Preclinical News and Research

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Researchers identify new way to prevent chemotherapy resistance in lung and breast cancers

Researchers at the University of Bradford have discovered a way to prevent chemotherapy resistance in lung cancer by blocking a protein found in cancer cells.

4 Oct 2016

Yale researchers discover new blocking mechanism to inhibit lung tumors

Lung cancer cell growth depends on certain proteins that require the addition of sugar molecule chains to become active.

4 Oct 2016

Two Zika vaccine candidates protect newborn mice against neurological damage

Two vaccines against Zika virus developed at the University of Pittsburgh School of Medicine have successfully conveyed immunity from female mice to pups conceived weeks after the mother's vaccination.

4 Oct 2016

Columbia researchers discover genes that may cause gum disease

Researchers at Columbia University College of Dental Medicine Columbia University Medical Center have identified 41 master regulator genes that may cause gum disease, also known as periodontal disease. The study was the first of its kind to employ genome-wide reverse engineering to identify the gene pathways that contribute to periodontitis.

4 Oct 2016

UEF research shows retinal changes may be detected earlier than brain changes

Diseases of the central nervous system (CNS) may manifest as pathological changes in the retina of the eye.

3 Oct 2016

Developing a Micro-CT Scanner for Preclinical Imaging

An interview with Phil Salmon from Bruker, discussing the development of the SKYSCAN 1276, an in vivo micro-CT scanner designed for preclinical applications.

From Bruker BioSpin Group 3 Oct 2016

Inhibiting single protein could help restore sensitivity to common treatment for breast cancer

A team of investigators led by researchers at Georgetown Lombardi Comprehensive Cancer Center has found, in animal models of human breast cancer, that inhibiting a single protein restores sensitivity to tamoxifen, a commonly used drug for treatment of some breast cancers.

3 Oct 2016

Graded aerobic treadmill testing safe, tolerable in young patients with sports-related concussion

Graded aerobic treadmill testing is safe, tolerable, and useful in evaluating and managing cases of sports-related concussion in children and adolescents.

3 Oct 2016

GUMC receives FDA clearance to begin clinical study of cancer drug in patients with Alzheimer's disease

Georgetown University Medical Center today announces the U.S. Food and Drug Administration has completed its review of an investigational new drug application (IND) for the use of nilotinib in a phase II clinical trial for patients with mild to moderate Alzheimer's disease.

30 Sep 2016

DHA intake can prevent known trigger of lupus, study finds

A team of Michigan State University researchers has found that consuming an omega-3 fatty acid called DHA, or docosahexaenoic acid, can stop a known trigger of lupus and potentially other autoimmune disorders.

30 Sep 2016

Researchers uncover key factor for promoting wound healing after corneal injuries

In cases of severe ocular trauma involving the cornea, wound healing occurs following intervention, but at the cost of opaque scar tissue formation and damaged vision. Recent research has shown that mesenchymal stem cells (MSCs) — which can differentiate into a variety of cells, including bone, cartilage, muscle and fat cells — are capable of returning clarity to scarred corneas; however, the mechanisms by which this happens remained a mystery — until now.

29 Sep 2016

ADDF awards $2.1 million grant for clinical study of cancer drug in Alzheimer's patients

The Alzheimer's Drug Discovery Foundation announces a $2.1 million grant awarded to R. Scott Turner, MD, PhD, of Georgetown University Medical Center to conduct a phase II clinical trial of low-dose nilotinib (marketed as Tasigna for use as a cancer therapy) in patients with Alzheimer's disease.

29 Sep 2016

Gene therapy for LPLD patients linked to lower frequency and severity of pancreatitis

Up to 6 years after receiving a single treatment with the gene therapy product lipoprotein lipase (LPL), patients with the debilitating genetic disease LPL deficiency (LPLD) had about 50% fewer episodes of pancreatitis than before receiving the treatment.

28 Sep 2016

CUMC researchers uncover new details of intracellular channel that controls skeletal muscle

Using high-resolution electron microscopy, Columbia University Medical Center researchers have uncovered new details of the structure and function of an intracellular channel that controls the contraction of skeletal muscle.

22 Sep 2016

JAK inhibitors may be first effective treatment for people with alopecia areata

Seventy-five percent of patients with moderate to severe alopecia areata—an autoimmune disease that causes patchy, and less frequently, total hair loss—had significant hair regrowth after treatment with ruxolitinib, reported researchers from Columbia University Medical Center. By the end of their treatment, average hair regrowth was 92 percent.

22 Sep 2016

Duke, Wisconsin and UAB researchers create bioengineered patches to treat heart failure

The heart cannot regenerate muscle tissue after a heart attack has killed part of the muscle wall, and that dead tissue can strain surrounding muscle, leading to a lethal heart enlargement.

22 Sep 2016

MR Solutions receives order for cryogen-free 7T simultaneous PET-MR preclinical imaging system

MR Solutions has received an order for a high-powered 7T, cryogen-free, preclinical PET-MRI multi-modality imaging system from the newly formed pre-clinical imaging resource at the Zilkha Neurogenetic Institute (ZNI) at the Keck School of Medicine of the University of Southern California (USC).

21 Sep 2016

Scientists use novel theranostics technique for early thromboembolism diagnosis and treatment

Researchers from the University of Arkansas for Medical Science (USA), in collaboration with University Hospital Frankfurt and University Hospital Dresden, under the supervision of Prof. Vladimir Zharov and with the participation of Alexander Melerzanov, the dean of Department of Biological and Medical Physics (MIPT), conducted experiments on mice to detect blood clotting using photoacoustic flow-cytometry.

21 Sep 2016

Researchers propose new way for early diagnosis of neurodegenerative diseases

A preclinical test that may open new perspectives in the diagnosis of neurological disorders. This is the result accomplished by a group of researchers from the Center of Complexity and Biosystems of the University of Milan, who just published their work on 'Physical Review Applied'.

21 Sep 2016

Researchers develop new model to map links between salmonella and sepsis

Research by industrial engineering and biology researchers at Kansas State University marks a significant milestone in the battle against sepsis, the second highest cause of death in intensive care units in the U.S.

16 Sep 2016

Preclinical News and Research

Researchers identify new way to prevent chemotherapy resistance in lung and breast cancers

Yale researchers discover new blocking mechanism to inhibit lung tumors

Two Zika vaccine candidates protect newborn mice against neurological damage

Columbia researchers discover genes that may cause gum disease

UEF research shows retinal changes may be detected earlier than brain changes

Developing a Micro-CT Scanner for Preclinical Imaging

Inhibiting single protein could help restore sensitivity to common treatment for breast cancer

Graded aerobic treadmill testing safe, tolerable in young patients with sports-related concussion

GUMC receives FDA clearance to begin clinical study of cancer drug in patients with Alzheimer's disease

DHA intake can prevent known trigger of lupus, study finds

Researchers uncover key factor for promoting wound healing after corneal injuries

ADDF awards $2.1 million grant for clinical study of cancer drug in Alzheimer's patients

Gene therapy for LPLD patients linked to lower frequency and severity of pancreatitis

CUMC researchers uncover new details of intracellular channel that controls skeletal muscle

JAK inhibitors may be first effective treatment for people with alopecia areata

Duke, Wisconsin and UAB researchers create bioengineered patches to treat heart failure

MR Solutions receives order for cryogen-free 7T simultaneous PET-MR preclinical imaging system

Scientists use novel theranostics technique for early thromboembolism diagnosis and treatment

Researchers propose new way for early diagnosis of neurodegenerative diseases

Researchers develop new model to map links between salmonella and sepsis

New Approach Methodologies, the 3Rs and Multimodal Imaging in Preclinical Research - eBook eBook

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