Preclinical News and Research

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International project to develop globally accessible bank of new cancer cell models for research

An international project to develop a large, globally accessible bank of new cancer cell culture models for the research community launched today.

12 Jul 2016

Aelan's researchers develop novel epigenetic biomarker for diagnosis of AD

Aelan Cell Technologies today announced the development of a novel epigenetic biomarker. An early human clinical feasibility study has indicated that serological tests using the biomarker alongside other proprietary components developed by Aelan's researchers could potentially help physicians diagnose Alzheimer's disease (AD).

12 Jul 2016

Leukemia drug increases brain dopamine, lowers toxic proteins linked to Parkinson's or dementia

A small phase I study provides molecular evidence that an FDA-approved drug for leukemia significantly increased brain dopamine and reduced toxic proteins linked to disease progression in patients with Parkinson's disease or dementia with Lewy bodies.

12 Jul 2016

Nanoscope researchers develop novel VMCO and NOD platform for patients with vision loss

According to the World Health Organization, approximately 285 million people are estimated to be visually impaired worldwide. Age-related macular degeneration (AMD) is a major cause of vision loss in aging populations.

11 Jul 2016

Five-year NIH grant awarded to four NYC medical centers for PMI Cohort Program

Columbia University Medical Center and Weill Cornell Medicine, in collaboration with NewYork-Presbyterian and NYC Health + Hospitals/Harlem, have been awarded a grant from the NIH for approximately $4 million in fiscal year 2016 to enroll participants in the Cohort Program of President Barack Obama's Precision Medicine Initiative (PMI)—a large-scale research effort to improve our ability to prevent and treat disease based on individual differences in lifestyle, environment and genetics.

11 Jul 2016

Sex-related difference could have impact on treatment of metabolic diseases

In health research, most preliminary studies in animals only examine effects of drug treatment in one sex, assuming that males and females will have few differences in how a drug works.

8 Jul 2016

Scientists identify how tumor cells exploit function of mitochondria to support cancer proliferation

As the powerhouse of the cells, mitochondria are critical for every organism because of their role in producing energy while also controlling survival, but how they function in cancer is still not completely known.

8 Jul 2016

Study shows twice daily exercise intervention improves bone strength in VLBW pre-term infants

Because of their low weight and premature birth, very low birth weight (VLBW) pre-term infants have lower bone mineral mass and a greater need for bone nutrients compared to most new-born infants.

7 Jul 2016

MGH researchers discover how obesity increases inflammation, desmoplasia in PDAC patients

Massachusetts General Hospital investigators have discovered the mechanism by which obesity increases inflammation and desmoplasia - an accumulation of connective tissue - in the most common form of pancreatic cancer.

7 Jul 2016

Study underscores importance of targeting prevention efforts at preclinical HF stages

According to a recent study of Framingham Study participants, nearly 60 percent of people have prevalent preclinical heart failure (HF) stages A and B. Heart failure occurs when the heart muscle is weakened and cannot pump enough blood to meet the body's needs for blood and oxygen.

7 Jul 2016

Minoryx Therapeutics initiates phase 1 clinical trial of MIN-102

Minoryx Therapeutics, a drug development company specialized in the discovery and development of new drugs for orphan diseases, today announces the initiation of its first-in-man Phase 1 clinical trial for its lead compound MIN-102.

7 Jul 2016

WRAIR collaborates with Sanofi Pasteur to develop ZPIV vaccine candidate

The Walter Reed Army Institute of Research announces a Cooperative Research and Development Agreement for the development of a Zika vaccine candidate with Sanofi Pasteur, the vaccines division of Sanofi.

7 Jul 2016

Tiny micro-vesicle structures may help predict probability of developing Alzheimer's dementia

Researchers at University of California San Diego School of Medicine say tiny micro-vesicle structures used by neurons and other cells to transport materials internally or dispose of them externally carry tell-tale proteins that may help to predict the likelihood of mild cognitive impairment (MCI) developing into full-blown Alzheimer's disease (AD).

6 Jul 2016

Researchers identify potential biomarker for Parkinson's disease in biobanked urine samples

For more than five years, urine and cerebral-spinal fluid samples from patients with Parkinson's disease have been locked in freezers in the NINDS National Repository, stored with the expectation they might someday help unravel the still-hidden course of this slow-acting neurodegenerative disease.

6 Jul 2016

Researchers demonstrate simple approach to prove how classes of new drugs work

A collaborative effort by cancer researchers at Cold Spring Harbor Laboratory and chemists at Boehringer Ingelheim, a pharmaceutical firm, has resulted in the identification of a new drug target in leukemia and creation of a candidate drug that hits the target.

6 Jul 2016

Novel high-resolution method helps study which genes are active in tissues

Scientists at Karolinska Institutet and the Royal Institute of Technology have devised a new high-resolution method for studying which genes are active in a tissue.

1 Jul 2016

Nutritional interventions may help prevent detrimental brain ageing

Ageing is a highly complex process marked by a succession of events that may lead to an altered brain function, including neurodegenerative diseases. To date, the precise cause of cognitive decline remains quite elusive.

1 Jul 2016

Researchers test experimental Zika virus vaccine in mice

An experimental vaccine against Zika virus developed by Brazilian and US researchers has been tested successfully in trials with mice.

30 Jun 2016

UTHealth researchers receive $11 million grant to study prion diseases

Led by Claudio Soto, Ph.D., researchers from McGovern Medical School at The University of Texas Health Science Center at Houston have been awarded $11 million from the National Institute of Allergy and Infectious Diseases to study the pathogenesis, transmission and detection of prion diseases - such as chronic wasting disease in deer - that can potentially spread to humans.

30 Jun 2016

New technology could help deliver treatments for brain injuries

A new study led by scientists at the Sanford Burnham Prebys Medical Discovery Institute describes a technology that could lead to new therapeutics for traumatic brain injuries. The discovery, published today in Nature Communications, provides a means of homing drugs or nanoparticles to injured areas of the brain.

29 Jun 2016

Preclinical News and Research

International project to develop globally accessible bank of new cancer cell models for research

Aelan's researchers develop novel epigenetic biomarker for diagnosis of AD

Leukemia drug increases brain dopamine, lowers toxic proteins linked to Parkinson's or dementia

Nanoscope researchers develop novel VMCO and NOD platform for patients with vision loss

Five-year NIH grant awarded to four NYC medical centers for PMI Cohort Program

Sex-related difference could have impact on treatment of metabolic diseases

Scientists identify how tumor cells exploit function of mitochondria to support cancer proliferation

Study shows twice daily exercise intervention improves bone strength in VLBW pre-term infants

MGH researchers discover how obesity increases inflammation, desmoplasia in PDAC patients

Study underscores importance of targeting prevention efforts at preclinical HF stages

Minoryx Therapeutics initiates phase 1 clinical trial of MIN-102

WRAIR collaborates with Sanofi Pasteur to develop ZPIV vaccine candidate

Tiny micro-vesicle structures may help predict probability of developing Alzheimer's dementia

Researchers identify potential biomarker for Parkinson's disease in biobanked urine samples

Researchers demonstrate simple approach to prove how classes of new drugs work

Novel high-resolution method helps study which genes are active in tissues

Nutritional interventions may help prevent detrimental brain ageing

Researchers test experimental Zika virus vaccine in mice

UTHealth researchers receive $11 million grant to study prion diseases

New technology could help deliver treatments for brain injuries

Event guide: 4th LNP Formulation & Process Development Summit eBook

Latest eBooks

Editorial Focus eBook - Spatial and single-cell omics (1st edition)

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Industry Focus eBook - Microbiome (1st edition)

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Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics