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New streamlined approach for high-coverage genome sequencing of single yeast cells

A single cell can reveal much about the biological world through genomic sequencing. Scientists can compare a single, isolated cell to other samples, analyzing the differences and similarities to better understand how the organisms originated and evolved - or even to discover entirely new species.

6 Aug 2021

Study uncovers link between corticosteroid receptors and ciliary, neuroplasticity genes in the brain

Chronic stress is a well-known cause for mental health disorders. New research has moved a step forward in understanding how glucocorticoid hormones ('stress hormones') act upon the brain and what their function is.

6 Aug 2021

Research reveals a microRNA network as putative mediators of myocardial reductive stress

Last year, University of Alabama at Birmingham researchers reported that reductive stress - an imbalance in the normal oxidation/reduction homeostasis - caused pathological changes associated with heart failure in a mouse model.

6 Aug 2021

Researchers create new model for studying earliest stages of retinoblastoma

Scientists at St. JudeChildren's Research Hospital have created a laboratory model for studying retinoblastoma driven by inherited mutations in theRB1gene.Retinoblastoma is a rare cancer of the retina, the thin tissue inside the back of the eye.

6 Aug 2021

Researchers identify genetic markers linked to COVID-19 severity and susceptibility

In collaboration with Northwestern Medicine investigators, an international multi-center study has identified genetic factors associated with SARS-CoV-2 infection and COVID-19 severity, according to findings published in Nature.

6 Aug 2021

New method for producing pseudotyped virus particles bearing spike protein of SARS-CoV-2

A new study discusses the development of an improved protocol based on cell lines that can consistently express S proteins.

5 Aug 2021

PD1 gene deletions associated with worse prognoses of cutaneous T-cell lymphomas

Immunohistochemistry staining showing PD1 expression on tumor cells in a skin biopsy from a cutaneous T-cell lymphoma patient.

5 Aug 2021

Activation of NLRP3 inflammasome by the N protein of SARS-CoV-2 to induce hyperinflammation

A new study has revealed the mechanism by which the SARS-CoV-2 N protein activates NLRP3 inflammasomes to induce hyperinflammation.

5 Aug 2021

Researchers develop the most comprehensive molecular map of lung squamous cell carcinoma

Lung cancer remains the leading cause of cancer-associated death in the United States and worldwide. Patients with a subtype called lung adenocarcinoma (LUAD) have benefited from the development of new targeted medicines, but the search for effective new therapies for another subtype called lung squamous cell carcinoma (LSCC) has largely come up short.

5 Aug 2021

Mutation in a single gene may be responsible for non-obstructive azoospermia in men

Mutation in a single gene appears to account for a form of male infertility in which men fail to produce sperm, according to an international study funded in part by the National Institutes of Health.

5 Aug 2021

Using two different CRISPR enzymes to develop a faster and easier COVID-19 diagnostic test

Frequent, rapid testing for COVID-19 is critical to controlling the spread of outbreaks, especially as new, more transmissible variants emerge.

5 Aug 2021

New DNA writing technique can precisely and efficiently edit bacterial genomes

Biological engineers at MIT have devised a new way to efficiently edit bacterial genomes and program memories into bacterial cells by rewriting their DNA.

5 Aug 2021

Immunocompromised patients could be potential hosts for immune-escape mutants of SARS-CoV-2

In a recently published article in The New England Journal of Medicine, scientists have described how multi-mutational variants of SARS-CoV-2 may evolve in patients with immunosuppression.

5 Aug 2021

Bacteriophages named after Norfolk village of Colney could help combat C. difficile infections

Viruses have a menacing reputation for causing disease but some that target bacteria could actually benefit human health.

5 Aug 2021

Study offers molecular views on how olfactory receptors work

All senses must reckon with the richness of the world, but nothing matches the challenge faced by the olfactory system that underlies our sense of smell.

4 Aug 2021

Researchers make a breakthrough in understanding the genesis of uterine leiomyomas

Scientists at the University of Helsinki and Helsinki University Hospital have made a breakthrough in understanding the genesis of uterine leiomyomas, also called fibroids.

4 Aug 2021

Researchers develop nanofibrous filters that can capture and kill airborne coronaviruses under visible light irradiation

A new study discusses the development of photosensitized electrospun nanofibrous membranes capable of capturing and inactivating SARS-CoV-2 aerosols.

4 Aug 2021

Study provides new insights for understanding dynamic changes in immune responses to COVID-19

A KAIST immunology research team found that a specific subtype of macrophages that originated from blood monocytes plays a key role in the hyper-inflammatory response in SARS-CoV-2 infected lungs, by performing single-cell RNA sequencing of bronchoalveolar lavage fluid cells.

4 Aug 2021

Next-Generation Sequencing and the Diagnosis of Disease

In this interview, Professor John Rossen talks about next-generation sequencing and it's implications for the diagnosis of disease.

From Tecan 4 Aug 2021

Feinstein Institutes awarded $2.9 million NIH funding for polygenic embryo selection studies

Genetic testing and selection of embryos generated from in vitro fertilization have given rise to the controversial “designer baby” debate.

4 Aug 2021

Genome News and Research

New streamlined approach for high-coverage genome sequencing of single yeast cells

Study uncovers link between corticosteroid receptors and ciliary, neuroplasticity genes in the brain

Research reveals a microRNA network as putative mediators of myocardial reductive stress

Researchers create new model for studying earliest stages of retinoblastoma

Researchers identify genetic markers linked to COVID-19 severity and susceptibility

New method for producing pseudotyped virus particles bearing spike protein of SARS-CoV-2

PD1 gene deletions associated with worse prognoses of cutaneous T-cell lymphomas

Activation of NLRP3 inflammasome by the N protein of SARS-CoV-2 to induce hyperinflammation

Researchers develop the most comprehensive molecular map of lung squamous cell carcinoma

Mutation in a single gene may be responsible for non-obstructive azoospermia in men

Using two different CRISPR enzymes to develop a faster and easier COVID-19 diagnostic test

New DNA writing technique can precisely and efficiently edit bacterial genomes

Immunocompromised patients could be potential hosts for immune-escape mutants of SARS-CoV-2

Bacteriophages named after Norfolk village of Colney could help combat C. difficile infections

Study offers molecular views on how olfactory receptors work

Researchers make a breakthrough in understanding the genesis of uterine leiomyomas

Researchers develop nanofibrous filters that can capture and kill airborne coronaviruses under visible light irradiation

Study provides new insights for understanding dynamic changes in immune responses to COVID-19

Next-Generation Sequencing and the Diagnosis of Disease

Feinstein Institutes awarded $2.9 million NIH funding for polygenic embryo selection studies

The art of CRISPR: The power and promise of gene editing eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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