Immune Response News and Research

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Novel platform uses modified virus to combat pancreatic cancer

Researchers from Queen Mary University of London and Zhengzhou University have developed a powerful therapeutic platform that uses a modified virus for the treatment of pancreatic cancer.

26 Jan 2021

Study shows how gut bacteria can dull the efficacy of radiotherapy

A study led by Ludwig Chicago Co-director Ralph Weichselbaum and Yang-Xin Fu of the University of Texas Southwestern Medical Center has shown how bacteria in the gut can dull the efficacy of radiotherapy, a treatment received by about half of all cancer patients.

26 Jan 2021

Moderna vaccine fully neutralizes new SARS-CoV-2 variants, study shows

Researchers in the United States have conducted a study showing that Moderna’s mRNA-1273 vaccine neutralizes all circulating variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) tested to date.

26 Jan 2021

Single-dose universal vaccine could protect against leptospirosis bacteria

Scientists have designed a single-dose universal vaccine that could protect against the many forms of leptospirosis bacteria, according to a study published today in eLife.

26 Jan 2021

Why even presidential pressure might not get more vaccine to market faster

Americans are dying of covid-19 by the thousands, but efforts to ramp up production of potentially lifesaving vaccines are hitting a brick wall.

26 Jan 2021

Researchers find microbiome-controlled anti-inflammatory subsets of astrocytes

Astrocytes are the most abundant type of cells within the central nervous system (CNS), but they remain poorly characterized.

26 Jan 2021

New SARS-CoV-2 variant must be curbed to protect UK health services, warn experts

A new research project called REACT-1 – launched by researchers at the Imperial College London, Imperial College Healthcare NHS Trust, and Ipsos MORI – has aimed to better understand the dynamics of SARS-CoV-2’s viral spread across the UK.

26 Jan 2021

Recombinant SARS-CoV-2 protein vaccine less immunogenic but more antigenic than expected

Now, a new preprint research paper posted to the medRxiv server presents preliminary results of a stabilized SARS-CoV-2 pre-fusion spike protein vaccine expressed in a baculovirus system (CoV2 preS dTM), with two different adjuvant formulations.

26 Jan 2021

Missing surface protein allows small cell lung cancer cells to hide from immune defenses

Small cell lung cancer (SCLC) cells are missing a surface protein that triggers an immune response, allowing them to hide from one of the body's key cancer defenses, a new study led by UT Southwestern researchers suggests.

25 Jan 2021

Combining anti-tumor antibodies with standard-of-care improves therapeutic outcomes in cancer

The cover for issue 2 of Oncotarget features Figure 4, "Combination therapy TA99/ICB reduced the lung tumor burden in the B16 model of metastases," published in "Improved therapeutic efficacy of unmodified anti-tumor antibodies by immune checkpoint blockade and kinase targeted therapy in mouse models of melanoma" by Pérez-Lorenzo, et al. which reported that here, the authors showed that removing immune suppression and enhancing stimulatory signals increased the anti-tumor activity of unmodified TA99 antibodies with a significant reduction of growth of solid tumors and lung metastases in mouse models of melanoma.

25 Jan 2021

Experts advise disaggregating data on COVID-19 patients by sex

Researchers at Yale University School of Medicine have highlighted the importance of ensuring studies of patients with coronavirus disease 2019 (COVID-19) report data in a sex-disaggregated manner.

24 Jan 2021

Study examines risk factors for developing ME/CFS in college students after infectious mononucleosis

Many college students fully recover from infectious mononucleosis (which is almost always caused by Epstein-Barr virus) within 1-6 weeks, but some go on to develop chronic fatigue syndrome, also called myalgic encephalomyelitis (ME/CFS).

22 Jan 2021

Researchers identify protein that may represent a safer treatment target for pancreatic cancer

Researchers from Queen Mary University of London, have identified a protein that may represent a novel therapeutic target for the treatment of pancreatic cancer.

22 Jan 2021

NSAIDs dampen antibody and inflammatory responses to SARS-CoV-2 infection in mice

New research shows that non-steroidal anti-inflammatory drugs (NSAIDs) reduced both antibody and inflammatory responses to SARS-CoV-2 infection in mice. The study appears this week in the Journal of Virology, a publication of the American Society for Microbiology.

22 Jan 2021

SARS-CoV-2’s nonstructural proteins dysregulate immune responses, study finds

Researchers provide an overview of SARS-CoV-2 and its life cycle pathways, addressing the functional changes in the viral proteins, providing important strategic clues to help that may help in the ongoing development of therapies against COVID-19.

22 Jan 2021

A traditional Chinese medicine could help treat COVID‐19 symptoms

A team of researchers in China – at Guangzhou University of Chinese Medicine and Yunnan University of Chinese Medicine – recently explored the therapeutic properties of Yinqiao powder in treating COVID-19 symptoms. Their findings were recently published in Phytotherapy Research.

22 Jan 2021

Study reveals new insights into how UV light triggers kidney inflammation in lupus patients

A new collaborative study from researchers at the Geisel School of Medicine at Dartmouth and the University of Washington (UW) and published in the Proceedings of the National Academy of Sciences, reveals unexpected insights into how skin exposure to ultraviolet light can worsen clinical symptoms in autoimmune diseases such as lupus.

22 Jan 2021

Researchers develop comprehensive framework to classify small-cell lung cancer

Researchers from The University of Texas MD Anderson Cancer Center have developed the first comprehensive framework to classify small-cell lung cancer (SCLC) into four unique subtypes, based on gene expression, and have identified potential therapeutic targets for each type in a study published today in Cancer Cell.

22 Jan 2021

Researchers identify genetic risk factors contributing to pneumonia susceptibility and severity

Researchers at Vanderbilt University Medical Center and colleagues have identified genetic factors that increase the risk for developing pneumonia and its severe, life-threatening consequences.

21 Jan 2021

Scientists identify a molecular mechanism that protects the fetus from maternal infection

Researchers at Duke and Mt. Sinai have identified a molecular mechanism that prevents a viral infection during a mother's pregnancy from harming her unborn baby.

21 Jan 2021

Immune Response News and Research

Novel platform uses modified virus to combat pancreatic cancer

Study shows how gut bacteria can dull the efficacy of radiotherapy

Moderna vaccine fully neutralizes new SARS-CoV-2 variants, study shows

Single-dose universal vaccine could protect against leptospirosis bacteria

Why even presidential pressure might not get more vaccine to market faster

Researchers find microbiome-controlled anti-inflammatory subsets of astrocytes

New SARS-CoV-2 variant must be curbed to protect UK health services, warn experts

Recombinant SARS-CoV-2 protein vaccine less immunogenic but more antigenic than expected

Missing surface protein allows small cell lung cancer cells to hide from immune defenses

Combining anti-tumor antibodies with standard-of-care improves therapeutic outcomes in cancer

Experts advise disaggregating data on COVID-19 patients by sex

Study examines risk factors for developing ME/CFS in college students after infectious mononucleosis

Researchers identify protein that may represent a safer treatment target for pancreatic cancer

NSAIDs dampen antibody and inflammatory responses to SARS-CoV-2 infection in mice

SARS-CoV-2’s nonstructural proteins dysregulate immune responses, study finds

A traditional Chinese medicine could help treat COVID‐19 symptoms

Study reveals new insights into how UV light triggers kidney inflammation in lupus patients

Researchers develop comprehensive framework to classify small-cell lung cancer

Researchers identify genetic risk factors contributing to pneumonia susceptibility and severity

Scientists identify a molecular mechanism that protects the fetus from maternal infection

Understanding the DNA Damage Response in Innate Immunity eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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