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NTU-incubated start-up plans clinical trial of new slow-release pill for Parkinson’s disease

Materials scientists from Nanyang Technological University, Singapore (NTU Singapore) have developed a new pill which uses the stomach as a drug reservoir and delivers medicines slowly over time to patients with Parkinson's disease (PD).

16 Sep 2020

Pfizer's anti-viral 3CL protease inhibitor shows antiviral potential against SARS-CoV-2

Now, a new study by researchers from Pfizer, University of Arizona, Purdue University, The Scripps Research Institute, and UC San Diego School of Medicine and published on the preprint server bioRxiv in September 2020 reports that an enzyme inhibitor may act in synergism with the approved antiviral remdesivir to suppress viral replication in COVID-19.

16 Sep 2020

Heparan sulfate aids COVID-19 virus to penetrate human lung cells

A molecule known as ACE2 sits like a doorknob on the outer surfaces of the cells that line the lungs. Since January 2020, researchers have known that SARS-CoV-2, the novel coronavirus that causes COVID-19, primarily uses ACE2 to enter these cells and establish respiratory infections.

16 Sep 2020

New clinical trial shows combination of two innovative precision medicines could treat multiple cancers

Launching a dual-pronged attack on tumours using a combination of two innovative precision medicines could treat patients with multiple common cancers, a new clinical trial shows.

15 Sep 2020

New nanomedicine is efficient and less aggressive than conventional prostate cancer therapy

Prostate cancer is the most common type of cancer among European men; its incidence surpasses 100 cases per 100,000 people.

15 Sep 2020

Scientists unravel the molecular mechanism underlying the causes of colorectal cancer

A team of scientists has unraveled the molecular mechanism behind one of the causes of colorectal cancer, and a treatment target.

15 Sep 2020

RCas9 gene therapy clears toxic RNA buildup in mouse model of myotonic dystrophy

Myotonic dystrophy type I is the most common type of adult-onset muscular dystrophy. People with the condition inherit repeated DNA segments that lead to the toxic buildup of repetitive RNA, the messenger that carries a gene's recipe to the cell's protein-making machinery.

14 Sep 2020

Immune system study helps illuminate a surprising mind-body connection

New research at Washington University School of Medicine in St. Louis helps illuminate a surprising mind-body connection.

14 Sep 2020

Research provides insight into how muscles and fat tissue communicate to improve fitness

Why does exercise training make you more fit? It's well established that exercising enhances insulin sensitivity and improves our metabolism that, in turn, increases exercise performance. But the biological mechanisms underlying this adaptation are not fully understood.

14 Sep 2020

Tiny antibody component shows high potency in SARS-CoV-2 animal models

University of Pittsburgh School of Medicine scientists have isolated the smallest biological molecule to date that completely and specifically neutralizes the SARS-CoV-2 virus, which is the cause of COVID-19.

14 Sep 2020

Researchers develop new PET imaging agent that spotlights inflammation

Many of the most common diseases -- cancer, diabetes, cardiovascular and lung disease, and even COVID-19 -- have been linked to chronic or excessive inflammation.

14 Sep 2020

Researchers identify microRNA molecules that could repress the replication of human coronaviruses

HSE University researchers have found microRNA molecules that are potentially capable of repressing the replication of human coronaviruses, including SARS-CoV-2.

14 Sep 2020

Cell signaling research rings warning bells over an emerging cancer drug target

Researchers at the Babraham Institute have used their understanding of cellular signalling to highlight a pitfall in an emerging treatment for cancer and inflammation.

14 Sep 2020

DNA damage may occur far away from the point of incidence of radiation

Ultraviolet light endangers the integrity of human genetic information and may cause skin cancer. For the first time, researchers of Karlsruhe Institute of Technology have demonstrated that DNA damage may also occur far away from the point of incidence of the radiation.

14 Sep 2020

Single-molecule imaging of SARS-CoV-2 spikes on virus particles

Using single-molecule FRET analysis, a team of researchers has revealed how the different conformations of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein are interconnected. Figuring out the different conformations in real-time and which conformations antibodies prefer may help design effective vaccines and drugs. The research is published on the preprint server bioRxiv*.

14 Sep 2020

Researchers identify the missing link in the production of nitric oxide

Some microorganisms, the so-called methanotrophs, make a living by oxidizing methane (CH4) to carbon dioxide (CO2). Ammonia (NH3) is structurally very similar to methane, thus methanotrophs also co-metabolize ammonia and produce nitrite.

14 Sep 2020

Combined immunotherapy approaches increase the effectiveness of cancer treatment

Cancer immunotherapy is the manipulation of the immune responses naturally present in the human body to fight cancer.

11 Sep 2020

Antibiotic molecule helps the body's own immune system to kill HIV infected cells

Ever since the first cases of a mysterious disease in the early 1980s exploded into the HIV/AIDS pandemic, researchers have been searching for ways to outsmart the deadly virus.

11 Sep 2020

Effective, simple, safe self-amplifying RNA vaccines

A recent review paper in the journal Current Opinion in Virology in September 2020 shows how a new generation of RNA vaccines called self-amplifying RNA vaccines are more potent than conventional mRNA vaccines and could hold the key to the global production of cost-effective potent COVID-19 vaccines.

11 Sep 2020

Study sheds light on how interferon-gamma drives response to immunotherapy in melanoma

A new study by researchers at the UCLA Jonsson Comprehensive Cancer Center sheds light on how interferon-gamma (IFN-y), an immune response-stimulating signaling molecule that helps activate immune cells, guides the treatment response in people with advanced melanoma who are treated with one of the leading immunotherapies - immune checkpoint blockade.

10 Sep 2020

Molecule News and Research

NTU-incubated start-up plans clinical trial of new slow-release pill for Parkinson’s disease

Pfizer's anti-viral 3CL protease inhibitor shows antiviral potential against SARS-CoV-2

Heparan sulfate aids COVID-19 virus to penetrate human lung cells

New clinical trial shows combination of two innovative precision medicines could treat multiple cancers

New nanomedicine is efficient and less aggressive than conventional prostate cancer therapy

Scientists unravel the molecular mechanism underlying the causes of colorectal cancer

RCas9 gene therapy clears toxic RNA buildup in mouse model of myotonic dystrophy

Immune system study helps illuminate a surprising mind-body connection

Research provides insight into how muscles and fat tissue communicate to improve fitness

Tiny antibody component shows high potency in SARS-CoV-2 animal models

Researchers develop new PET imaging agent that spotlights inflammation

Researchers identify microRNA molecules that could repress the replication of human coronaviruses

Cell signaling research rings warning bells over an emerging cancer drug target

DNA damage may occur far away from the point of incidence of radiation

Single-molecule imaging of SARS-CoV-2 spikes on virus particles

Researchers identify the missing link in the production of nitric oxide

Combined immunotherapy approaches increase the effectiveness of cancer treatment

Antibiotic molecule helps the body's own immune system to kill HIV infected cells

Effective, simple, safe self-amplifying RNA vaccines

Study sheds light on how interferon-gamma drives response to immunotherapy in melanoma

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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