Genome Editing News and Research

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New microcapsules represent promising vectors for application of genome-editing tools

Researchers from Tomsk Polytechnic University jointly with their colleagues from St. Petersburg, Hamburg and London have conducted a study in the course of which it was found out that polymer and hybrid silica-coated microcapsules are more efficient in genome-editing when applying CRISPR-Cas9 system.

6 Oct 2017

Researchers pinpoint genetic drivers of diffuse large B cell lymphoma

Lymphoma is the most common blood cancer, but the diagnosis belies a wildly diverse and little understood genetic foundation for the disease that hampers successful treatment.

5 Oct 2017

Study uses ferret model to elucidate key mechanisms for gyrus formation

The human brain is highly developed with higher functions compared to other animals, thanks to which humans are believed to have acquired special abilities. One of the important factors considered to contribute to the development of the brain is the gyrus, the fold on the cerebral cortex surface.

5 Oct 2017

Scientists use genome editing to understand role of a gene key to human embryonic development

Researchers have used a genome-editing technique to elucidate the role of a gene that is key to human embryonic development.

21 Sep 2017

Research could lead to improvements in treating diseases caused by mutations in genes

Research carried out by academics at Northumbria University, Newcastle could lead to improvements in treating patients with diseases caused by mutations in genes, such as cancer, cystic fibrosis and potentially up to 6,000 other inherited conditions.

19 Sep 2017

Scientists question CRISPR human embryo editing claims

A paper published in the journal Nature on the 2nd August described how a gene editing tool CRISPR could be used to correct a genetic mutation that leads to a heart condition. This team had performed the genetic editing on the gene sequences in dozens of viable human embryos to attempt to prevent a genetic heart condition called hypertrophic cardiomyopathy.

31 Aug 2017

Counteracting premature aging

Aging is the continuing process of such stress exposures, and with advancing age (normal aging), we must carry lots of senescent cells within our bodies. Senescent cells also often provide some ‘bad influences’ to surrounding healthy cells; such as chronic inflammation and tumorigenesis

14 Aug 2017

Genome editing – public perceptions studied

Genome editing is fast becoming a norm with more and more research teams working on this arena and coming up with new cutting edge developments. However attitudes towards genetic modifications vary with several opinions – political, moral and religious, raising concerns.

11 Aug 2017

Gene-therapy administered through skin transplants could enable treatment of many diseases

A research team based at the University of Chicago has overcome challenges that have limited gene therapy and demonstrated how their novel approach with skin transplantation could enable a wide range of gene-based therapies to treat many human diseases.

3 Aug 2017

IDT introduces first Cas9 enzyme variant that greatly reduces off-target effects in CRISPR genome editing

Integrated DNA Technologies today announced the launch of the first Cas9 enzyme variant that extensively reduces off-target effects in CRISPR genome editing without compromising on-target activity.

3 Aug 2017

Study shows new method for repairing disease-causing mutation in human embryos

Scientists have demonstrated an effective way of using a gene-editing tool to correct a disease-causing gene mutation in human embryos and stop it from passing to future generations.

3 Aug 2017

Research shows great potential of embryonic gene editing to prevent inherited diseases

Scientists have, for the first time, corrected a disease-causing mutation in early stage human embryos with gene editing.

2 Aug 2017

UNM professor receives $1.9-million NIH grant to battle against pervasive African parasite

UNM Distinguished Professor of Biology Eric S. Loker began studying the parasite that causes this disease more than three decades ago and is widely considered one of the world's foremost experts in this field. Loker was recently awarded a five-year, $1.9-million grant from the National Institutes of Health to continue his work in Africa.

2 Aug 2017

Researchers present novel gene-editing technique to prevent retinal angiogenesis

A research team from the Schepens Eye Research Institute of Massachusetts Eye and Ear has successfully prevented mice from developing angiogenesis of the retina--the sensory tissue at the back of the eye--using gene-editing techniques with CRISPR-Cas9.

25 Jul 2017

Cellectis wins European patent for CRISPR use in T-cells

Cellectis, a clinical-stage biopharmaceutical company focused on developing immunotherapies based on gene-edited CAR T-cells (UCART), today announced the grant by the European Patent Office of patent No. EP3004337 for the invention of using RNA-guided endonucleases, such as Cas9 or Cpf1 for the genetic engineering of T-cells.

24 Jul 2017

Researchers discover how new molecular scissors unzip and cleave DNA with high accuracy

Researchers from the University of Copenhagen (Denmark), led by the Spanish researcher Guillermo Montoya, have discovered how Cpf1, new molecular scissors unzip and cleave DNA.

6 Jul 2017

CNIO researchers optimize new system capable of generating cellular model of Ewing sarcoma

A team from the Spanish National Cancer Research Centre (CNIO) has optimized a system capable of generating a cellular model of Ewing sarcoma.

10 May 2017

New UCI Malaria Initiative aims to disrupt deadly disease transmission in Africa

University of California, Irvine vector biologist Anthony James will lead a multimillion-dollar effort to cultivate new strains of mosquitoes to fight malaria in Africa.

9 May 2017

EPFL researchers discover protein that kick-starts gene expression in nascent embryos

The formation of a human embryo starts with the fertilization of the oocyte by the sperm cell. This yields the zygote, the primordial cell that carries one copy each of the maternal and paternal genomes.

2 May 2017

Study: New gene editing strategy effectively targets cancer-causing ‘fusion genes’ in mouse models

A novel gene therapy using CRISPR genome editing technology effectively targets cancer-causing "fusion genes" and improves survival in mouse models of aggressive liver and prostate cancers, University of Pittsburgh School of Medicine researchers report in a study published online today in Nature Biotechnology.

2 May 2017

Genome Editing News and Research

New microcapsules represent promising vectors for application of genome-editing tools

Researchers pinpoint genetic drivers of diffuse large B cell lymphoma

Study uses ferret model to elucidate key mechanisms for gyrus formation

Scientists use genome editing to understand role of a gene key to human embryonic development

Research could lead to improvements in treating diseases caused by mutations in genes

Scientists question CRISPR human embryo editing claims

Counteracting premature aging

Genome editing – public perceptions studied

Gene-therapy administered through skin transplants could enable treatment of many diseases

IDT introduces first Cas9 enzyme variant that greatly reduces off-target effects in CRISPR genome editing

Study shows new method for repairing disease-causing mutation in human embryos

Research shows great potential of embryonic gene editing to prevent inherited diseases

UNM professor receives $1.9-million NIH grant to battle against pervasive African parasite

Researchers present novel gene-editing technique to prevent retinal angiogenesis

Cellectis wins European patent for CRISPR use in T-cells

Researchers discover how new molecular scissors unzip and cleave DNA with high accuracy

CNIO researchers optimize new system capable of generating cellular model of Ewing sarcoma

New UCI Malaria Initiative aims to disrupt deadly disease transmission in Africa

EPFL researchers discover protein that kick-starts gene expression in nascent embryos

Study: New gene editing strategy effectively targets cancer-causing ‘fusion genes’ in mouse models

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