Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Changes in cell metabolism slow growth of colorectal cancer

Cancer is an unwanted experiment in progress. As the disease advances, tumor cells accumulate mutations, eventually arriving at ones that give them the insidious power to grow uncontrollably and spread. Distinguishing drivers of cancer from benign mutations open opportunities for developing targeted cancer therapies.

30 Oct 2014

TNF-α key player in RCC progression

Tumour necrosis factor - α appears to play a key role in the promotion of invasion and metastasis in clear cell renal cell carcinomas, Japanese study findings indicate.

30 Oct 2014

Study on papillary thyroid carcinoma to be presented at 84th Annual Meeting of the ATA

The prevalence of papillary thyroid carcinoma (PTC), the most common type of thyroid cancer, is increasing rapidly. New research to determine the impact of radioactive iodine (RAI) therapy on survival in PTC, describing a novel blood test able to detect circulating BRAFV600E-positive tumor DNA, and identifying a long non-coding RNA specifically associated with the thyroid that is down-regulated in PTC compared to normal thyroid tissue in patient-derived clinical specimens and cell cultures will be featured in oral presentations delivered at the 84th Annual Meeting of the American Thyroid Association, October 29-November 2, 2014, in Coronado, California.

30 Oct 2014

New blood test could predict early onset Alzheimer’s disease with high accuracy

The research team previously identified that changes in the brain occur two decades before patients show signs of dementia. These changes can be detected through expensive brain imaging procedures.

30 Oct 2014

Myriad's Prolaris test included in NCCN Guidelines for men with localized prostate cancer

Myriad Genetics, Inc. today announced that its Prolaris test has been included in the National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology (NCCN Guidelines) for all men with localized prostate cancer, regardless of their risk category.

28 Oct 2014

RNF43 mutation may serve as biomarker that identifies colorectal, endometrial cancer patients

Scientists say they have identified in about 20 percent of colorectal and endometrial cancers a genetic mutation that had been overlooked in recent large, comprehensive gene searches. With this discovery, the altered gene, called RNF43, now ranks as one of the most common mutations in the two cancer types.

27 Oct 2014

Tiny nano-sized particles may play major role in detecting, tracking breast cancer

Exosomes, tiny, virus-sized particles released by cancer cells, can bioengineer micro-RNA (miRNA) molecules resulting in tumor growth. They do so with the help of proteins, such as one named Dicer. New research from The University of Texas MD Anderson Cancer Center suggests Dicer may also serve as a biomarker for breast cancer and possibly open up new avenues for diagnosis and treatment.

27 Oct 2014

Autism Speaks grants $1M to Children's Hospital Los Angeles to improve GI symptoms associated with ASD

Pat Levitt, PhD, Simms/Mann Chair in Developmental Neurogenetics at Children's Hospital Los Angeles, has received a grant of nearly $1 million from Autism Speaks, the world's leading autism science and advocacy organization.

24 Oct 2014

Aseptika selected for Discovery Start-Ups 2014 award

Aseptika Limited was selected as one of five winners out of the eighteen strong field of UK start-up companies pitching for the winning prizes at the Discovery Start-Ups 2014 event held on Wednesday, 22nd October at Deloitte’s in London.

24 Oct 2014

Novel 'designer' nanodevice could improve cancer diagnostics, treatment

Cancer diagnostics and treatment options could be drastically improved with the creation of a 'designer' nanodevice being developed by researchers from the UK, Italy, the US and Argentina.

22 Oct 2014

Biomarker test available for breast cancer, but remains unclear for patients with intermediate risk of recurrence

To make a decision for or against adjuvant chemotherapy, a test to measure the concentrations of the biomarkers uPA and PAI-1 in the tumour tissue is available for breast cancer patients.

21 Oct 2014

Researchers define the process of Parkinson's disease using genetic mouse model

Parkinson's Disease is the second most common neurodegenerative disorder. In Germany alone, almost half a million people are affected. The focus of the disease is the progressive degeneration of dopamine-producing nerve cells in a certain region of the midbrain, the substantia nigra. Misfolded proteins are the cause. Until recently, it was unclear why damage is confined to specific nerve cells.

16 Oct 2014

Intake of arsenic linked to cardiovascular disease, diabetes

Associated with various types of cancer such as skin and liver, the intake of arsenic it is also linked to cardiovascular disease and diabetes. According to a long-term research conducted by experts from the Center for Research and Advanced Studies it was determined that this metalloid inhibits enzymes associated with antioxidant protection.

16 Oct 2014

UL research unlocks major scientific challenge that has potential for rapid diagnostics tools

Research from the University of Limerick has unlocked a major scientific challenge which has exciting potential for point of care medical tests. The research entitled ‘Nanoelectrical analysis of single molecules and atomic-scale materials at the solid/liquid interface’ is reported online in Nature Materials.

15 Oct 2014

Research findings point toward new therapeutic target for aggressive breast cancer

One of the first-known oncogenes has a protein partner that helps breast cancer proliferate and when it's blocked, so is the cancer, scientists report.

15 Oct 2014

Obesity greatly accelerates aging of the liver

Using a recently developed biomarker of aging known as an epigenetic clock, UCLA researchers working closely with a German team of investigators have found for the first time that obesity greatly accelerates aging of the liver. This finding could explain the early onset of many age-related diseases, including liver cancer, in obese subjects

13 Oct 2014

Recent clinical study sheds light on potential approach to more personalized care for pancreatic cancer

Pancreatic cancer is one of the deadliest cancers. Even with aggressive treatment, the prognosis is poor, with various factors stacking the odds against successful treatment: early detection is uncommon, it tends to spread quickly and recurrence is likely. However, several newer approaches show promise in increasing the response rate to pancreatic cancer treatment.

10 Oct 2014

RNA molecules in tissue, urine samples can detect prostate cancer

Researchers at Sanford-Burnham Medical Research Institute have identified a set of RNA molecules that are detectable in tissue samples and urine of prostate cancer patients but not in normal healthy individuals.

10 Oct 2014

Scientists use novel way to identify new gene linked to Alzheimer's

Scientists at The University of Manchester have used a new way of working to identify a new gene linked to neurodegenerative diseases such as Alzheimer's. The discovery fills in another piece of the jigsaw when it comes to identifying people most at risk of developing the condition.

From The University of Manchester 10 Oct 2014

Astute Medical to get $30 million from CRG to support commercialization of NephroCheck Test System

Astute Medical, Inc. and CRG today announced that Astute recently achieved a milestone under the terms of its existing term loan agreement with CRG. Under the term loan agreement, CRG will provide up to $30 million to support the commercialization of the NephroCheck Test System.

9 Oct 2014

Biomarker News and Research

Further Reading

Changes in cell metabolism slow growth of colorectal cancer

TNF-α key player in RCC progression

Study on papillary thyroid carcinoma to be presented at 84th Annual Meeting of the ATA

New blood test could predict early onset Alzheimer’s disease with high accuracy

Myriad's Prolaris test included in NCCN Guidelines for men with localized prostate cancer

RNF43 mutation may serve as biomarker that identifies colorectal, endometrial cancer patients

Tiny nano-sized particles may play major role in detecting, tracking breast cancer

Autism Speaks grants $1M to Children's Hospital Los Angeles to improve GI symptoms associated with ASD

Aseptika selected for Discovery Start-Ups 2014 award

Novel 'designer' nanodevice could improve cancer diagnostics, treatment

Biomarker test available for breast cancer, but remains unclear for patients with intermediate risk of recurrence

Researchers define the process of Parkinson's disease using genetic mouse model

Intake of arsenic linked to cardiovascular disease, diabetes

UL research unlocks major scientific challenge that has potential for rapid diagnostics tools

Research findings point toward new therapeutic target for aggressive breast cancer

Obesity greatly accelerates aging of the liver

Recent clinical study sheds light on potential approach to more personalized care for pancreatic cancer

RNA molecules in tissue, urine samples can detect prostate cancer

Scientists use novel way to identify new gene linked to Alzheimer's

Astute Medical to get $30 million from CRG to support commercialization of NephroCheck Test System

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