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First rat model recapitulates all disabling alterations experienced by patients with Morquio A disease

A research team from the Universitat Autònoma de Barcelona has generated the first rat model recapitulating all disabling alterations experienced by patients with Mucopolysaccharidosis type IVA, also known as Morquio A disease.

12 Sep 2021

Washington University School of Medicine receives $7 million to investigate how human genome works

Washington University School of Medicine in St. Louis has received a $7 million grant from the National Institutes of Health to help lead national efforts to investigate how variations in the human genome sequence affect how the genome functions.

9 Sep 2021

UC San Diego researchers receive $6 million NIH grant to study insulin-producing cells

Sequencing the human genome - a feat accomplished in 2003 - provided the list of ingredients that make up a human being, but not the instructions that explain how those ingredients are used by each cell type to create complex "meals."

9 Sep 2021

Cellular program could turn T cells into effective cancer killers

Cancer-fighting immune cells in patients with lung cancer whose tumors do not respond to immunotherapies appear to be running on a different "program" that makes them less effective than immune cells in patients whose cancers respond to these immune treatments, suggests a new study led by researchers at the Johns Hopkins Kimmel Cancer Center Bloomberg~Kimmel Institute for Cancer Immunotherapy.

9 Sep 2021

IGVF consortium receives NIH funding to study how genomic variation influences biological function

The National Institutes of Health is providing approximately $185 million over five years to the Impact of Genomic Variation on Function consortium, initiated and funded by NIH's National Human Genome Research Institute.

9 Sep 2021

Are bat retroviruses a threat to humans?

Zoonotic viruses that bats transmit are capable of infecting humans and have caused devastating infections throughout the world.

9 Sep 2021

New vaccinia-based COVID-19 vaccine candidate induces robust, durable immune responses

Researchers in Australia have developed a coronavirus disease 2019 (COVID-9) vaccine that induced robust and long-lived humoral and cellular immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in both young and aging mice.

8 Sep 2021

Self-correcting genetic mutations may protect patients with shortened telomeres from blood cancers

People with rare disorders that cause shortened telomeres — protective caps that sit at the end of chromosomes — may be more likely to have blood cancers such as leukemia or myelodyplastic syndrome.

8 Sep 2021

Researchers receive $12.8M renewal grant to reveal how smoking causes distinct lung diseases

Despite cigarette smoking being the single most preventable risk factor for both chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF), two devastating diseases that make it hard to breathe, about 44 million American adults continue to smoke.

8 Sep 2021

Understanding how pathogens evolve novel virulence activities

Understanding how pathogens evolve is a fundamental component of learning how to protect ourselves and our world from pests and diseases.

7 Sep 2021

Cancer immunotherapies could benefit older patients as much as younger people

A retrospective analysis of large datasets of biomarkers from tumors and healthy tissue by researchers at the Johns Hopkins Kimmel Cancer Center Convergence Institute suggests that older cancer patients could benefit as much as younger patients from cancer immunotherapies.

7 Sep 2021

Research reveals a previously unknown role for a key transcription regulator linked to cancer

CTCF is a transcription factor that has been a research target due to its role in regulating a critical oncogene called MYC.

7 Sep 2021

Novel assay helps identify factors that can convert normal cells into liver cancer cells

Researchers at the University of Helsinki could show for the first time that normal human fibroblast cells can be converted to specific cancer cells using only factors that are commonly detected in actual human patients.

7 Sep 2021

Implications of persistent SARS-CoV-2 infection in patients with lymphoid malignancies

In a recent study, scientists attempt to understand persistent COVID-19 and its implications in patients with hematologic malignancies.

6 Sep 2021

New insights could help unlock the mystery of how lung cancer arises in never smokers

A genomic analysis of lung cancer in people with no history of smoking has found that a majority of these tumors arise from the accumulation of mutations caused by natural processes in the body.

6 Sep 2021

Patients who contract SARS-CoV-2 Delta variant more likely to be hospitalized than those with Alpha

Recently, researchers found the risk of being hospitalized was two times higher for people with the Delta variant as compared to those with the Alpha variant.

6 Sep 2021

Mystery deaths of children blamed on insanitary conditions and poor resources in India

While authorities in Uttar Pradesh are narrowing down on dengue as the 'mystery disease' behind the deaths of more than 50 people, mostly children, in the last fortnight, they are not ruling out scrub typhus or other monsoon-related infections.

6 Sep 2021

Delta variant has a more diverse repertoire of mutations than other variants

In a paper, nearly 2 million SARS-CoV-2 genomes from around the world were analyzed, finding great diversity within the delta variant that exceeds that observed in the more widely spread alpha variant.

6 Sep 2021

Characterization of SARS-CoV-2 viral trajectory

In a study available on the preprint server medRxiv* researchers aimed to characterize early viral shedding in patients with incident infection. Read more here.

6 Sep 2021

Researchers develop the smallest CRISPR to date for genome editing

A compact and efficient CRISPR-Cas system, named CasMINI, could be broadly useful for cell-engineering and gene-therapy applications because it is easier to deliver into cells. The findings appear in a study publishing September 3 in the journal Molecular Cell.

4 Sep 2021

Genome News and Research

First rat model recapitulates all disabling alterations experienced by patients with Morquio A disease

Washington University School of Medicine receives $7 million to investigate how human genome works

UC San Diego researchers receive $6 million NIH grant to study insulin-producing cells

Cellular program could turn T cells into effective cancer killers

IGVF consortium receives NIH funding to study how genomic variation influences biological function

Are bat retroviruses a threat to humans?

New vaccinia-based COVID-19 vaccine candidate induces robust, durable immune responses

Self-correcting genetic mutations may protect patients with shortened telomeres from blood cancers

Researchers receive $12.8M renewal grant to reveal how smoking causes distinct lung diseases

Understanding how pathogens evolve novel virulence activities

Cancer immunotherapies could benefit older patients as much as younger people

Research reveals a previously unknown role for a key transcription regulator linked to cancer

Novel assay helps identify factors that can convert normal cells into liver cancer cells

Implications of persistent SARS-CoV-2 infection in patients with lymphoid malignancies

New insights could help unlock the mystery of how lung cancer arises in never smokers

Patients who contract SARS-CoV-2 Delta variant more likely to be hospitalized than those with Alpha

Mystery deaths of children blamed on insanitary conditions and poor resources in India

Delta variant has a more diverse repertoire of mutations than other variants

Characterization of SARS-CoV-2 viral trajectory

Researchers develop the smallest CRISPR to date for genome editing

The art of CRISPR: The power and promise of gene editing eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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