Clinical Trial News and Research

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Protein-based nanoparticle vaccines for protection against SARS-CoV-2

A recent review article discusses recent advances in protein-based nanoparticle vaccines against SARS-CoV-2.

22 Dec 2021

UK government signs two new deals to combat the Omicron variant

Millions more cutting-edge antiviral treatments for COVID-19 have been secured for NHS patients as the UK Government signs two new contracts to help tackle Omicron.

22 Dec 2021

Clinical trial results do not support the use of fish oil supplements to prevent depression

Results from the largest clinical trial of its kind do not support the use of fish oil supplements - a source of omega-3 fatty acid - to help prevent depression.

21 Dec 2021

Doctors advised to prescribe fewer antidepressants and for shorter periods of time

Doctors should prescribe fewer antidepressants and for shorter periods of time, because of the ongoing uncertainties about their effectiveness and the potential severity and durability of the withdrawal symptoms associated with them, suggests a review of the evidence on antidepressant use, published online in the Drug and Therapeutics Bulletin.

21 Dec 2021

Early administration of SARS-CoV-2 convalescent plasma reduces outpatient hospitalizations

The results of a nationwide, multicenter clinical trial led by Johns Hopkins Medicine and the Johns Hopkins Bloomberg School of Public Health provides solid evidence for the use of plasma from convalescent patients — those who have recovered from the disease and whose blood contains antibodies against SARS-CoV-2, the virus that causes COVID-19 — as an early treatment.

21 Dec 2021

Moving more often is beneficial for long-term weight maintenance in older adults

When considered alongside the current Physical Activity Guidelines for Americans, new findings suggest that focusing less on structured exercise, and more on building frequent periods of enjoyable movement into the day, will more likely contribute to health benefits that can be sustained, according to a paper published online in Obesity, The Obesity Society's flagship journal.

21 Dec 2021

$Clinical trial shows preliminary efficacy of all-oral regimen for patients with lenalidomide-refractory multiple myeloma$

Clinical trial shows preliminary efficacy of all-oral regimen for patients with lenalidomide-refractory multiple myeloma

Early results from an Alliance for Clinical Trials in Oncology randomized clinical trial of adults with multiple myeloma relapsing on frontline lenalidomide therapy showed that adding ixazomib (Ninlaro®) to pomalidomide and dexamethasone as part of second line therapy extended the length of time patients lived before their disease worsened (progression-free survival) compared with patients who received pomalidomide and dexamethasone.

21 Dec 2021

Study focuses on inherited Alzheimer’s up to 25 years before expected dementia onset

Washington University School of Medicine in St. Louis is launching an international clinical trial aimed at preventing Alzheimer's disease in people genetically destined to develop the illness at a young age. Unlike most other Alzheimer's prevention trials, this one will enroll people before the disease has taken hold - up to 25 years before the expected onset of dementia.

21 Dec 2021

SGLT2 inhibitor empagliflozin can be used to treat insulin resistance in the brain, finds study

Overweight or obesity, an unfavorable distribution of fat in the body and the development of type 2 diabetes are often associated with a reduced effect of the hormone insulin in many organs, including the brain (insulin resistance).

21 Dec 2021

Researchers find a digital silver lining in failed COVID-19 drug trial

A clinical trial in which two test drugs failed to help patients with mild COVID-19 nevertheless had a silver lining: It proved the viability of a study model in which a medication's potential arrhythmic side effects are safely, effectively monitored without the participants ever setting foot in a hospital or clinic.

20 Dec 2021

Efficacy of SARS-CoV2 variant-specific replicating RNA vaccines on SARS-CoV-2 variants of concern

A new study evaluates the repRNA vaccine expressing the SARS-CoV-2 spike protein for the B.1.1.7 and B.1.351 variants in mice and hamsters.

19 Dec 2021

Study examines the effects of methylphenidate on mental fatigue in multiple sclerosis patients

A team of researchers at Kessler Foundation studied the effects of methylphenidate on mental fatigue in individuals with multiple sclerosis (MS). This is the first study to examine the psychostimulant's effects on 'state' vs 'trait' mental fatigue in MS.

18 Dec 2021

Scientists develop new immunotherapy for cancer based on transplant rejection mechanism

A team of scientists at the University of Oslo, Oslo University Hospital Radiumhospitalet and Karolinska Institutet, led by Professor Johanna Olweus, has developed a new type of immunotherapy for cancer.

18 Dec 2021

Trial identifies a drug that may benefit some patients hospitalized with COVID-19 pneumonia

A proof-of-concept trial led by the Universities of Birmingham and University Hospitals Birmingham NHS Foundation Trust has identified a drug that may offer benefit some patients hospitalized with COVID-19 pneumonia.

18 Dec 2021

Study may lead to a paradigm shift in the care for adults who relapse from large B-cell lymphoma

A study published this month in the New England Journal of Medicine (NEJM) may change the standard of care for adults who relapse from large B-cell lymphoma.

17 Dec 2021

A class of FDA-approved drugs can effectively stop aggressive uterine cancer

A team of scientists led by the University of Michigan Health Rogel Cancer Center has found that a class of U.S. Food and Drug Administration-approved drugs can effectively stop a highly aggressive type of uterine cancer in its tracks, paving a quick path toward new treatment strategies for a deadly cancer with limited therapeutic options.

17 Dec 2021

Study determines minimally effective dose of clinical candidate gene therapy vector to treat hemophilia A

Researchers determined the minimally effective dose (MED) of a clinical candidate gene therapy vector for treating hemophilia A.

16 Dec 2021

ACTG announces the launch of clinical trial to evaluate new CMV vaccine in adults

The AIDS Clinical Trials Group (ACTG), the largest global HIV research network, today announced the launch of A5355, a clinical trial studying a new cytomegalovirus (CMV) vaccine in adults with both HIV and CMV.

16 Dec 2021

Scientists find better treatment options for patients with advanced colorectal cancer

City of Hope, a world-renowned cancer research and treatment organization, today announced study results of a Phase 2 clinical trial showing monotherapy with sotorasib resulted in anti-tumor activity and a favorable benefit-risk profile among heavily pretreated patients with advanced colorectal cancer. The research was published today in Lancet Oncology.

16 Dec 2021

New combined therapy shows promising results in treating triple negative breast cancer

A drug used to treat cardiac failure has shown promising results in treating triple negative breast cancer, according to Houston Methodist researchers who released results this week on a new combined therapy with the potential to improve outcomes for these hard-to-treat breast cancer patients.

15 Dec 2021

Clinical Trial News and Research

Protein-based nanoparticle vaccines for protection against SARS-CoV-2

UK government signs two new deals to combat the Omicron variant

Clinical trial results do not support the use of fish oil supplements to prevent depression

Doctors advised to prescribe fewer antidepressants and for shorter periods of time

Early administration of SARS-CoV-2 convalescent plasma reduces outpatient hospitalizations

Moving more often is beneficial for long-term weight maintenance in older adults

Clinical trial shows preliminary efficacy of all-oral regimen for patients with lenalidomide-refractory multiple myeloma

Study focuses on inherited Alzheimer’s up to 25 years before expected dementia onset

SGLT2 inhibitor empagliflozin can be used to treat insulin resistance in the brain, finds study

Researchers find a digital silver lining in failed COVID-19 drug trial

Efficacy of SARS-CoV2 variant-specific replicating RNA vaccines on SARS-CoV-2 variants of concern

Study examines the effects of methylphenidate on mental fatigue in multiple sclerosis patients

Scientists develop new immunotherapy for cancer based on transplant rejection mechanism

Trial identifies a drug that may benefit some patients hospitalized with COVID-19 pneumonia

Study may lead to a paradigm shift in the care for adults who relapse from large B-cell lymphoma

A class of FDA-approved drugs can effectively stop aggressive uterine cancer

Study determines minimally effective dose of clinical candidate gene therapy vector to treat hemophilia A

ACTG announces the launch of clinical trial to evaluate new CMV vaccine in adults

Scientists find better treatment options for patients with advanced colorectal cancer

New combined therapy shows promising results in treating triple negative breast cancer

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