Clinical Trial News and Research

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Mouthwash containing an antiviral phthalocyanine derivative shortens hospitalizations due to COVID-19

In a study published in the journal Scientific Reports, a research group from Brazil showed how antiviral anionic phthalocyanine derivative used in a mouthwash protocol may not only reduce the symptoms of coronavirus disease (COVID-19), but also hamper the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

23 Nov 2021

Anti-inflammatory drug used to treat gout does not reduce the risk of COVID-19 mortality

Colchicine, a cheap anti-inflammatory drug normally used to treat gout, doesn't lessen COVID-19 severity or stave off the risk of death from the infection in hospital patients, finds a pooled analysis of the available evidence, published in the open access journal RMD Open.

23 Nov 2021

Oral Hsp90 inhibitor SNX-5422 interferes with replication machinery of SARS-CoV-2

A new study evaluates the efficacy of SNX-5422 as a post-exposure prophylactic treatment.

23 Nov 2021

UW researchers develop a wearable device to detect and reverse opioid overdose

A research team at the University of Washington has developed a wearable device to detect and reverse an opioid overdose.

22 Nov 2021

‘Surgery selfies’ can help with early identification of infections

Smartphone pictures of post-surgical wounds taken by patients and then assessed by clinicians can help with the early identification of infections, a study has found.

20 Nov 2021

First long-acting injectable HIV treatment appraised and approved by NICE

ViiV Healthcare, the global specialist HIV company majority owned by GlaxoSmithKline plc, with Pfizer Inc. and Shionogi Limited as shareholders, is pleased to announce that eligible people living with Human Immunodeficiency Virus (HIV) in England and Wales will soon have routine access to Vocabria (cabotegravir long-acting injection) developed by ViiV Healthcare in combination with Rekambys (rilpivirine long-acting injection), developed by Janssen Sciences Ireland UC (Janssen), one of the Janssen Pharmaceutical Companies of Johnson & Johnson.

19 Nov 2021

A nasal COVID vaccine using a weakened influenza vector

The authors of a new study, published on the bioRxiv* preprint server, constructed a COVID-19 nasal vaccine candidate by inserting a gene encoding the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2, named CA4-dNS1-nCoV-RBD (dNS1-RBD) in a live attenuated influenza virus (LAIV) vector.

18 Nov 2021

Study involving a rat model offers potential treatment for Alexander disease

Alexander disease is a progressive and rare neurological disorder with no cure or standard course of treatment. But a new study led by researchers at the University of Wisconsin–Madison involving a rat model of the disease offers a potential treatment for the typically fatal condition.

18 Nov 2021

New test enables patient-specific monitoring and treatment for ovarian cancer

Around 870 cases of ovarian cancer are reported in Belgium every year. Most of these patients are treated with surgical interventions and/or chemotherapy.

18 Nov 2021

Researchers receive $22 million grant for clinical trial that aims to reduce lung transplant rejection

Physicians at Washington University School of Medicine in St. Louis and Massachusetts General Hospital/Harvard Medical School in Boston have received a seven-year, $22 million grant from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health to help lead a multicenter clinical trial evaluating whether a novel immunosuppressant can reduce the risk of organ rejection after a lung transplant.

18 Nov 2021

Short-term severe calorie restriction safe, feasible, and well tolerated by cancer patients

A diet involving short-term, severe calorie restriction was safe, feasible, and resulted in a decrease of blood glucose and growth factor concentration, reduction in peripheral blood immunosuppressive cells, and enhanced intratumor T-cell infiltration in cancer patients receiving standard-of-care therapy, according to the results of a clinical trial.

18 Nov 2021

Tighter blood pressure management may lead to better spinal cord injury recovery

Patients with new spinal cord injuries whose blood pressure is maintained within a newly defined range during surgery may stand a better chance of regaining some mobility and functionality – even in patients with the most devastating injuries – according to a new study by researchers at UC San Francisco.

16 Nov 2021

New metabolic vulnerabilities of subsets of triple-negative breast cancer discovered

Researchers have identified a metabolic enzyme and pathway in some triple-negative breast cancer (TNBC) patients, which they hope could serve as a biomarker to select patients to receive targeted therapy.

16 Nov 2021

Tricuspid-valve repair during mitral-valve surgery may benefit some patients

An international study of more than 400 adults concludes that people who undergo mitral valve surgery (between the left atrium and the left ventricle of the heart) and also have less than severe leakage of the tricuspid valve (a section of the heart that directs blood from the right atrium to the ventricle) may benefit from having both valves repaired at the same time.

16 Nov 2021

Unprecedented manufacturing strategy provides a template for equitable supply of vaccines

Today, as AstraZeneca reports 2 billion doses of the COVID-19 vaccine released for supply University of Oxford scientists explain how it has been possible to produce so much of the vaccine in less than a year, and the unprecedented strategy used to improve international equity of access.

16 Nov 2021

Drug improved cardiac structure and function in patients with early-stage hypertrophic cardiomyopathy

Valsartan, an angiotensin II receptor blocker drug, delayed disease progression and improved cardiac structure and function in patients with early-stage hypertrophic cardiomyopathy, according to results from a recent clinical trial published in Nature Medicine.

16 Nov 2021

Modeling the role of antivirals in suppressing the COVID-19 pandemic

A new study used an agent-based mathematical model to evaluate potential population impact on the widespread use of antiviral treatment for reducing viral load and hospitalization risk.

16 Nov 2021

Prescription omega-3 pill did not reduce hospitalization or death from COVID-19

A high dose of a purified omega-3 fatty acid, available by prescription only, was well tolerated; however, it did not substantially reduce incidents of hospitalizations and/or deaths among people with COVID-19, according to a late-breaking clinical trial presented today at the American Heart Association's Scientific Sessions 2021.

15 Nov 2021

Common hypertension drug not effective in slowing down the progression of Alzheimer's disease

New research led by the University of Bristol, has shown the drug losartan, normally used to treat high blood pressure (hypertension), is not effective in slowing down the progression of Alzheimer's disease (AD) in people with mild-to-moderate disease after 12 months of treatment.

15 Nov 2021

Anticoagulants to prevent strokes do not provide adequate protection for hemodialysis patients

The anticoagulants currently used to prevent strokes in dialysis patients with atrial fibrillation do not provide adequate protection for this group.

15 Nov 2021

Clinical Trial News and Research

Mouthwash containing an antiviral phthalocyanine derivative shortens hospitalizations due to COVID-19

Anti-inflammatory drug used to treat gout does not reduce the risk of COVID-19 mortality

Oral Hsp90 inhibitor SNX-5422 interferes with replication machinery of SARS-CoV-2

UW researchers develop a wearable device to detect and reverse opioid overdose

‘Surgery selfies’ can help with early identification of infections

First long-acting injectable HIV treatment appraised and approved by NICE

A nasal COVID vaccine using a weakened influenza vector

Study involving a rat model offers potential treatment for Alexander disease

New test enables patient-specific monitoring and treatment for ovarian cancer

Researchers receive $22 million grant for clinical trial that aims to reduce lung transplant rejection

Short-term severe calorie restriction safe, feasible, and well tolerated by cancer patients

Tighter blood pressure management may lead to better spinal cord injury recovery

New metabolic vulnerabilities of subsets of triple-negative breast cancer discovered

Tricuspid-valve repair during mitral-valve surgery may benefit some patients

Unprecedented manufacturing strategy provides a template for equitable supply of vaccines

Drug improved cardiac structure and function in patients with early-stage hypertrophic cardiomyopathy

Modeling the role of antivirals in suppressing the COVID-19 pandemic

Prescription omega-3 pill did not reduce hospitalization or death from COVID-19

Common hypertension drug not effective in slowing down the progression of Alzheimer's disease

Anticoagulants to prevent strokes do not provide adequate protection for hemodialysis patients

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