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The impact of mild SARS-CoV-2 infection on maternal-fetal immunity

Recently, a new study published on the pre-print server bioRxiv* examined the effect that maternal asymptomatic COVID-19 had on decidual and peripheral immune cells during the later stage of pregnancy.

30 Aug 2021

Polymeric and lipid nanoparticles in self-amplifying RNA vaccines result in higher protein expression and immunogenicity

Self-amplifying RNA (saRNA) is an advanced platform for nucleic acid vaccine development. The backbone is typically derived from an alphaviral genome and encodes a gene of interest (GOI) and a viral replicase that can amplify the genomic and subgenomic RNA.

30 Aug 2021

Next-gen COVID vaccine to make persistent neutralizing antibodies

Presently, there is a need to develop improved versions of COVID-19 vaccines that are effective against the SARS-CoV-2 variants of concern (VOC) and can confer long-term protection. Considering the need of the hour, scientists from the University of Sydney in Australia have generated a new COVID-19 vaccine CoVac-II and evaluated its effect against COVID-19 strains. The findings from this study are published on the bioRxiv* preprint server while awaiting peer review.

30 Aug 2021

Modeling of COVID-19 seroprevalence and resurgence in Canada

Despite increased vaccine distribution and a significant decrease in the number of COVID-19 cases in Canada, the future of the pandemic is still a major concern, based on the possibility of a resurgence in the short term as well as long term and an understanding of the future of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity. It is not clear if the Canadian population will reach herd immunity or if there is a risk of future resurgence of the virus in the Fall or Winter.

30 Aug 2021

Scientists analyze the impact of two strategies in stopping COVID-19 pandemic

How can we best organise on-site workplace and school attendance periods and remote work to slow the circulation of Sars-CoV-2? Is it better to separate classes? Bring your whole team in at the same time? Set this up on daily or weekly schedules?

28 Aug 2021

Northwestern researchers continue investigation on all aspects of COVID-19 pandemic

Northwestern Medicine scientists continue to investigate all aspects of the COVID-19 pandemic: from molecular mechanisms of infection, to child hospitalization and single-dose vaccine response.

28 Aug 2021

Bhutan starts immunizing children in the 12 to 19 age group against COVID-19

Bhutan is following up on its success in vaccinating 90 per cent of its adult population against COVID-19 by embarking on a plan to immunize children in the 12 to 19 age group.

27 Aug 2021

'Humanized' mouse model beats current approaches for finding the best organ donor

A "humanized" mouse model equipped with the immune system of a patient who needs an organ transplant beats current measures for identifying the best potential living donor, scientists report.

27 Aug 2021

COVID-19 vaccine potency has diminished in recent months, but still helps in saving lives

COVID-19 vaccines remain effective, but their potency has diminished in recent months, according to a nationwide study at eight sites, including Salt Lake City, Utah.

27 Aug 2021

Mild maternal infections can have permanent impacts on offspring immunity

During pregnancy, mild infections in the mother can have permanent and tissue-specific impacts on offspring immunity, according to a new study in mice.

27 Aug 2021

Potential variant of interest in South Africa assigned to the PANGO lineage C.1.2

Continual genomic surveillance of the SARS-CoV-2 strains in South Africa has revealed an increase in the number of sequences belonging to C.1 lineage during the third wave (May 2021) of SARS-CoV-2 infections. This observation was unexpected because C.1 was last reported in January 2021.

26 Aug 2021

Scientists assess SARS-CoV-2 mutants in ferret hosts

In a paper recently uploaded to the preprint server bioRxiv* by the cause of SARS-CoV-2 mutations observed in mink and ferrets is investigated, and the danger posed by such mutations to humans assessed.

26 Aug 2021

Analysis of antibody titer decay following vaccination or SARS-CoV-2 infection

A new study focused on the decrease in antibody titers following two doses of BNT162b2 vaccine or SARS-CoV-2 natural infection in Israel.

25 Aug 2021

Research highlights the potential benefits of SARS-CoV-2 S gene mutants as immunogens

Previous research has shown that the spike (S) protein of -CoV-2 binds to a host cell receptor, facilitating viral entry.

25 Aug 2021

Scientists forecast healthcare burden of future COVID waves

The findings indicate that given the lower vaccine efficacy against the SARS-CoV-2 delta variant, France may face a large epidemic wave infecting 25% of the general population even with a 95% vaccine coverage. This, in turn, could affect the healthcare system in terms of hospital bed occupancy. The study is currently available on the medRxiv* preprint server.

25 Aug 2021

SARS-CoV-2 Delta likely to acquire resistance to wild-type spike vaccines

A new study published on the preprint server bioRxiv* explores the mechanism of the Delta variant's high infectivity and suggests a plausible pathway by which the Delta variant could escape from vaccine-induced immunity.

24 Aug 2021

Breast milk of vaccinated mothers contains antibodies that may protect nursing infants from COVID-19

The breast milk of lactating mothers vaccinated against COVID-19 contains a significant supply of antibodies that may help protect nursing infants from the illness, according to new research from the University of Florida.

24 Aug 2021

New clinical trial to test third dose of COVID-19 vaccine for immunocompromised people

A new clinical trial to determine whether a third dose of vaccine will improve the immune response for people who have weakened immune systems is launching in the UK.

24 Aug 2021

SARS-CoV-2 Delta variant associated with more breakthrough infections

The study highlights that compared to the previously circulating alpha variant, the delta variant is associated with higher infectious virus load and a lower level of humoral immunity in the upper respiratory tract. The study is currently available on the medRxiv* preprint server prior to peer review.

24 Aug 2021

Researchers discover molecule that plays an important role in sperm motility regulation

About 120 million unintended pregnancies occurred each year between 2015 and 2019 worldwide. While there are oral contraceptives for women, the development of oral contraceptives for men has not been successful.

24 Aug 2021

immunity News and Research

The impact of mild SARS-CoV-2 infection on maternal-fetal immunity

Polymeric and lipid nanoparticles in self-amplifying RNA vaccines result in higher protein expression and immunogenicity

Next-gen COVID vaccine to make persistent neutralizing antibodies

Modeling of COVID-19 seroprevalence and resurgence in Canada

Scientists analyze the impact of two strategies in stopping COVID-19 pandemic

Northwestern researchers continue investigation on all aspects of COVID-19 pandemic

Bhutan starts immunizing children in the 12 to 19 age group against COVID-19

'Humanized' mouse model beats current approaches for finding the best organ donor

COVID-19 vaccine potency has diminished in recent months, but still helps in saving lives

Mild maternal infections can have permanent impacts on offspring immunity

Potential variant of interest in South Africa assigned to the PANGO lineage C.1.2

Scientists assess SARS-CoV-2 mutants in ferret hosts

Analysis of antibody titer decay following vaccination or SARS-CoV-2 infection

Research highlights the potential benefits of SARS-CoV-2 S gene mutants as immunogens

Scientists forecast healthcare burden of future COVID waves

SARS-CoV-2 Delta likely to acquire resistance to wild-type spike vaccines

Breast milk of vaccinated mothers contains antibodies that may protect nursing infants from COVID-19

New clinical trial to test third dose of COVID-19 vaccine for immunocompromised people

SARS-CoV-2 Delta variant associated with more breakthrough infections

Researchers discover molecule that plays an important role in sperm motility regulation

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