Efficacy News and Research

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Researchers share results of MVA-BN-respiratory syncytial virus vaccine human challenge trial

Researchers reported the immunogenicity, efficacy, and safety of the MVA-BN (modified vaccinia Ankara-Bavarian Nordic)-RSV (respiratory syncytial virus) vaccine against RSV-A (RSV subtype A) Memphis 37b strain in a human challenge trial.

7 Dec 2022

Study reports overall response of HER2-low breast cancer patients to neoadjuvant T-DXd treatment

Patients with localized, hormone receptor-positive, HER2-low breast cancer treated with trastuzumab deruxtecan (T-DXd, Enhertu) in the neoadjuvant setting had an overall response rate of 75 percent in the absence of anastrozole and 63 percent in combination with anastrozole, according to results from the phase II TRIO-US B-12 TALENT trial presented at the San Antonio Breast Cancer Symposium, held December 6-10, 2022.

7 Dec 2022

Exploring immunogenicity, boosting efficacy and safety of modified vaccinia Ankara-Bavarian Nordic vaccine

Researchers evaluated the immunogenicity, boosting efficacy, and safety of single-dose and two-dose MVA-BN (modified vaccinia Ankara-Bavarian Nordic) vaccinations in comparison to replicating smallpox vaccines.

7 Dec 2022

Innovative precision oncology enabled by micro-organospheres derived from patients

The development of an automatic microfluidics droplet platform to rapidly generate patient-derived models of cancer.

6 Dec 2022

COVID-19 vaccination may cause temporary menstrual disturbances in adolescent girls

The Pfizer-BioNTech mRNA-based COVID-19 vaccine may increase the risk of menstrual disturbances in adolescent girls in their first cycle after vaccination.

6 Dec 2022

Study suggests new anti-KRAS drug as a strong candidate for pancreatic cancer clinical trials

A small molecule inhibitor that attacks the difficult to target, cancer-causing gene mutation KRAS, found in nearly 30 percent of all human tumors, successfully shrunk tumors or stopped cancer growth in preclinical models of pancreatic cancer, researchers from Penn Medicine's Abramson Cancer Center showed, suggesting the drug is a strong candidate for clinical trials.

6 Dec 2022

Higher dose of new antimalarial drug reduces disease recurrence by 85%

A new antimalarial drug is being introduced at a dose that is too low to be effective for all patients who need it, according to a report published today in eLife.

6 Dec 2022

The critical role of flow cytometry in CAR+ T-Cell trials

In this interview, Ryan Muise talks to AZoNetwork about the added value of using flow cytometry in CAR T-Cell clinical trials.

From Cerba Research 6 Dec 2022

Is remdesivir treatment associated with reduced risk of inpatient mortality among US patients hospitalized with COVID-19?

Researchers assessed the effect of remdesivir on inpatient COVID-19-associated mortality among individuals hospitalized with SARS-CoV-2 infections in an enormous dataset of US residents beyond clinical trial settings.

6 Dec 2022

MHRA authorizes the use of Pfizer/Biontech COVID-19 vaccine in kids aged 6 months to 4 years

Authorization has today been granted for a new presentation of the Pfizer/BioNTech COVID-19 vaccine (Comirnaty) for use in infants and children aged 6 months to 4 years.

6 Dec 2022

Vaccine MVA-BN shows consistent, robust immunogenicity and safety results

A phase III clinical trial showed consistent immunogenicity for a freeze-dried formulation of Bavarian Nordic's Modified Vaccinia Ankara.

5 Dec 2022

Researchers develop a polyvalent lipid nanoparticle mRNA vaccine against Monkeypox virus

Researchers developed an mRNA technology-based vaccine candidate against the monkeypox virus and evaluated its immunogenicity in animal models.

5 Dec 2022

Researchers uncover the host protease CAPN2 as a novel host factor that aids the infection of SARS-CoV-2

Researchers investigated the potential of the CAPN2 molecule as a therapeutic target against SARS-CoV-2.

5 Dec 2022

Trial shows acoziborole drug clears body of African sleeping sickness parasites

Researchers evaluate the efficacy and safety of an oral antimicrobial drug acoziborole in patients with human African trypanosomiasis.

4 Dec 2022

Researchers develop potent yet low-inflammatory mRNA cancer vaccine vectors

Lipid nanoparticle (LNP)-based messenger ribonucleic acid (mRNA) vaccines have recently emerged as a promising strategy for the prevention and treatment of cancers, as well as infectious diseases.

4 Dec 2022

Mucosal IgA fused nanobody as a non-invasive, cost-effective prophylaxis and therapeutic option against major SARS-CoV-2 variants

Researchers from the United States developed an affordable, non-invasive, inhalable prophylactic treatment consisting of immunoglobulin (Ig) A fused nanobodies against the SARS-CoV-2 Omicron variant.

2 Dec 2022

Exploring the effects of dietary fiber on gut microbiome and inflammatory diseases

Researchers reviewed how dietary fibers modulate the composition and function of gut microbiota.

2 Dec 2022

Vaccination against pertussis in pregnancy and outstanding scientific questions

A recent paper published in Vaccines summarized the data presented and the discussions in the meeting regarding pertussis vaccination in pregnancy (ViP).

2 Dec 2022

Collaborative work unravels hidden molecular secrets of age-related diseases

Insilico Medicine, a clinical-stage end-to-end artificial intelligence (AI)-driven drug discovery company, and the University of Copenhagen announced today the release of the first batch of results from the collaborative work directed to perform multi-omics-based analyses in the context of age-related diseases using an AI-driven target and drug discovery pipeline.

2 Dec 2022

The business of clinical trials is booming. Private equity has taken notice.

After finding success investing in the more obviously lucrative corners of American medicine — like surgery centers and dermatology practices — private equity firms have moved aggressively into the industry's more hidden niches: They are pouring billions into the business of clinical drug trials.

2 Dec 2022

Efficacy News and Research

Researchers share results of MVA-BN-respiratory syncytial virus vaccine human challenge trial

Study reports overall response of HER2-low breast cancer patients to neoadjuvant T-DXd treatment

Exploring immunogenicity, boosting efficacy and safety of modified vaccinia Ankara-Bavarian Nordic vaccine

Innovative precision oncology enabled by micro-organospheres derived from patients

COVID-19 vaccination may cause temporary menstrual disturbances in adolescent girls

Study suggests new anti-KRAS drug as a strong candidate for pancreatic cancer clinical trials

Higher dose of new antimalarial drug reduces disease recurrence by 85%

The critical role of flow cytometry in CAR+ T-Cell trials

Is remdesivir treatment associated with reduced risk of inpatient mortality among US patients hospitalized with COVID-19?

MHRA authorizes the use of Pfizer/Biontech COVID-19 vaccine in kids aged 6 months to 4 years

Vaccine MVA-BN shows consistent, robust immunogenicity and safety results

Researchers develop a polyvalent lipid nanoparticle mRNA vaccine against Monkeypox virus

Researchers uncover the host protease CAPN2 as a novel host factor that aids the infection of SARS-CoV-2

Trial shows acoziborole drug clears body of African sleeping sickness parasites

Researchers develop potent yet low-inflammatory mRNA cancer vaccine vectors

Mucosal IgA fused nanobody as a non-invasive, cost-effective prophylaxis and therapeutic option against major SARS-CoV-2 variants

Exploring the effects of dietary fiber on gut microbiome and inflammatory diseases

Vaccination against pertussis in pregnancy and outstanding scientific questions

Collaborative work unravels hidden molecular secrets of age-related diseases

The business of clinical trials is booming. Private equity has taken notice.

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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