Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Regulus begins ATHENA study to monitor changes in renal function in Alport syndrome patients

Regulus Therapeutics Inc., a biopharmaceutical company leading the discovery and development of innovative medicines targeting microRNAs, announced today it has initiated its ATHENA natural history of disease study in patients with Alport syndrome, a life-threatening genetic kidney disease with no approved therapy.

19 Sep 2014

Immune begins bertilimumab Phase II clinical trial for treatment of ulcerative colitis

Immune Pharmaceuticals Inc. announces today that it has initiated the screening of patients for a Phase II proof of concept clinical trial exploring the safety and efficacy of bertilimumab in the treatment of ulcerative colitis (UC).

18 Sep 2014

Urinary nerve growth factor shows diagnostic value

Urinary nerve growth factor could be a useful biomarker for the diagnosis of overactive bladder and a predictive biomarker to help guide treatment, Chinese researchers believe.

17 Sep 2014

UCSD researchers launch phase 1 trial to assess novel monoclonal antibody for CLL patients

Researchers at the University of California, San Diego School of Medicine have launched a phase 1 human clinical trial to assess the safety and efficacy of a new monoclonal antibody for patients with chronic lymphocytic leukemia (CLL), the most common form of blood cancer in adults.

17 Sep 2014

Denovo gains all rights from Lilly to develop, manufacture and commercialize enzastaurin drug

Denovo Biopharma, LLC, today announced that it has acquired enzastaurin, a late-stage oncology drug, from Eli Lilly and Company. Denovo gains all rights to develop, manufacture and commercialize enzastaurin globally, including transfer of all intellectual property and other rights, data, and information.

16 Sep 2014

Dairy products contribute to overall metabolic health

Dairy is considered part of a healthy diet and dietary guidelines recommend the daily consumption of 2-4 portions of milk-based products such as milk, yogurt, cheese, cream and butter.

16 Sep 2014

Specific blood test could indicate neoadjuvant treatment regimens for ESCC patients

A blood test may be beneficial in indicating neoadjuvant treatment regimens for patients with esophageal squamous cell carcinoma (ESCC), according to research presented today at the American Society for Radiation Oncology's 56th Annual Meeting.

16 Sep 2014

Researchers find new method to measure modified protein structures in biological sample

Cells regulate protein functions in a wide variety of ways, including by modifying the protein structure. In an instant, a protein can take on another form and perform no or even the "wrong" function: in humans, proteins that fold wrongly can cause serious diseases such as Alzheimer's, Parkinson's or cystic fibrosis.

16 Sep 2014

Brain structure 'significantly predictive' of individual risk attitudes

There is a link between our brain structure and our tolerance of risk, new research suggests.

15 Sep 2014

Researchers identify non-protein-coding RNA whose expression linked to ovarian cancer

Over the years researchers have made tremendous strides in the understanding and treatment of cancer by searching genomes for links between genetic alterations and disease.

10 Sep 2014

Scientists identify how immune cells use two critical receptors to clear dead cells from the body

In most of the tissues of the body, specialized immune cells are entrusted with the task of engulfing the billions of dead cells that are generated every day.

8 Sep 2014

Using molecular imaging probes diabetic retinopathy can be detected at molecular level

A new study published in the September issue of The FASEB Journal, identifies a novel strategy to diagnose the leading cause of blindness in adults, diabetic retinopathy, before irreversible structural damage has occurred.

3 Sep 2014

Researchers come up with new technique to diagnose malaria

Over the past several decades, malaria diagnosis has changed very little. After taking a blood sample from a patient, a technician smears the blood across a glass slide, stains it with a special dye, and looks under a microscope for the Plasmodium parasite, which causes the disease.

1 Sep 2014

Pharmatech begins enrollment for AccessPPM program

Pharmatech initiated enrollment for its AccessPPM program after a two-year investment into this game-changing method for matching cancer patients to cancer clinical trials.

29 Aug 2014

New biomarker may improve diagnosis of early-stage rheumatoid arthritis

A novel biomarker for rheumatoid arthritis (RA) has significant potential to help physicians better identify early-stage disease, when treatment can often arrest further disease progression and disability, according to a new study in The Journal of Rheumatology.

From Quest Diagnostics 28 Aug 2014

Protein p66ShcA shows promise as biomarker to identify breast cancers with poor prognoses

A protein named p66ShcA shows promise as a biomarker to identify breast cancers with poor prognoses, according to research published ahead of print in the journal Molecular and Cellular Biology.

26 Aug 2014

Research to determine breath test's effectivness in patient with COPD

NYU Langone Medical Center will lead a new clinical initiative -- funded by a $225,000 grant from The National Institutes of Health -- to determine a breath test's effectivness to identify volatile organic compounds (VOCs) in human breath that are biomarkers of chronic obstrutive pulmonary disease (COPD).

26 Aug 2014

Spring Bioscience launches PD-L1 (SP142) rabbit monoclonal immunohistochemistry antibody1

Spring Bioscience (Spring), a member of the Roche Group, today announced the launch of its PD-L1 (SP142) rabbit monoclonal immunohistochemistry (IHC) antibody.

25 Aug 2014

Study finds a host of new clues on gene-environment interactions in Crohn's disease

A new study finds a wide range of epigenetic changes-alterations in DNA across the genome that may be related to key environmental exposures-in children with Crohn's disease (CD), reports Inflammatory Bowel Diseases, official journal of the Crohn's & Colitis Foundation of America.

23 Aug 2014

Scientists discover predictive marker to classify breast cancer patients for effective treatment

Scientists have made it easier to predict both breast cancer relapses and responses to chemotherapy, through the identification of a unique gene. The newly found marker could help doctors classify each breast cancer patient and customise a treatment regimen that is more effective.

21 Aug 2014

Biomarker News and Research

Further Reading

Regulus begins ATHENA study to monitor changes in renal function in Alport syndrome patients

Immune begins bertilimumab Phase II clinical trial for treatment of ulcerative colitis

Urinary nerve growth factor shows diagnostic value

UCSD researchers launch phase 1 trial to assess novel monoclonal antibody for CLL patients

Denovo gains all rights from Lilly to develop, manufacture and commercialize enzastaurin drug

Dairy products contribute to overall metabolic health

Specific blood test could indicate neoadjuvant treatment regimens for ESCC patients

Researchers find new method to measure modified protein structures in biological sample

Brain structure 'significantly predictive' of individual risk attitudes

Researchers identify non-protein-coding RNA whose expression linked to ovarian cancer

Scientists identify how immune cells use two critical receptors to clear dead cells from the body

Using molecular imaging probes diabetic retinopathy can be detected at molecular level

Researchers come up with new technique to diagnose malaria

Pharmatech begins enrollment for AccessPPM program

New biomarker may improve diagnosis of early-stage rheumatoid arthritis

Protein p66ShcA shows promise as biomarker to identify breast cancers with poor prognoses

Research to determine breath test's effectivness in patient with COPD

Spring Bioscience launches PD-L1 (SP142) rabbit monoclonal immunohistochemistry antibody1

Study finds a host of new clues on gene-environment interactions in Crohn's disease

Scientists discover predictive marker to classify breast cancer patients for effective treatment

Event guide: World Clinical Biomarkers & CDx Summit Japan eBook

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