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Saliva test screenings contribute to low transmission of COVID-19 in schools for children with IDD

Studies have determined that in-school transmission of the virus that causes COVID-19 is rare when masking, social distancing and other safety protocols are followed.

1 Sep 2021

Studies outlines novel strategies for detecting cancer and minimal residual disease

The latest special issue of PLOS Medicine features five studies outlining novel strategies for detecting cancer and for identifying minimal residual disease - when a small number of tumor cells survive treatment, potentially leading to recurrence of cancer.

1 Sep 2021

Innovative AI and simulation tools used to reveal the inner workings of Sar-CoV-2 virus

Argonne, industry and academia collaborate to bring innovative AI and simulation tools to the COVID-19 battlefront.

1 Sep 2021

Sequential treatment using similar antibiotics can kill bacteria and prevent drug resistance

equential treatment using antibiotics that are similar but swapped around frequently is an effective way to kill bacteria and prevent drug resistance, a study in eLife reports.

1 Sep 2021

A global genetic surveillance gap for SARS-CoV-2

Now a new study posted to the medRxiv* preprint server provides a perspective on the global disparities surrounding SARS-CoV-2 genomic surveillance, their causes and consequences, and possible solutions to maximize the impact of pathogen genome sequencing for efforts on public health.

1 Sep 2021

Liquid biopsies could help identify, track bladder cancer and peripheral nerve tumors

Liquid biopsies detect tumor DNA in blood or urine samples. Two studies led by Washington University School of Medicine in St. Louis describe the potential of liquid biopsies to identify and track tumor growth in two very different cancers: bladder cancer and peripheral nerve tumors.

31 Aug 2021

Blood test could enable early detection of cancer in people with neurofibromatosis type 1

People with an inherited condition known as neurofibromatosis type 1, or NF1, often develop non-cancerous, or benign, tumors that grow along nerves. These tumors can sometimes turn into aggressive cancers, but there hasn't been a good way to determine whether this transformation to cancer has happened.

31 Aug 2021

Genomic autopsy reveals many genetic variants associated with cardiomyopathy

Postmortem genetic testing, or genomic autopsy, of young individuals who experienced sudden death revealed many had known genetic variants that are associated with cardiomyopathy, according to a Northwestern Medicine study published in JAMA Cardiology.

31 Aug 2021

Anti-SARS-CoV-2 immunity induced by Pfizer/BioNTech vaccine may decline after 6 months

A team of scientists from Israel has recently claimed that antiviral immunity induced by the mRNA-based coronavirus disease 2019 (COVID-19) BNT162b2 gradually declines over time, highlighting the need for a third booster dose.

31 Aug 2021

Study compares risk of hospitalization from SARS-CoV-2 delta and alpha variants

Largest study to date analyzing more than 40,000 COVID-19 cases (including a combination of vaccinated and unvaccinated individuals) confirmed by virus genome sequencing finds a two-fold increased risk of hospitalization from delta versus alpha variant infections.

31 Aug 2021

New, one-stop method developed to avoid de novo genetic disease in embryos

De novo variants (DNVs), genetic mutations that were not previously identifiable in the family history of one of two prospective parents, may cause disease in any children they have.

31 Aug 2021

Finding the genetic cause of childhood epilepsy helps improve treatment and care

Epilepsy is one of the most common chronic neurological diseases, affecting more than 50 million people worldwide. Although it is believed that a large proportion of childhood-onset epilepsies are caused by genetic changes, it remains unknown precisely how many of these patients suffer from a genetic disorder and how often the treatment can be targeted to their specific genetic alteration.

31 Aug 2021

Study identifies actionable genes and candidate drugs in biliary tract cancer using a knowledgebase

Oncotarget published "Actionability evaluation of biliary tract cancer by genome transcriptome analysis and Asian cancer knowledgebase" which reported that it is necessary to investigate actionable genes and candidate drugs using a sophisticated knowledgebase and characterize BTCs immunologically for evaluating the actionability of molecular and immune therapies.

31 Aug 2021

Research sheds light on potential biological mechanisms that impact adherence to medications

How strictly patients follow a prescribed drug treatment (drug adherence) is clearly important if the therapy is to have maximum effect. A number of things can affect adherence, including behavioral and socioeconomic factors, but to date there have been few investigations into the role played by genetics. Now, research to be presented at the annual conference of the European Society of Human Genetics today has thrown new light on the potential biological mechanisms that can affect adherence to treatment.

31 Aug 2021

Gitelman syndrome more common in Japanese population than previously reported

Clinical Fellow KONDO Atsushi and Professor NOZU Kandai et al. of Kobe University's Graduate School of Medicine have estimated the prevalence of Gitelman syndrome across different ethnicities using a genome database.

30 Aug 2021

How early interferon curbs SARS-CoV-2 infection

A new study available in the Journal of Experimental Medicine focuses on the importance of interferon in SARS-CoV-2 infection.

30 Aug 2021

Prevalence of vaccine breakthrough cases in SF Bay Area

A new study focuse on studying breakthrough infections in a highly vaccinated community owing to the emergence of SARS-CoV-2 variants.

30 Aug 2021

Could genetic variants in host cell receptors (ACE2) explain COVID-19 susceptibility among certain ethnic groups?

Led by Ioannis Karakikes of Stanford University, a new study suggests some hospitalized patients with COVID-19 contain ACE2 genetic variants that increase ACE2 expression. Some variants that altered ACE2 protein expression and binding affinity were more prevalent in people with European backgrounds.

30 Aug 2021

Molecular autopsy of dried blood spots can identify underlying cause of sudden cardiac death in a young person

The underlying cause of sudden cardiac death (SCD) in a young person is often difficult to identify. A genetic analysis could provide more information in many cases, but blood samples are not collected routinely at the time of death, and DNA extracted from the tissues collected at autopsy is damaged because of the way they are fixed in formalin and paraffin-embedded.

30 Aug 2021

New study maps the evolution of the SARS-CoV-2 delta and delta plus variants

The SARS-CoV-2 delta variant bears the D164G mutation, which is known to enhance viral fitness. However, a number of additional mutations are known to be common to the delta and delta plus lineages, at least 25 as identified in a study recently published in the Journal of Autoimmunity, mainly located on the spike protein of the virus.

30 Aug 2021

Genome News and Research

Saliva test screenings contribute to low transmission of COVID-19 in schools for children with IDD

Studies outlines novel strategies for detecting cancer and minimal residual disease

Innovative AI and simulation tools used to reveal the inner workings of Sar-CoV-2 virus

Sequential treatment using similar antibiotics can kill bacteria and prevent drug resistance

A global genetic surveillance gap for SARS-CoV-2

Liquid biopsies could help identify, track bladder cancer and peripheral nerve tumors

Blood test could enable early detection of cancer in people with neurofibromatosis type 1

Genomic autopsy reveals many genetic variants associated with cardiomyopathy

Anti-SARS-CoV-2 immunity induced by Pfizer/BioNTech vaccine may decline after 6 months

Study compares risk of hospitalization from SARS-CoV-2 delta and alpha variants

New, one-stop method developed to avoid de novo genetic disease in embryos

Finding the genetic cause of childhood epilepsy helps improve treatment and care

Study identifies actionable genes and candidate drugs in biliary tract cancer using a knowledgebase

Research sheds light on potential biological mechanisms that impact adherence to medications

Gitelman syndrome more common in Japanese population than previously reported

How early interferon curbs SARS-CoV-2 infection

Prevalence of vaccine breakthrough cases in SF Bay Area

Could genetic variants in host cell receptors (ACE2) explain COVID-19 susceptibility among certain ethnic groups?

Molecular autopsy of dried blood spots can identify underlying cause of sudden cardiac death in a young person

New study maps the evolution of the SARS-CoV-2 delta and delta plus variants

The art of CRISPR: The power and promise of gene editing eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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