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Research reveals vital role of protein-coding gene in tumor development and immune therapy response

Researchers from the Case Comprehensive Cancer Center uncovered the potentially important role of the protein-coding gene, MYO10, in tumor development and immune therapy response. Their findings were published today in Science Advances.

16 Sep 2021

Evolved SARS-CoV-2 viruses gain higher infectivity and cause more rapid infection spread

Viruses accumulate mutations as they replicate in infected cells. Repeated replication can lead to viral strains that show attenuated virulence. Such strains may act as vaccines if the attenuated virus can produce immunity without serious disease.

16 Sep 2021

This 3D modeling reveals how SARS-CoV-2 attacks

Now, researchers at the Garvan Institute of Medical Research, Darlinghurst in Australia, CSIRO Data61, and the School of Biotechnology and Biomolecular Sciences (UNSW) demonstrated the most comprehensive analysis of the three-dimensional structure of SARS-CoV-2, providing a new insight into how the virus infects cells and replicates.

16 Sep 2021

Study reveals role of globalization and zoonosis in the emergence and spread of SARS-CoV-2 variants

A recent study aimed to use their own classification of different SARS-CoV-2 lineages that would help monitor their genetic features and geographical origins.

14 Sep 2021

Gut microbiome profile could help predict patient's rheumatoid arthritis prognosis

A significant indicator of whether a patient with rheumatoid arthritis will improve over the course of disease may lie in part in their gut, according to new research from Mayo Clinic's Center for Individualized Medicine.

14 Sep 2021

Jumpcode Genomics and TGen collaborate on genomic sequencing of SARS-CoV-2

Jumpcode Genomics, a genome technology platform company focused on improving the understanding of human biology, announced today a collaboration with the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, to aid investigations into the genomic epidemiology of SARS-CoV-2, the virus that causes COVID-19.

14 Sep 2021

GIST researchers unravel coordination mechanism of base excision repair

A new study by researchers from the Gwangju Institute of Science and Technology in the Republic of Korea has revealed the mechanism of DNA repair by enzymes exonuclease III and polymerase I by utilizing single molecule fluorescence resonance energy transfer (smFRET)-enabled dynamic observation.

14 Sep 2021

Dynamics of healthcare-associated SARS-CoV-2 infections revealed with whole genome sequencing

In a recent paper, the researchers study the dynamics of SARS-CoV-2 infections on a geriatric hospital ward by whole genome sequencing.

13 Sep 2021

New SARS-CoV-2 mechanism of host gene suppression

A new study finds that the viral non-coding RNA dubbed vmiR-5p, derived from the viral gene ORF7a, appears to reduce host transcription.

13 Sep 2021

Analysis finds untapped potential for immunotherapy in older cancer patients

A retrospective analysis of large datasets of biomarkers from tumors and healthy tissue by researchers at the Johns Hopkins Kimmel Cancer Center Convergence Institute suggests that older cancer patients could benefit as much as younger patients from cancer immunotherapies.

13 Sep 2021

SARS-CoV-2 may have consequences to host cells beyond evoking an immune response

A recent study examined the ability of SARS-CoV-2 to impact DNA damage response and telomere stability in Vero E6 cells.

13 Sep 2021

Lessons from COVID-19 response during first three waves in New South Wales

Scientists from Australia have recently analyzed the public health measures adopted by the authorities during the three waves of coronavirus disease 2019 (COVID-19) pandemic in New South Wales, Australia.

12 Sep 2021

Researchers discover transposon-encoded RNA-guided nucleases with potential for genome editing

Researchers seeking to understand the origins of CRISPR-Cas9 systems have uncovered a class of transposon-encoded RNA-guided nucleases, which they dubbed "OMEGA," that could be harnessed for genome editing in human cells.

12 Sep 2021

First rat model recapitulates all disabling alterations experienced by patients with Morquio A disease

A research team from the Universitat Autònoma de Barcelona has generated the first rat model recapitulating all disabling alterations experienced by patients with Mucopolysaccharidosis type IVA, also known as Morquio A disease.

12 Sep 2021

Washington University School of Medicine receives $7 million to investigate how human genome works

Washington University School of Medicine in St. Louis has received a $7 million grant from the National Institutes of Health to help lead national efforts to investigate how variations in the human genome sequence affect how the genome functions.

9 Sep 2021

UC San Diego researchers receive $6 million NIH grant to study insulin-producing cells

Sequencing the human genome - a feat accomplished in 2003 - provided the list of ingredients that make up a human being, but not the instructions that explain how those ingredients are used by each cell type to create complex "meals."

9 Sep 2021

Cellular program could turn T cells into effective cancer killers

Cancer-fighting immune cells in patients with lung cancer whose tumors do not respond to immunotherapies appear to be running on a different "program" that makes them less effective than immune cells in patients whose cancers respond to these immune treatments, suggests a new study led by researchers at the Johns Hopkins Kimmel Cancer Center Bloomberg~Kimmel Institute for Cancer Immunotherapy.

9 Sep 2021

IGVF consortium receives NIH funding to study how genomic variation influences biological function

The National Institutes of Health is providing approximately $185 million over five years to the Impact of Genomic Variation on Function consortium, initiated and funded by NIH's National Human Genome Research Institute.

9 Sep 2021

Are bat retroviruses a threat to humans?

Zoonotic viruses that bats transmit are capable of infecting humans and have caused devastating infections throughout the world.

9 Sep 2021

New vaccinia-based COVID-19 vaccine candidate induces robust, durable immune responses

Researchers in Australia have developed a coronavirus disease 2019 (COVID-9) vaccine that induced robust and long-lived humoral and cellular immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in both young and aging mice.

8 Sep 2021

Genome News and Research

Research reveals vital role of protein-coding gene in tumor development and immune therapy response

Evolved SARS-CoV-2 viruses gain higher infectivity and cause more rapid infection spread

This 3D modeling reveals how SARS-CoV-2 attacks

Study reveals role of globalization and zoonosis in the emergence and spread of SARS-CoV-2 variants

Gut microbiome profile could help predict patient's rheumatoid arthritis prognosis

Jumpcode Genomics and TGen collaborate on genomic sequencing of SARS-CoV-2

GIST researchers unravel coordination mechanism of base excision repair

Dynamics of healthcare-associated SARS-CoV-2 infections revealed with whole genome sequencing

New SARS-CoV-2 mechanism of host gene suppression

Analysis finds untapped potential for immunotherapy in older cancer patients

SARS-CoV-2 may have consequences to host cells beyond evoking an immune response

Lessons from COVID-19 response during first three waves in New South Wales

Researchers discover transposon-encoded RNA-guided nucleases with potential for genome editing

First rat model recapitulates all disabling alterations experienced by patients with Morquio A disease

Washington University School of Medicine receives $7 million to investigate how human genome works

UC San Diego researchers receive $6 million NIH grant to study insulin-producing cells

Cellular program could turn T cells into effective cancer killers

IGVF consortium receives NIH funding to study how genomic variation influences biological function

Are bat retroviruses a threat to humans?

New vaccinia-based COVID-19 vaccine candidate induces robust, durable immune responses

The art of CRISPR: The power and promise of gene editing eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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