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What is the prevalence of contraindications to Paxlovid among hospitalized COVID-19 patients?

Researchers examined the prevalence of contraindications to nirmatrelvir-ritonavir (Paxlovid) in hospitalized coronavirus disease 2019 (COVID-19) patients.

17 Nov 2022

Researchers identify a conserved site on SARS-CoV-2 spike that a broadly neutralizing macrocyclic peptide can target

Researchers explored the efficiency of a macrocyclic peptide in inhibiting the SARS-CoV-2 spike protein.

17 Nov 2022

When is it best to use dose-sparing vaccination strategies for monkeypox to protect more people?

Researchers evaluated dose-sparing strategies for monkeypox (MPX) vaccination using mathematical modeling.

17 Nov 2022

Augmented drug preferentially eliminates cancer cells but does not harm healthy cells

Johns Hopkins Medicine researchers have revamped an anti-cancer drug to better target cancer cells and leave healthy tissues unharmed. Scientists have dubbed this type of targeted approach a "prodrug" - a medicine designed to release its payload in a particular area of the body and in no other areas.

17 Nov 2022

Study finds a lower compliance rate with recently released guidelines for COVID-19 care

Uptake of national guidelines for the treatment of children hospitalized with COVID-19 fell well below what would typically be expected, report researchers at the Medical University of South Carolina (MUSC) and elsewhere in Pediatrics.

17 Nov 2022

SARS-CoV-2 ‘Deltacron’ variant exhibits immune-escape properties similar to Omicron BA.1

The SARS-CoV-2 Deltacron does not exhibit higher transmissibility or immune evasion than the Omicron BA.1 variant.

16 Nov 2022

Machine learning algorithm predicts a tumor’s response to immune checkpoint blockade

Predicting which patients will respond well to treatment is a quandary that has plagued the field of cancer immunotherapy for more than four decades.

16 Nov 2022

COVID-19 mRNA boosters induce robust but non-durable immune response in the elderly

A study published in the journal Frontiers in Immunology describes that the third booster dose of coronavirus disease 2019 (COVID-19) effectively induces an immune response against immunologically more fit variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the immunity induced by the booster vaccination is transient and gradually declines over time.

15 Nov 2022

Development of a potent, broadly protective vaccine against all SARS-CoV-2 variants

In a recent study published in the journal npj Vaccines, researchers in China designed, produced, and evaluated the neutralization efficacy of a recombinant coronavirus disease 2019 (COVID-19) vaccine containing four hot-spot substitution mutations based on a prefusion-stabilized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein (S) trimer.

15 Nov 2022

Black, Hispanic MSM disproportionately affected by monkeypox

A recent study published in the Morbidity and Mortality Weekly Report described the epidemiologic characteristics of the monkeypox (MPX) outbreak in the United States (US).

15 Nov 2022

New drug could be a game changer for cancer patients undergoing chemotherapy

Cisplatin is a chemotherapy indicated to fight tumors in many types of cancer. However, it does have major side effects – especially kidney toxicity, that can lead to acute kidney failure.

15 Nov 2022

Polyphenols in Mediterranean diet may modulate COVID-19 inflammation

Researchers discuss the beneficial role of polyphenolic plant compounds in the Mediterranean diet in the prevention and treatment of COVID-19.

15 Nov 2022

What are the current challenges and future directions of mRNA nanomedicine?

Researchers presented challenges related to the clinical translation of messenger ribonucleic acid (mRNA) technology, recent innovations and future directions to improve the clinical efficacy of mRNA nanomedicine.

15 Nov 2022

Certain TB correlates of protection linked with the likelihood of becoming infected with Mycobacterium tuberculosis

Researchers from the University of Oxford have today reported findings from a study that investigated whether previously identified correlates of protection associated with risk of full-blown tuberculosis (TB) disease could also be associated with risk of infection from the bacteria that causes TB.

15 Nov 2022

Short-term outcomes in pregnant patients with COVID-19 who received nirmatrelvir–ritonavir treatment

Researchers investigated the short-term outcomes of treating pregnant patients exhibiting mild to moderate symptoms of COVID-19 with Paxlovid, which is a combination of the antivirals nirmatrelvir and ritonavir.

15 Nov 2022

Patients complain some obesity care startups offer pills, and not much else

Many Americans turn to the latest big idea to lose weight — fad diets, fitness crazes, dodgy herbs and pills, bariatric surgery, just to name a few. They're rarely the magic solution people dream of.

15 Nov 2022

Moderna's bivalent boosters trigger strong antibody response against latest subvariants

Moderna reports the efficacy of a bivalent COVID-19 vaccine booster dose.

14 Nov 2022

A novel mRNA-based vaccine candidate against the rabies virus

Scientists have developed a novel mRNA-based vaccine candidate against the rabies virus. The vaccine induces a strong antibody response and exhibits high protective efficacy against lethal rabies infection in mice and dogs. A full report about the vaccine has been published in the Virology Journal.

14 Nov 2022

New fentanyl vaccine could prevent deadly opioid from entering the brain

A research team led by the University of Houston has developed a vaccine targeting the dangerous synthetic opioid fentanyl that could block its ability to enter the brain, thus eliminating the drug's "high."

14 Nov 2022

Mechanically active adhesive prevents and supports the recovery from muscle atrophy

Muscles waste as a result of not being exercised enough, as happens quickly with a broken limb that has been immobilized in a cast, and more slowly in people reaching an advanced age.

14 Nov 2022

Efficacy News and Research

What is the prevalence of contraindications to Paxlovid among hospitalized COVID-19 patients?

Researchers identify a conserved site on SARS-CoV-2 spike that a broadly neutralizing macrocyclic peptide can target

When is it best to use dose-sparing vaccination strategies for monkeypox to protect more people?

Augmented drug preferentially eliminates cancer cells but does not harm healthy cells

Study finds a lower compliance rate with recently released guidelines for COVID-19 care

SARS-CoV-2 ‘Deltacron’ variant exhibits immune-escape properties similar to Omicron BA.1

Machine learning algorithm predicts a tumor’s response to immune checkpoint blockade

COVID-19 mRNA boosters induce robust but non-durable immune response in the elderly

Development of a potent, broadly protective vaccine against all SARS-CoV-2 variants

Black, Hispanic MSM disproportionately affected by monkeypox

New drug could be a game changer for cancer patients undergoing chemotherapy

Polyphenols in Mediterranean diet may modulate COVID-19 inflammation

What are the current challenges and future directions of mRNA nanomedicine?

Certain TB correlates of protection linked with the likelihood of becoming infected with Mycobacterium tuberculosis

Short-term outcomes in pregnant patients with COVID-19 who received nirmatrelvir–ritonavir treatment

Patients complain some obesity care startups offer pills, and not much else

Moderna's bivalent boosters trigger strong antibody response against latest subvariants

A novel mRNA-based vaccine candidate against the rabies virus

New fentanyl vaccine could prevent deadly opioid from entering the brain

Mechanically active adhesive prevents and supports the recovery from muscle atrophy

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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