Preclinical News and Research

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CRF to release new international journal focusing on diagnosis, treatment of structural heart disease

The Cardiovascular Research Foundation announced that it will launch a new international journal focusing on the diagnosis and treatment of structural heart disease and the importance of the heart team in managing these disorders.

11 Nov 2016

Moffitt scientists show how mathematical modeling can predict patient responses to cancer drugs

Scientists have significantly improved their understanding of cancer and have developed numerous therapies that have helped to reduce patient mortality; however, the majority of drugs that make it to the clinical trial phase of development fail, despite promising data in laboratory studies.

11 Nov 2016

Compugen program shows potential for development of new immunotherapy treatments for solid tumors

Compugen Ltd., a leading predictive drug discovery company, today presented new data for its preclinical CGEN-15029 program demonstrating the potential for the development of new cancer immunotherapy treatments for solid tumors, including the potential for drug combination with current immune checkpoint blockers.

11 Nov 2016

New research shows how synthetic DNA vaccine approach protects against Zika virus infection

As the global spread of the Zika virus continues, efforts are underway to halt the disease's transmission.

10 Nov 2016

NCATS funds collaboration initiative aimed at repurposing antimalarial to combat Ebola virus

The National Center for Advancing Translational Sciences recently awarded $596,533.00 to Collaborations Pharmaceuticals, Inc. to initiate a partnership with Texas Biomedical Research Institute aimed at repurposing an antimalarial for use against the Ebola virus.

10 Nov 2016

Experimental vaccine/immune stimulant combination may lead to viral remission in HIV patients

A study led by researchers at Beth Israel Deaconess Medical Center, in collaboration with scientists at Walter Reed Army Institute of Research, Janssen Vaccines & Prevention B.V., one of the Janssen Pharmaceutical Companies of Johnson & Johnson and Gilead Sciences, Inc., has demonstrated that combining an experimental vaccine with an innate immune stimulant may help lead to viral remission in people living with HIV.

9 Nov 2016

Investigational treatment combination improves virologic control in SIV-infected monkeys

Researchers have found that an investigational treatment combination of a therapeutic vaccine and an immune-stimulator improves virologic control and delays viral rebound following the discontinuation of antiretroviral therapy (ART) in non-human primates infected with SIV, the simian form of HIV.

9 Nov 2016

Clinical study to test safety and ability of investigational Zika vaccine candidate begins

The first of five early stage clinical trials to test the safety and ability of an investigational Zika vaccine candidate called the Zika Purified Inactivated Virus (ZPIV) vaccine to generate an immune system response has begun at the Walter Reed Army Institute of Research Clinical Trial Center in Silver Spring, Maryland.

7 Nov 2016

FDA approves expanded use of systemic therapy for treating chronic moderate-to-severe pediatric psoriasis

Amgen today announced that the U.S. Food and Drug Administration has approved the supplemental Biologics License Application for the expanded use of ENBREL (etanercept), making it the first and only systemic therapy to treat pediatric patients (ages 4-17) with chronic moderate-to-severe plaque psoriasis.

7 Nov 2016

Researchers working on breast-friendly, radiation-free method to detect possible breast cancer

Each year around a million women in the Netherlands undergo mammograms for early detection of possible breast cancer. It's an unpleasant procedure that uses X-rays. Researchers at Eindhoven University of Technology are working on a 'breast-friendly' method, without radiation, that is more accurate and generates 3D rather than 2D images.

4 Nov 2016

Transcatheter cerebral embolic protection effectively captures embolic debris and safe in TAVR patients

An international study has found that transcatheter cerebral embolic protection (TCEP) is safe, provides effective capture of embolic debris and does not change neurocognitive function for transcatheter aortic valve replacement (TAVR) patients.

2 Nov 2016

Fred Hutchinson opens first-of-its-kind clinic to provide new immunotherapies for cancer patients

Fred Hutchinson Cancer Research Center today announced the official opening of a first-of-its-kind clinic dedicated to providing innovative immunotherapies for cancer patients in clinical trials.

2 Nov 2016

Researchers identify potential new treatment for brain cancer by targeting genes linked to microcephaly

University of North Carolina Lineberger Comprehensive Cancer Center researchers have identified a potential new treatment for brain cancer by learning from a rare condition that can cause microcephaly.

1 Nov 2016

Stents can be as effective as surgery for many patients with left main coronary artery disease

A major international study has found that drug-eluting stents, a less-invasive alternative to bypass surgery, are as effective as surgery for many patients with a blockage in the left main coronary artery.

1 Nov 2016

Heart problems from common cancer treatment can be alleviated by using gene therapy

Researchers of the Wihuri Research Institute and the University of Helsinki, Finland, have found that some of the harmful effects of a commonly used cancer drug can be alleviated by using gene therapy that stimulates blood vessel growth in the heart.

31 Oct 2016

OCT offers safe and better guidance for patients undergoing PCI to treat coronary artery disease

Optical coherence tomography (OCT) provides safe and improved guidance for patients undergoing percutaneous coronary intervention to treat coronary artery disease, according to results from the ILLUMIEN III: OPTIMIZE PCI trial.

31 Oct 2016

Turning off TAZ protein in liver cells reverses fibrosis in mice

Scientists at Columbia University Medical Center have identified a factor in liver cells that is responsible for turning a relatively benign liver condition, present in 30 percent of U.S. adults, into a serious disease that can lead to liver failure.

27 Oct 2016

Biovica, Eisai sign agreement to analyze DiviTum for improved cancer drug assessment in animal models

Biovica and Eisai Inc. have entered into a lab services agreement to analyze DiviTum, an assay measuring serum thymidine kinase, for improved drug evaluation in animal cancer models.

27 Oct 2016

Physically active children in urban areas have high black carbon exposure, study finds

Children from urban areas of New York City who engaged in vigorous daily exercise had greater exposure to black carbon, a traffic-related pollutant, than children who were less active, according to a study by a multidisciplinary team of researchers from Columbia University's College of Physicians & Surgeons and Columbia's Mailman School of Public Health.

26 Oct 2016

Gene therapy may be effective method for treating Niemann-Pick disease, type C1

For the first time, National Institutes of Health researchers have demonstrated in mice that gene therapy may be the best method for correcting the single faulty gene that causes Niemann-Pick disease, type C1 (NPC1).

26 Oct 2016

Preclinical News and Research

CRF to release new international journal focusing on diagnosis, treatment of structural heart disease

Moffitt scientists show how mathematical modeling can predict patient responses to cancer drugs

Compugen program shows potential for development of new immunotherapy treatments for solid tumors

New research shows how synthetic DNA vaccine approach protects against Zika virus infection

NCATS funds collaboration initiative aimed at repurposing antimalarial to combat Ebola virus

Experimental vaccine/immune stimulant combination may lead to viral remission in HIV patients

Investigational treatment combination improves virologic control in SIV-infected monkeys

Clinical study to test safety and ability of investigational Zika vaccine candidate begins

FDA approves expanded use of systemic therapy for treating chronic moderate-to-severe pediatric psoriasis

Researchers working on breast-friendly, radiation-free method to detect possible breast cancer

Transcatheter cerebral embolic protection effectively captures embolic debris and safe in TAVR patients

Fred Hutchinson opens first-of-its-kind clinic to provide new immunotherapies for cancer patients

Researchers identify potential new treatment for brain cancer by targeting genes linked to microcephaly

Stents can be as effective as surgery for many patients with left main coronary artery disease

Heart problems from common cancer treatment can be alleviated by using gene therapy

OCT offers safe and better guidance for patients undergoing PCI to treat coronary artery disease

Turning off TAZ protein in liver cells reverses fibrosis in mice

Biovica, Eisai sign agreement to analyze DiviTum for improved cancer drug assessment in animal models

Physically active children in urban areas have high black carbon exposure, study finds

Gene therapy may be effective method for treating Niemann-Pick disease, type C1

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