Clinical Trial News and Research

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Novel experimental drug designed to silence FUS gene may help treat ALS

Using an experimental drug, researchers were able to suppress a mutated amyotrophic lateral sclerosis (ALS) gene.

24 Jan 2022

Study examines how elimination of race-based adjustments in kidney function estimates impacts clinical trials

Considerable controversy surrounds race-based algorithms in medicine - such as an adjustment for Black race in equations that estimate individuals' kidney function. A new study in CJASN has examined the impact of changes to these equations on the inclusion of Black participants in kidney disease–related clinical trials, and on the results of such trials.

24 Jan 2022

Researchers are in the race to beat Omicron

David Veesler and his lab members aren't getting much sleep these days. In the final weeks of 2021, he and his team worked around the clock to post four coronavirus papers on the preprint server bioRxiv.

24 Jan 2022

Trastuzumab combined with trimodality treatment for HER2-overexpressing esophageal cancer found to be ineffective

The NRG Oncology clinical trial NRG-RTOG 1010, studying the addition of the drug trastuzumab to chemoradiation and surgery, did not reach its primary goal of improving disease-free survival (DFS) rates for patients with HER2 overexpressing esophageal adenocarcinoma.

22 Jan 2022

Neuromuscular training intervention may help reduce injury following post-concussion return-to-play

Children's Hospital Colorado released a study today that examines the efficacy of a neuromuscular training (NMT) intervention that may lead to new treatment approaches and better outcomes for athletes when they return to playing sports after a sports-related concussion.

22 Jan 2022

Researchers develop new biological parts to shape the flow of cellular processes along DNA

Scientists at the University of Bristol have developed new biological parts that are able to shape the flow of cellular processes along DNA.

21 Jan 2022

New opportunity to induce remission of peanut allergy in young children through oral immunotherapy

A clinical trial funded by the National Institutes of Health has found that giving peanut oral immunotherapy to highly peanut-allergic children ages 1 to 3 years safely desensitized most of them to peanut and induced remission of peanut allergy in one-fifth. The immunotherapy consisted of a daily oral dose of peanut flour for 2.5 years.

21 Jan 2022

Call for pharmaceutical companies to release COVID-19 vaccine data

Scientists are beginning to grow worried about the seeming reluctance of these companies to release the raw data from the clinical trials.

21 Jan 2022

Cannabidiol found to inhibit SARS-CoV-2 infection in human cells and mice

An interdisciplinary team of researchers from the University of Chicago has found evidence that cannabidiol (CBD), a product of the cannabis plant, can inhibit infection by SARS-CoV-2 in human cells and in mice.

21 Jan 2022

Oral supplement appears to promote muscle endurance and mitochondrial health in humans

An oral supplement intended to stimulate a natural body process appears to promote muscle endurance and mitochondrial health in humans.

20 Jan 2022

U of U Health researchers assess the effectiveness of new contraceptive gel for men

University of Utah Health scientists are testing a new contraceptive gel for men. Based on preliminary research, the scientists believe the hormonal gel decreases a man’s sperm production––reducing his chances of fathering a child––without decreasing his sex drive.

20 Jan 2022

Mediterranean diet linked to lower mortality in adults over 65

A greater adherence to the Mediterranean diet which had been assessed through an index made with biomarkers during a 20-year scientific monitoring is associated with a lower mortality in adults over 65.

20 Jan 2022

UAB research outlines successful xenotransplantation of genetically modified kidneys

The University of Alabama at Birmingham Marnix E. Heersink School of Medicine announces today the first peer-reviewed research outlining the successful transplant of genetically modified, clinical-grade pig kidneys into a brain-dead human individual, replacing the recipient's native kidneys.

20 Jan 2022

MD Anderson and Yingli Pharma announce strategic alliance to advance many oncology programs

The University of Texas MD Anderson Cancer Center and Yingli Pharma US, Inc. today announced a strategic alliance to advance several oncology programs from preclinical discovery through clinical development.

20 Jan 2022

Scientists explore the possibility of Omicron ending the COVID-19 pandemic

A new analysis parses out what scientists currently know about the Delta variant and predicts what the end of the COVID-19 pandemic might look like.

20 Jan 2022

Researchers compare two psychotherapies used for treating veterans with PTSD

Cognitive processing therapy and prolonged exposure are the two leading trauma-focused cognitive behavioral psychotherapies used for Veterans Affairs patients with PTSD.

20 Jan 2022

Chatbot helped improve the health of patients whose joint replacement surgeries got delayed by COVID-19

When patients' hip or knee replacements were delayed in response to COVID-19 surges, chatbots delivering encouraging messages not only benefited the mental health of patients – they also experienced boosts to their physical health, too.

20 Jan 2022

Investigational cancer drug mimics the metabolic and therapeutic effects of fasting, mice study shows

An investigational cancer drug that starves tumors of their energy supply also shows evidence of improving whole body metabolism, according to a new study in mice from Washington University School of Medicine in St. Louis.

19 Jan 2022

Treatment with immune-boosting protein and radiation improves survival in mice with glioblastoma

Glioblastoma, an aggressive cancer in the brain or spinal cord, has proven stubbornly resistant to newer immunotherapies. And radiation and chemotherapy, the standard treatment for glioblastoma, result in fewer than 10% of patients surviving longer than five years after diagnosis.

19 Jan 2022

Independent drug action responsible for greater clinical efficacy of combination cancer therapies

Independent drug action, not synergy nor additivity, accounted for the clinical efficacy of nearly all examined combination therapies involving immune checkpoint inhibitors in clinical trials, according to results from a retrospective analysis.

19 Jan 2022

Clinical Trial News and Research

Novel experimental drug designed to silence FUS gene may help treat ALS

Study examines how elimination of race-based adjustments in kidney function estimates impacts clinical trials

Researchers are in the race to beat Omicron

Trastuzumab combined with trimodality treatment for HER2-overexpressing esophageal cancer found to be ineffective

Neuromuscular training intervention may help reduce injury following post-concussion return-to-play

Researchers develop new biological parts to shape the flow of cellular processes along DNA

New opportunity to induce remission of peanut allergy in young children through oral immunotherapy

Call for pharmaceutical companies to release COVID-19 vaccine data

Cannabidiol found to inhibit SARS-CoV-2 infection in human cells and mice

Oral supplement appears to promote muscle endurance and mitochondrial health in humans

U of U Health researchers assess the effectiveness of new contraceptive gel for men

Mediterranean diet linked to lower mortality in adults over 65

UAB research outlines successful xenotransplantation of genetically modified kidneys

MD Anderson and Yingli Pharma announce strategic alliance to advance many oncology programs

Scientists explore the possibility of Omicron ending the COVID-19 pandemic

Researchers compare two psychotherapies used for treating veterans with PTSD

Chatbot helped improve the health of patients whose joint replacement surgeries got delayed by COVID-19

Investigational cancer drug mimics the metabolic and therapeutic effects of fasting, mice study shows

Treatment with immune-boosting protein and radiation improves survival in mice with glioblastoma

Independent drug action responsible for greater clinical efficacy of combination cancer therapies

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