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New drug targeting LF and onchocerciasis begins its first in human trial in Liverpool

A new drug developed by an LSTM led partnership, which targets the neglected tropical diseases lymphatic filariasis and onchocerciasis has begun its first in human trial.

6 Jan 2022

Study examines if antidepressants can benefit patients with osteoarthritis

A clinical trial published in Arthritis & Rheumatology recently examined whether duloxetine, a medication that is prescribed to treat depression and may also reduce chronic pain, can benefit patients with hip or knee osteoarthritis.

6 Jan 2022

How diet, supplements and lifestyle changes can help battle COVID

A recent editorial in the journal Nutrients emphasizes how efficacious non-pharmacological interventions in conjunction with the promotion of healthy lifestyle and dietary patterns may improve overall health status and reduce the risk of infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as well as the potential adverse effects of coronavirus disease 2019 (COVID-19).

6 Jan 2022

LIVE-AIR trial demonstrates efficacy of Lenzilumab for treatment of COVID patients with decreased oxygen saturation

The LIVE-AIR phase 3 clinical trial is associated with early treatment of hyperinflammatory response with the humanized monoclonal antibody lenzilumab in COVID-19 patients with decreased oxygen saturation. The study results are posted to the medRxiv* preprint server.

6 Jan 2022

Folic acid-like drug reprograms DNA methylome of aggressive brain tumors

A folic acid-like drug, L-methylfolate, when administered alongside the standard therapy for patients with recurrent glioblastoma, changed aDNA process within their brain tumors, according to results from a phase 1 clinical trial.

5 Jan 2022

Study leads to reduction in the number of medicines prescribed for older people

A study by researchers at RCSI University of Medicine and Health Sciences of GP-delivered medication for older people led to an overall reduction in the number of medicines prescribed.

5 Jan 2022

Wistar announces initiation of Phase 2 clinical study of VK-2019 in patients with advanced head and neck cancer

The Wistar Institute announces the initiation of a Phase 2 clinical study of VK-2019 in patients with advanced Epstein-Barr Virus (EBV)-positive nasopharyngeal carcinoma (NPC) and lymphoma.

5 Jan 2022

Homeschooling improved sleep and health-related quality of life for teenagers

The school closures in spring 2020 had a negative effect on the health and well-being of many young people.

5 Jan 2022

Research demonstrates the safety, feasibility of psilocybin administered at doses of 10mg or 25mg

New research from the Institute of Psychiatry, Psychology, & Neuroscience (IoPPN) at King's College London, in partnership with COMPASS Pathways, has established that psilocybin can be safely administered at doses of either 10mg or 25mg to up to six participants simultaneously.

4 Jan 2022

Depression screening highly effective at identifying breast cancer patients in need of mental health care

Kaiser Permanente research published January 4, 2022, in JAMA showed depression screening for patients with newly diagnosed breast cancer was highly effective at identifying patients in need of behavioral health care, and the new screening initiative was subsequently and successfully built into the patient care and daily workflow of medical oncology teams at Kaiser Permanente in Southern California.

4 Jan 2022

In vitro effect of several antiviral drugs against various SARS-CoV-2 variants of concern

An independent study confirms that current and prospective antiviral treatments are effective in inhibiting severe infection from SARS-CoV-2.

4 Jan 2022

Very high rates of asymptomatic infection with Omicron compared to prior SARS-CoV-2 variants

The advent of the B.1.1.529 (Omicron) severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) variant, detected initially in Botswana and South Africa and now found in over 135 countries as of January 3, 2022, has sparked fears of a new global wave of infections and hospitalizations

3 Jan 2022

Engineer receives $2.1 million grant to test a treatment strategy for children with cerebral palsy

Mechanical engineer and inventor Zach Lerner, assistant professor in Northern Arizona University's Department of Mechanical Engineering, has been awarded $2.1 million by the National Institutes of Health's Eunice Kennedy Shriver National Institute of Child Health & Human Development.

3 Jan 2022

WHO lists the Comirnaty COVID-19 mRNA vaccine for emergency use

The World Health Organization today listed the Comirnaty COVID-19 mRNA vaccine for emergency use, making the Pfizer/BioNTech vaccine the first to receive emergency validation from WHO since the outbreak began a year ago.

2 Jan 2022

A reliable assessment of COVID-19 vaccine protection duration

Researchers from the University of North Carolina, University of Washington, and the US Food and Drug Administration propose fitting a Cox model with two time indexes, the event times measured from the start of the study in calendar time and the log hazard for the vaccine effect.

30 Dec 2021

Once-a-day antiretroviral medicine for children proven to be more effective at suppressing HIV

A once-a-day antiretroviral medicine that is low-cost and easy for children to take is also more effective at suppressing HIV than standard treatments, according to a global trial led by researchers at UCL.

30 Dec 2021

Single-patient pilot study shows the ability of antisense oligonucleotide to suppress mutant ALS gene

Using a short, synthetic chain of chemically modified nucleotides engineered in the RNA Therapeutics Institute at UMass Chan Medical School, Robert H. Brown Jr., DPhil, MD, Jonathan Watts, PhD, and colleagues have shown the ability to suppress mutant forms of an ALS gene known as C9ORF72 in a single-patient pilot study.

24 Dec 2021

Ad5-nCoV vaccine safe and effective against symptomatic, severe COVID-19, trials shows

One dose of Ad5-nCoV (Convidecia), a COVID-19 vaccine developed in China, is 57.5% effective against symptomatic COVID-19 and 91.7% effective against severe COVID-19 disease beginning 28 days postvaccination, according to a phase 3 randomized controlled trial published in The Lancet.

23 Dec 2021

Study points toward an alternative drug strategy to stall Alzheimer’s neurodegeneration

Boosting levels of the neurotransmitter norepinephrine with atomoxetine, a repurposed ADHD medication, may be able to stall neurodegeneration in people with early signs of Alzheimer's disease, a study conducted at Emory Brain Health Center suggests.

22 Dec 2021

Amino acid valine plays a key role in the growth of T cell acute lymphoblastic leukemia

A molecular building block of many animal proteins, the amino acid valine, plays a key role in cancerous growth seen in T cell acute lymphoblastic leukemia, a new study shows.

22 Dec 2021

Clinical Trial News and Research

New drug targeting LF and onchocerciasis begins its first in human trial in Liverpool

Study examines if antidepressants can benefit patients with osteoarthritis

How diet, supplements and lifestyle changes can help battle COVID

LIVE-AIR trial demonstrates efficacy of Lenzilumab for treatment of COVID patients with decreased oxygen saturation

Folic acid-like drug reprograms DNA methylome of aggressive brain tumors

Study leads to reduction in the number of medicines prescribed for older people

Wistar announces initiation of Phase 2 clinical study of VK-2019 in patients with advanced head and neck cancer

Homeschooling improved sleep and health-related quality of life for teenagers

Research demonstrates the safety, feasibility of psilocybin administered at doses of 10mg or 25mg

Depression screening highly effective at identifying breast cancer patients in need of mental health care

In vitro effect of several antiviral drugs against various SARS-CoV-2 variants of concern

Very high rates of asymptomatic infection with Omicron compared to prior SARS-CoV-2 variants

Engineer receives $2.1 million grant to test a treatment strategy for children with cerebral palsy

WHO lists the Comirnaty COVID-19 mRNA vaccine for emergency use

A reliable assessment of COVID-19 vaccine protection duration

Once-a-day antiretroviral medicine for children proven to be more effective at suppressing HIV

Single-patient pilot study shows the ability of antisense oligonucleotide to suppress mutant ALS gene

Ad5-nCoV vaccine safe and effective against symptomatic, severe COVID-19, trials shows

Study points toward an alternative drug strategy to stall Alzheimer’s neurodegeneration

Amino acid valine plays a key role in the growth of T cell acute lymphoblastic leukemia

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