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Researchers develop tool to measure biological age in individual cell types

A new priority research paper, featured as the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 22, was published on December 29, 2024. The paper is titled "Cell-type specific epigenetic clocks to quantify biological age at cell-type resolution."

2 Jan 2025

Study reveals how societal inequities influence brain aging and dementia

Researchers from Trinity College Dublin have collaborated with international partners to explore if societal inequality affects our brain.

27 Dec 2024

Researchers identify key mechanism linking brain stress to Alzheimer's disease

Researchers with the Advanced Science Research Center at the CUNY Graduate Center (CUNY ASRC) have unveiled a critical mechanism that links cellular stress in the brain to the progression of Alzheimer's disease (AD).

23 Dec 2024

Groundbreaking brain atlas sheds light on neural pathways for movement

Signals relayed to motor neurons from the brain enable muscle movement, but these signals typically pass through spinal interneurons before they reach their destination.

23 Dec 2024

The crucial role of 'chaperones' in maintaining neuronal function

A team of researchers from the University of Massachusetts Amherst is the first to show how proteins called "chaperones" are vital in ensuring that neurons can transmit signals to one another. When this neurotransmission breaks down, devastating diseases such as Alzheimer's and Parkinson's along with many others, can occur.

20 Dec 2024

Innovative method to study ALS could lead to personalized treatments

Amyotrophic lateral sclerosis (ALS) is a fast-progressing neurodegenerative disease with an average survival time of three years.

19 Dec 2024

New molecular insights into the early stages of Rett syndrome

Scientists investigating the severe developmental disorder known as Rett syndrome have discovered a series of crucial molecular changes that occur long before symptoms appear.

19 Dec 2024

The role of phytochemicals in combating metabolic diseases

This editorial reviews the impact of phytochemicals on metabolic diseases, emphasizing their potential in reducing inflammation and improving health outcomes.

19 Dec 2024

Brain's dual role in processing touch and hearing revealed

Ludwig van Beethoven began to lose his hearing at age 28 and was deaf by age 44. While the cause of his hearing loss remains a topic of scientific debate and ongoing revision, one thing is clear: Despite his hearing loss, Beethoven never ceased to compose music, likely because he was able to sense the vibrations of musical instruments and "hear" music through the sense of touch, researchers believe.

19 Dec 2024

Zebrafish study uncovers how ketamine affects brain cells to treat depression

The decades-old anesthetic ketamine could be a game changer for treating severe depression, but there are still many questions about how the drug works, including exactly how it affects the brain's cells and circuits.

17 Dec 2024

Researchers gain new insights into the molecular changes leading to Rett syndrome

Researchers at Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children's Hospital and collaborating institutions have gained new insights into the molecular changes leading to Rett syndrome, a severe neurological disorder caused by mutations in the MeCP2 gene encoding methyl-CpG binding protein 2 (MeCP2).

16 Dec 2024

TTUHSC researcher to uncover mechanisms that regulate gene expression in Alzheimer's disease

More than six million Americans are affected by Alzheimer's disease, a form of dementia marked by accumulation of amyloid-β within the brain. Amyloid-β is a relatively small protein that forms toxic plaques in the brain contributing to the harmful effects of Alzheimer's disease.

14 Dec 2024

Key plasma proteins signal critical periods in brain aging

Researchers identified 13 plasma proteins linked to brain aging, uncovering dynamic patterns and biomarkers for early intervention in aging-related brain health.

10 Dec 2024

Scripps Research develops brain-inspired AI for real-time video analysis

Imagine an artificial intelligence (AI) model that can watch and understand moving images with the subtlety of a human brain.

9 Dec 2024

The brain’s hunger switch: TRH neurons hold the key to obesity therapies

Scientists uncover how TRH neurons suppress hunger by inhibiting AgRP neurons, advancing our understanding of GLP-1-based obesity treatments.

9 Dec 2024

Understanding how the skin's neurons process social touch signals

Two types of neurons in the skin may be particularly important for how the brain interprets social contact between people, according to a new study led by Linköping University in Sweden.

6 Dec 2024

Study: Brain volume changes correlate with social behavior differences in psychiatric conditions

A study published in Molecular Psychiatry found that brain volume changes correlate with social behavior differences in psychiatric conditions such as autism spectrum disorder and schizophrenia.

6 Dec 2024

Hypothalamic deep brain stimulation restores walking after spinal cord injury

Scientists have identified neurons in the lateral hypothalamus that can be targeted through deep brain stimulation to improve walking after spinal cord injury (SCI). This innovative approach shows promise in both animal models and initial human trials, paving the way for groundbreaking treatments.

2 Dec 2024

Study challenges long-standing understanding of axon structure

Biology textbooks may need a revision, say Johns Hopkins Medicine scientists, who present new evidence that an armlike structure of mammalian brain cells may be a different shape than scientists have assumed for more than a century.

2 Dec 2024

New model can explain neural and behavioral differences in autism spectrum disorder

Researchers Dr. Yuval Hart and Oded Wertheimer from the Psychology department and the Edmond and Lily Safra Center for Brain Science (ELSC) at The Hebrew University of Jerusalem have developed a new computational model to explain neural and behavioral differences in autism spectrum disorder.

28 Nov 2024