2021

Pre-transplant cardio-cerebrovascular diseases impact hematopoietic cell transplant outcomes

Hematopoietic cell transplantation (HCT) is a recognized treatment option for certain blood and bone marrow cancers as well as some autoimmune and hereditary disorders.

23 Jul 2021

Can platelet size predict severity and mortality in COVID-19?

The ongoing COVID-19 pandemic has baffled researchers with its propensity to cause symptoms of largely unpredictable severity in the affected individuals. An exciting new study reports on the potential predictive value of platelet size in this situation. COVID-19 patients with severe disease often develop clots in vital organs, which leads to further complications. It is known that platelet size is a good indicator of activation.

22 Jul 2021

Could aspirin intake reduce mortality risk in COVID-19 patients?

Scientists from the Michigan State University, USA, have conducted a systematic review and meta-analysis to compare mortality rate in coronavirus disease 2019 (COVID-19) patients who are aspirin users or non-users. The Findings reveal that the use of aspirin is associated with a significant reduction in overall and in-hospital mortality rates.

13 Jul 2021

Open talk about negative features of COVID-19 vaccines increases trust

Concerns have been raised about the AstraZeneca and Johnson & Johnson vaccines regarding very rare but potentially fatal side effects related to low blood platelet counts and blood clots. Recently, reports also emerged that the Pfizer-BioNTech vaccine may cause a rare yet serious side effect: heart inflammation.

9 Jul 2021

Striking increase in SARS-CoV-2 antibodies seen with prime dose AstraZeneca vaccine followed by Pfizer-BioNTech

Researchers in Germany have provided evidence that a booster shot of a messenger RNA (mRNA)-based coronavirus disease 2019 (COVID-19) vaccine following prime immunization with AstraZeneca’s adenoviral vector-based vaccine is sufficient to achieve high levels of neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

8 Jul 2021

Researchers discover how vaccine-induced immune thrombotic thrombocytopenia happens

A McMaster University team of researchers recently discovered how, exactly, the COVID-19 vaccines that use adenovirus vectors trigger a rare but sometimes fatal blood clotting reaction called vaccine-induced immune thrombotic thrombocytopenia or VITT.

7 Jul 2021

Simple blood tests may help prevent inaccuracy in the diagnosis of severe malaria

Using simple blood tests could help researchers identify children who have been misidentified as having severe malaria, according to a study published today in eLife.

6 Jul 2021

Angiotensin II type 1 receptor-targeting autoantibodies may increase COVID-19 severity

A team of US-based scientists recently demonstrated that pro-thrombotic autoantibodies that target angiotensin II type 1 receptor (AT1R) may be associated with endothelial complications observed in coronavirus disease 2019 (COVID-19), a novel disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).