Brain Tumor News and Research

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A Brain Tumor is the growth of abnormal cells in the tissues of the brain. Brain tumors can be benign (not cancer) or malignant (cancer).

New guidelines and standards for the treatment of brain tumor complications

The brain can be affected by a number of different types of tumor and this leads to serious complications such as epileptic attacks, brain edema, hemorrhage, or thrombosis.

9 Dec 2020

Dexamethasone use could reduce immune checkpoint inhibitor efficacy in glioblastoma patients

Bottom Line: Among patients with glioblastoma receiving an immune checkpoint inhibitor, those who received the corticosteroid dexamethasone at baseline for cerebral edema had significantly worse overall survival.

25 Nov 2020

Polymeric nanomicelles effectively deliver anti-cancer drugs to glioblastoma

Using practical nano-DDS technology, a polymeric nanomicelle that effectively delivers the potent mitotic inhibitor desacetyl vinblastine hydrazide (DAVBNH) to glioblastoma (GBM) was developed.

12 Nov 2020

Men and women may require different brain tumor therapy, study finds

The current study shows that the sex differences in the tumor phenotype vary with the effect of the enhancer regulatory molecule bound to Brd4 on the course of stem cell-like differentiation in male and female GBM cells. Inhibition of Brd4 by genetic and pharmacological factors also varies in males and females, both in vivo and in vitro.

11 Nov 2020

Synthetic protein nanoparticle may treat aggressive brain cancer

A new synthetic protein nanoparticle capable of slipping past the nearly impermeable blood-brain barrier in mice could deliver cancer-killing drugs directly to malignant brain tumors, new research from the University of Michigan shows.

11 Nov 2020

Repurposing an anxiety drug to increase the efficacy of therapies for metastatic melanoma

There are times when adding something new to the mix makes it better. Give Popeye some spinach, and you've got a fighting machine. Give Mario a mushroom, and he becomes invincible. Without drinking a potion, Alice in Wonderland would never fit through the door.

5 Nov 2020

Preliminary analysis of photon therapy treatment group 1 shows no significant differences between arms

A preliminary analysis of photon therapy treatment group 1 from the phase II NRG Oncology clinical trial NRG-BN001 indicates that there is no statistically significant overall survival (OS) or toxicity differences between dose-intensification radiation therapy (DI-RT) using intensity-modulated radiation therapy (IMRT) and standard-dose radiation therapy (SD-RT) with temozolomide treatments for patients with newly diagnosed glioblastoma (GBM).

27 Oct 2020

MRI exams can be safely performed in patients with non-MR compatible cardiac devices

MRI examinations can be performed safely in patients with non-MR compatible cardiac devices, including those who are pacemaker-dependent or have abandoned leads, according to a study published in Radiology: Cardiothoracic Imaging.

22 Oct 2020

Tumor DNA in spinal fluid can help track children with aggressive brain tumors

For many cancers, doctors are increasingly looking to the DNA that solid tumors shed into the blood stream to help with diagnosis and monitoring. But brain cancer has been a different story thanks to the natural blockade created by the blood-brain barrier.

22 Oct 2020

Scientists develop a way to accurately detect and monitor common pediatric brain cancer

A team of scientists at Texas A&M University, Baylor College of Medicine and Texas Children's Hospital have developed a way to more accurately both detect and monitor a common type of pediatric brain cancer, setting the stage for giving clinicians a real-time view into how the cancer responds to treatment.

21 Oct 2020

New surgical tendon fixation system granted FDA 510(k) clearance

A new surgical tendon fixation system that not only re-attaches damaged tissues but also facilitates healing as it is absorbed by the body has been granted 510(k) clearance by the U.S. Food and Drug Administration, indicating that the device is "as safe and effective" as other legally marketed devices and is ready to go to market.

21 Oct 2020

Bioceramic implant can stimulate skull bone regeneration

A bioceramic implant has proved to stimulate regeneration of natural skull bone, so that even large cranial defects can be repaired in a way that has not been possible before. The research, led from the University of Gothenburg, is now presented in the scientific journal PNAS.

19 Oct 2020

Researchers develop breakthrough blood test for brain tumors

Genetic mutations that promote the growth of the most common type of adult brain tumors can be accurately detected and monitored in blood samples using an enhanced form of liquid biopsy developed by researchers at Massachusetts General Hospital.

14 Oct 2020

Researchers develop mitochondrial-targeted prodrug for treating glioblastoma

Houston Methodist researchers found that mice harboring human glioblastoma tumors in their brains had greatly enhanced survival and weight gain when given a newly developed prodrug.

9 Oct 2020

New strategic collaboration to accelerate treatments for unmet medical needs in oncology

The University of Texas MD Anderson Cancer Center and Taiho Pharmaceutical Co., Ltd., today announced a three-year strategic collaboration to accelerate the development of treatments for significant unmet medical needs in oncology, including patients with brain metastases and those with cancers refractory to available therapies.

25 Sep 2020

Researchers secure NIH funding to study differences in glioblastoma between males and females

A team led by researchers from Case Western Reserve University School of Medicine and Cleveland Clinic Lerner Research Institute has secured $10.4 million over five years from the National Institutes of Health/National Cancer Institute to explore at the molecular level the differences in glioblastoma between males and females.

17 Sep 2020

New approach can make immunotherapy effective against cancers

If cancer is a series of puzzles, a new study pieces together how several of those puzzles connect to form a bigger picture.

3 Sep 2020

FDA grants rare disease designations to investigational brain tumor drug

The U.S. Food and Drug Administration has awarded Rare Pediatric Disease Designation (RPDD) for diffuse intrinsic pontine glioma (DIPG) and Orphan Drug Designation for treatment of malignant glioma to OKN-007, an investigational drug discovered at the Oklahoma Medical Research Foundation and being developed by Oblato, Inc.

2 Sep 2020

Adjuvant chemotherapy can improve overall survival in patients with high-risk, low-grade glioma

A practice-changing study, NRG Oncology clinical trial NRG-RTOG 9802, has demonstrated, for the first time, a survival benefit of adjuvant chemotherapy following radiotherapy over radiotherapy alone in certain subgroups of patients with high-risk, low-grade glioma (WHO classification: LGG, grade II), a type of brain tumor that originates from glial cells.

1 Sep 2020

Researchers find way to make pediatric brain cancers respond better to therapies

Brain cancer in children is always a devastating diagnosis, but McMaster University researchers may have found a way to have the most serious types of pediatric brain cancer respond better to therapies.

28 Aug 2020