Exhaustion News and Research

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Functional impairment of HIV-specific T cells precedes aborted virus control

HIV is a master of evading the immune system, using a variety of methods to prevent the body from being able to find and kill it.

13 Sep 2021

Cellular program could turn T cells into effective cancer killers

Cancer-fighting immune cells in patients with lung cancer whose tumors do not respond to immunotherapies appear to be running on a different "program" that makes them less effective than immune cells in patients whose cancers respond to these immune treatments, suggests a new study led by researchers at the Johns Hopkins Kimmel Cancer Center Bloomberg~Kimmel Institute for Cancer Immunotherapy.

9 Sep 2021

Stem-like T cells within certain lymph nodes could be natural cancer fighters, study shows

In a new study by Yale Cancer Center, researchers show stem-like T cells within certain lymph nodes could be natural cancer fighters.

3 Sep 2021

More than one-third of physician assistants suffer from burnout, study reports

More than one-third of physician assistants meet criteria for burnout, suggests a study in the September issue of JAAPA, Journal of the American Academy of PAs. The journal is published in the Lippincott portfolio by Wolters Kluwer.

28 Aug 2021

Patients on dialysis show reduced antibody levels four months after COVID-19 vaccination

A new longitudinal study posted to the medRxiv* preprint server suggests vaccinated patients on chronic hemodialysis having waning immunity against severe acute respiratory syndrome 2 (SARS-CoV-2) variants of concern. The German researchers found a drop in neutralizing antibody levels and T cell activity four months after receiving their second Pfizer-BioNTech vaccine.

24 Aug 2021

New mathematical model can predict the optimum exercise regime for building muscle

Researchers have developed a mathematical model that can predict the optimum exercise regime for building muscle.

23 Aug 2021

As temperatures rise, so do the health risks for California’s farmworkers

Leoncio Antonio Trejo Galdamez, 58, died in his son's arms on June 29 after spending the day laying irrigation pipes in California's Coachella Valley. News of his death reverberated through the largely Latino community near the Mexican and Arizona borders — another casualty in a dangerous business.

23 Aug 2021

Study identifies mechanism of resistance and presents a much-needed target for advanced leukemias

Too many "exhausted" T cells left in the wake of aggressive chemotherapy regimens for patients with advanced chronic lymphocytic leukemia (CLL) make it more challenging for chimeric antigen receptor (CAR) T cell therapy to do its job.

16 Aug 2021

Weighted restraint linked to increased breathing effort after physical exercise

Weighted restraint, which is used in law enforcement when officers apply their body weight to a subject to control their movements during apprehension, is associated with increased breathing effort after physical exercise, according to a study published in Scientific Reports.

12 Aug 2021

Mount Sinai study discovers an important clue to multisystem inflammatory syndrome in children

Mount Sinai researchers have found an important clue to a rare but serious aftereffect of COVID-19 in children, known as a multisystem inflammatory syndrome in children or MIS-C.

11 Aug 2021

Long COVID may be due to persistent immune disturbances

A new study discusses abnormalities in the immune response following COVID-19 in samples collected from patients who have recovered from COVID-19.

8 Aug 2021

New immunotherapy strategy can eliminate pancreatic tumors in mice

Pancreatic cancer, which affects about 60,000 Americans every year, is one of the deadliest forms of cancer. After diagnosis, fewer than 10 percent of patients survive for five years.

6 Aug 2021

Poor wellbeing of healthcare employees reflects in patient satisfaction

Intensified job demands create serious risks to the wellbeing of employees. In healthcare, employee wellbeing is also reflected in patient satisfaction. Under a heavy workload, even positive challenges such as learning new things are experienced as increased stress.

2 Aug 2021

Research shows how brain mechanisms of fatigue influence people’s motivation to work

Fatigue - the feeling of exhaustion from doing effortful tasks - is something we all experience daily. It makes us lose motivation and want to take a break.

28 Jul 2021

Exhausted T cells linked to increased risk of COVID-19 mortality

New research led by Nadia R. Roan of Gladstone Institutes and the University of California, San Francisco, finds a correlation between high numbers of inflammatory CXCR4+ T cells and regulatory T cells specific to SARS-CoV-2 and dying from infection. In contrast, people who recovered from severe COVID-19 illness were more likely to have many SARS-CoV-2-specific T cells that perform homeostatic proliferation.

20 Jul 2021

T cells can be engineered to fight tumors without succumbing to exhaustion

Fighting a tumor is a marathon, not a sprint. For cancer-fighting T cells, the race is sometimes just too long, and the T cells quit fighting. Researchers even have a name for this phenomenon: T cell exhaustion.

19 Jul 2021

Food insufficiency associated with lack of mental health support during COVID-19 pandemic

A new national study published in Public Health Nutrition on July 15 found that Americans experiencing food insufficiency were three times as likely to lack mental health support during the COVID-19 pandemic than those not experiencing food insufficiency.

15 Jul 2021

Leading cardiovascular organizations call for global action to improve clinician well-being

Clinician well-being is imperative to providing high-quality patient care, yet clinician burnout continues to increase, especially over the last year due to the COVID-19 pandemic.

13 Jul 2021

Hematopoietic stem cells take advantage of 'junk' RNA to replenish the blood system

Chemotherapy is widely used to treat cancer patients. During the treatment, chemotherapeutic agents affect various biochemical processes to kill or reduce the growth of cancer cells, which divide uncontrollably in patients.

12 Jul 2021

Scientists discover drug candidates for treating liver fibrosis among pesticides

Skoltech biologists and their colleagues from Koltzov Institute of Developmental Biology, Russia, and the Chemistry Department of Taras Shevchenko University in Ukraine have discovered fairly unlikely drug candidates for treating liver fibrosis and other pathologies -- among pest control chemicals.

8 Jul 2021