Preclinical News and Research

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Scientists uncover new class of small molecules for fighting urinary tract infection

This spring, a Pennsylvania woman who developed a urinary tract infection (UTI) became the first patient in the U.S. reported to have a bacterial infection resistant to colistin, an antibiotic of last resort.

26 Oct 2016

Study finds increased risk of pregnancy-associated stroke among young women

Pregnancy was not found to raise the risk of stroke in older women, according to a study from Columbia University Medical Center and NewYork-Presbyterian. In younger women, however, the risk of stroke was significantly higher for those who were pregnant.

25 Oct 2016

Adherence to medical therapy linked to better outcomes for patients who had heart procedures

Patients who had a stent procedure or heart bypass surgery and continued with their prescribed medical therapy had significantly better outcomes than non-adherent patients, according to a study published today in the journal Circulation.

24 Oct 2016

Screening for prolactin receptor could help improve TNBC prognosis and treatment

A study conducted at the Research Institute of the McGill University Health Centre suggests screening breast cancer patients for the prolactin receptor could improve the prognosis for patient and may help them avoid unnecessary and invasive treatments

24 Oct 2016

TxCell collaborates with UBC to develop CAR-Treg therapy to prevent graft rejection in organ transplantation

TxCell SA, a biotechnology company developing innovative, personalized cellular immunotherapies using regulatory T cells (Treg) to treat severe chronic inflammatory and autoimmune diseases, today announces the signature of a strategic R&D collaboration agreement with the University of British Columbia (UBC) in Vancouver, Canada, a leading global center for multidisciplinary research and teaching.

24 Oct 2016

Scientists discover new option for treating malignant pleural mesothelioma

Researchers at the Comprehensive Cancer Center of MedUni Vienna and Vienna General Hospital have discovered a new option for treating malignant pleural mesothelioma.

24 Oct 2016

Novel lipid-based therapeutic shows promise for combating drug resistance in AML

Researchers at the Medical University of South Carolina Hollings Cancer Center have discovered a mechanism that confers resistance to drugs used to treat certain types of acute myeloid leukemia (AML).

24 Oct 2016

New research examines use of nanotechnology to improve delivery of drugs to HIV patients

New research led by the University of Liverpool aims to improve the administration and availability of drug therapies to HIV patients through the use of nanotechnology.

21 Oct 2016

Esperite's business unit develops therapy for Crohn's disease perianal fistulas

Esperite's business unit The Cell Factory in collaboration with Women's and Children's Health Department of the University of Padua and the Padua University Hospital are developing therapies for inflammatory bowel disease (IBD) using extracellular vesicles (EVs).

21 Oct 2016

Two leading non-profit organizations sign strategic affiliation to hasten drug development

The Scripps Research Institute and the California Institute for Biomedical Research - two leading non-profit research organizations - today announced the signing of a strategic affiliation that combines the two organizations into a new biomedical research entity with the tools and know-how to rapidly translate its scientific discoveries into life-saving medicines for the public benefit.

20 Oct 2016

Natural compound isolated from onions contains anti-ovarian cancer properties, research finds

Research from Kumamoto University, Japan has found that a natural compound isolated from onions, onionin A (ONA), has several anti-ovarian cancer properties.

20 Oct 2016

Domain Therapeutics and Medicxi partner to launch Mavalon Therapeutics

Domain Therapeutics, a biopharmaceutical company that specializes in the discovery and development of G protein-coupled receptor (GPCR) drugs, today announces the creation of Mavalon Therapeutics, a company focused on stopping the progression of Parkinson’s disease.

19 Oct 2016

BUSM researcher receives nearly $20 million grant to support dementia and AD research

Sudha Seshadri, MD, professor of neurology at Boston University School of Medicine, has been awarded three grants this year totaling nearly $20 million from the National Institute on Aging and the National Institute of Neurological Disorders and Stroke.

18 Oct 2016

$New review looks at complexity of fracture epidemiology in diabetes$

New review looks at complexity of fracture epidemiology in diabetes

Due to the ageing of populations as well as increasing obesity and adverse lifestyle factors, type 2 diabetes (T2D) is reaching epidemic proportions in many parts of the world.

17 Oct 2016

NAC improves effectiveness of adoptive cell therapy for treating melanoma

A collaborative team of investigators at the Medical University of South Carolina and Loyola University have demonstrated for the first time that culturing T cells in N-acetyl cysteine (NAC) before they are infused as immunotherapy improves effectiveness and outcomes in a preclinical model of melanoma. These findings were reported in the October 15, 2016 issue of Cancer Research.

17 Oct 2016

RT-IMRI guidance improves safety, efficacy of stem cell treatment for Parkinson's disease

In a study using Real-time intraoperative magnetic resonance imaging (RT-IMRI) to guide the transplantation of induced pluripotent stem cell (iPSC)-derived neurons into the brains of non-human primates modeled with Parkinson's disease, researchers found that RT-IMRI guidance not only allows for better visualization and monitoring of the procedure, but also helps cell survival.

13 Oct 2016

Novel biomarkers enhance power to predict therapeutic efficacy in LN prognostic models

Results of preclinical studies by investigators at the Medical University of South Carolina reported in the August 2016 issue of Arthritis & Rheumatology demonstrate for the first time that including novel biomarkers in lupus nephritis (LN) prognostic models significantly increases their power to predict therapeutic efficacy.

12 Oct 2016

Study of pan-FGFR inhibitor uses mRNA in tumours to identify responders

The first-in-human dose escalation study of the pan-FGFR (fibroblast growth factor receptor) inhibitor BAY 1163877 in patients with treatment-refractory locally advanced or metastatic solid tumours were reported today at the ESMO 2016 Congress in Copenhagen.

8 Oct 2016

Ethosomes may be effective carrier system for transdermal delivery

Ethosomes are ethanolic nanovesicles that possess abundant amount of ethanol in its core which provides fluidity to the lipid bilayers and thus by this effect, improves the delivery of molecules into the deep skin layers.

7 Oct 2016

JAK inhibitors show promise in restoring hair growth in patients with alopecia areata

Seventy-five percent of patients with moderate to severe alopecia areata--an autoimmune disease that causes patchy, and less frequently, total hair loss--had significant hair regrowth after treatment with ruxolitinib, reported researchers from Columbia University Medical Center. By the end of their treatment, average hair regrowth was 92 percent.

5 Oct 2016

Preclinical News and Research

Scientists uncover new class of small molecules for fighting urinary tract infection

Study finds increased risk of pregnancy-associated stroke among young women

Adherence to medical therapy linked to better outcomes for patients who had heart procedures

Screening for prolactin receptor could help improve TNBC prognosis and treatment

TxCell collaborates with UBC to develop CAR-Treg therapy to prevent graft rejection in organ transplantation

Scientists discover new option for treating malignant pleural mesothelioma

Novel lipid-based therapeutic shows promise for combating drug resistance in AML

New research examines use of nanotechnology to improve delivery of drugs to HIV patients

Esperite's business unit develops therapy for Crohn's disease perianal fistulas

Two leading non-profit organizations sign strategic affiliation to hasten drug development

Natural compound isolated from onions contains anti-ovarian cancer properties, research finds

Domain Therapeutics and Medicxi partner to launch Mavalon Therapeutics

BUSM researcher receives nearly $20 million grant to support dementia and AD research

New review looks at complexity of fracture epidemiology in diabetes

NAC improves effectiveness of adoptive cell therapy for treating melanoma

RT-IMRI guidance improves safety, efficacy of stem cell treatment for Parkinson's disease

Novel biomarkers enhance power to predict therapeutic efficacy in LN prognostic models

Study of pan-FGFR inhibitor uses mRNA in tumours to identify responders

Ethosomes may be effective carrier system for transdermal delivery

JAK inhibitors show promise in restoring hair growth in patients with alopecia areata

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