Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

UR researchers on track to solve mystery of weight gain

University of Rochester researchers believe they're on track to solve the mystery of weight gain - and it has nothing to do with indulging in holiday eggnog.

12 Dec 2014

OPTIMISE project to collect data that provides in-depth picture of MS experiences

Researchers will track the lives of people with multiple sclerosis (MS) in unprecedented detail in a project to improve the evaluation of treatments.

11 Dec 2014

Andor's Komet software used to automatically score modified 3D 'Comet' assay results

With cancer rates rising worldwide, and Cancer Research UK predicting that the lifetime risk of cancer will reach 50% by 2027, the need for early diagnosis is overwhelming. Now, a British research group has published details of a simple empirical test to detect any early-stage cancer, relying on Andor's Komet software to automatically score the modified 3D 'Comet' assay results.

From Andor Technology Ltd. 11 Dec 2014

New study reveals how COX-2 inhibitors can increase risk of heart attack in arthritis patients

A class of drug for treating arthritis - all but shelved over fears about side effects - may be given a new lease of life, following the discovery of a possible way to identify which patients should avoid using it.

11 Dec 2014

UTHealth opens Trauma and Grief Center for Youth

Children who are having difficulty processing trauma or loss can now turn to the Trauma and Grief Center for Youth at The University of Texas Health Science Center at Houston.

10 Dec 2014

Simple blood test could help to detect breast cancer early

It may be possible to develop a simple blood test that, by detecting changes in the zinc in our bodies, could help to diagnose breast cancer early.

9 Dec 2014

BAZ2A protein directly influences the aggressiveness of prostate cancer

A protein that influences the epigenetic characteristics of tumor cells is directly linked to the grade of malignancy of prostate cancer. This key discovery has been made by a team of scientists from the German Cancer Research Center, the University of Zurich, Hamburg-Eppendorf University Hospital, Heidelberg University, and other institutes in a study of 7,700 samples of tumor tissue.

9 Dec 2014

Novel treatments show promising results in patients with different hematologic disorders

In recent years, a number of scientific breakthroughs have led to the development of drugs that unleash the power of the immune system to recognize and attack cancer. Studies presented today at the 56th Annual Meeting of the American Society of Hematology highlight the enormous potential these novel treatments have for patients with a variety of hematologic disorders.

7 Dec 2014

Novel treatments show safe responses in patients with relapsed, treatment-resistant blood cancers

Novel treatments that harness the body's own immune cells to attack cancer cells demonstrate safe and durable responses in patients with relapsed and treatment-resistant blood cancers, according to data presented today at the 56th American Society of Hematology Annual Meeting and Exposition.

7 Dec 2014

Two medical imaging techniques could predict effectiveness of TB drugs

Two medical imaging techniques, called positron emission tomography (PET) and computed tomography (CT), could be used in combination as a biomarker to predict the effectiveness of antibiotic drug regimens being tested to treat tuberculosis (TB) patients, according to researchers at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.

5 Dec 2014

Landmark CoMMpass Study data now available through MMRF Researcher Gateway

The Multiple Myeloma Research Foundation announced today that new data from the landmark CoMMpass Study is now available to researchers via the MMRF's Researcher Gateway, an online, open-access portal designed to make key genomic and clinical data publically available for additional study.

5 Dec 2014

BeyondSpring Pharmaceuticals plans to initiate Plinabulin Phase 3 pivotal trial in NSCLC patients

BeyondSpring Pharmaceuticals, Inc., a clinical stage biopharmaceutical company focused on the development of innovative cancer therapies, today announced that it plans to initiate a Phase 3 pivotal trial of lead product candidate, Plinabulin, in patients with non-small cell lung cancer (NSCLC) in the first quarter of 2015.

4 Dec 2014

Ceres to develop new method for detecting the presence of Ebola virus in saliva

Ceres Nanosciences Inc. today announced the commencement of a development program, funded by the Gates Foundation, to use Ceres' Nanotrap particle technology to develop a new method of detecting the presence of the Ebola virus in saliva.

3 Dec 2014

Neuroimaging markers have synergistic effect on cognitive decline

The Alzheimer disease neuroimaging markers β-amyloid and neurodegeneration have synergistic effects on the rate of cognitive decline in clinically normal people, research shows.

2 Dec 2014

Real-time surgical guidance study to evaluate TriVersa NanoMate with LESA capability from Advion

Advion, Inc. announces that is its TriVersa NanoMate with liquid extraction surface analysis (LESA) capability will be evaluated as part of a study at Brigham and Women’s Hospital.

From Advion 2 Dec 2014

Researchers identify possible prognostic biomarker in triple-negative breast cancer

"Triple-negative" breast cancer (TNBC) occurs in patients whose cells do not express receptors for estrogen, progesterone, and/or human epidermal growth factor receptor 2 (ER-/PR-/HER2-).

2 Dec 2014

Researchers identify new genetic biomarkers that predict outcomes for patients with bowel cancer

Researchers at University of Limerick and University Hospital Limerick have identified several new genetic biomarkers which better predict outcomes for patients with bowel/colorectal cancer. The research team identified genes that are predictors of cancer recurrence and can also help to identify a patients’ suitability to specific types of chemotherapy.

1 Dec 2014

DTI may play role in assessing brain damage in early Alzheimer's disease

Changes in brain connections visible on MRI could represent an imaging biomarker of Alzheimer's disease, according to a new study presented today at the annual meeting of the Radiological Society of North America (RSNA).

1 Dec 2014

Experimental drug works best when patients' immune cells surrounding tumors express PD-L1

A promising experimental immunotherapy drug works best in patients whose immune defenses initially rally to attack the cancer but then are stymied by a molecular brake that shuts down the response, according to a new study led by researchers at Dana-Farber Cancer Institute and the Yale University School of Medicine.

28 Nov 2014

TET1 enzyme may be important target for cancer diagnostics, treatment

Mutations in the KRAS gene have long been known to cause cancer, and about one third of solid tumors have KRAS mutations or mutations in the KRAS pathway. KRAS promotes cancer formation not only by driving cell growth and division, but also by turning off protective tumor suppressor genes, which normally limit uncontrolled cell growth and cause damaged cells to self-destruct.

27 Nov 2014

Biomarker News and Research

Further Reading

UR researchers on track to solve mystery of weight gain

OPTIMISE project to collect data that provides in-depth picture of MS experiences

Andor's Komet software used to automatically score modified 3D 'Comet' assay results

New study reveals how COX-2 inhibitors can increase risk of heart attack in arthritis patients

UTHealth opens Trauma and Grief Center for Youth

Simple blood test could help to detect breast cancer early

BAZ2A protein directly influences the aggressiveness of prostate cancer

Novel treatments show promising results in patients with different hematologic disorders

Novel treatments show safe responses in patients with relapsed, treatment-resistant blood cancers

Two medical imaging techniques could predict effectiveness of TB drugs

Landmark CoMMpass Study data now available through MMRF Researcher Gateway

BeyondSpring Pharmaceuticals plans to initiate Plinabulin Phase 3 pivotal trial in NSCLC patients

Ceres to develop new method for detecting the presence of Ebola virus in saliva

Neuroimaging markers have synergistic effect on cognitive decline

Real-time surgical guidance study to evaluate TriVersa NanoMate with LESA capability from Advion

Researchers identify possible prognostic biomarker in triple-negative breast cancer

Researchers identify new genetic biomarkers that predict outcomes for patients with bowel cancer

DTI may play role in assessing brain damage in early Alzheimer's disease

Experimental drug works best when patients' immune cells surrounding tumors express PD-L1

TET1 enzyme may be important target for cancer diagnostics, treatment

Event guide: 15th World Clinical Biomarkers & CDx Europe eBook

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