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The ability of antiviral formulation ViruSAL to inhibit SARS-CoV-2 infectivity

Researchers from Ireland used human bronchial epithelium models to evaluate the ability of a novel proprietary formulation called ViruSAL to inhibit SARS-CoV-2 infections.

12 Oct 2022

Researchers report the first RT-qPCR for simultaneous detection and discrimination of Omicron sub-variants

Researchers developed a RT-qPCR system to identify SARS-CoV-2 Omicron variants of concern.

12 Oct 2022

RNA-dependent RNA polymerase inhibitors in COVID-19 therapy

A new paper reviews current knowledge of RdRp inhibitors that could be developed further to provide broadly effective antivirals against SARS-CoV-2 in particular and CoVs in general.

10 Oct 2022

UMSOM researchers identify how multiple genes of SARS-CoV-2 affect disease severity

University of Maryland School of Medicine researchers have identified how multiple genes of SARS-CoV-2 affect disease severity, which could lead to new ways in how we develop future vaccines or develop newer treatments.

7 Oct 2022

Silver nanoparticle and polyurethane composite provides potential coating options to limit fomite transmission of SARS-CoV-2

In a new study, researchers synthesized and evaluated a silver and polyurethane nanocomposite surface coating material that exhibits antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

7 Oct 2022

Three-dimensional in vitro model to reproduce COVID-19-induced endothelial dysfunction

In a new study, researchers developed a three-dimensional (3D) in vitro tissue model to assess the effects of SARS-CoV-2 on the vascular endothelial cells.

5 Oct 2022

Key biophysical attributes of a self-amplifying viral RNA vaccine developed for SARS-CoV-2

Researchers used various analytical characterization techniques to determine the biophysical attributes of the Imperial College London self-amplifying viral RNA vaccine (IMP-1) developed for SARS-CoV-2.

5 Oct 2022

Study shows SARS-CoV-2 infects human adipose tissue and undergoes productive infection in fat cells

Researchers demonstrated infection of human adipose tissue by SARS-CoV-2.

5 Oct 2022

Antibody escape mutations of SARS-CoV-2 BA.2.75

A new study discusses how immune escape mutations allow a recent SARS-CoV-2 variant to evade neutralizing antibodies and cause breakthrough infections.

4 Oct 2022

What are the challenges of COVID-19 vaccination and herd immunity?

A new study reviewed the challenges of coronavirus disease 2019 (COVID-19) vaccination and herd immunity.

4 Oct 2022

Spike-specific memory B cells develop resilience to SARS-CoV-2

In a recent study posted to the bioRxiv* preprint server, researchers explored the cross-reactivity, avidity, and kinetics of memory B-cells and serum antibodies in vaccinated and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected individuals.

4 Oct 2022

How COVID-19 affects the female reproductive system

A new review in the Biology of Reproduction journal analyzed the relationship between the immune system and the female reproductive system while focusing on the effects of COVID-19-associated immune responses on the reproductive system. The study searched PubMed to identify peer-reviewed literature in English up to May 2022 and finally included 83 studies.

3 Oct 2022

A case for updating COVID vaccines with beta variant spike sequences

A recent Nature Communications study has discussed preclinical and clinical data on COVID-19 vaccine antigens that could be utilized to develop effective booster vaccines.

3 Oct 2022

Is it safe to breastfeed after the COVID-19 mRNA vaccination?

A recent study attempts to answer the question of whether the COVID-19 vaccine is safe for lactating women who received the vaccine within six months postpartum.

3 Oct 2022

Novel linear DNA SARS-CoV-2 vaccine using electroporation-aided vaccine delivery reveals lower viral shedding in ferrets

Researchers evaluated the efficacy, immunogenicity, and safety of a novel SARS-CoV-2 linear deoxyribonucleic acid vaccine in ferret models delivered using intramuscular injection and electroporation.

3 Oct 2022

Brazilian study reveals the effects of SARS-CoV-2 infection on the central nervous system

A Brazilian study published in the journal PNAS describes some of the effects infection by SARS-CoV-2 can have on the central nervous system.

30 Sep 2022

Simple nasal wash can prevent hospitalization and deaths from COVID-19

Simple nasal washes with mild saline water can prevent hospitalization and deaths from COVID-19, if applied twice daily following a positive diagnosis, according to research led by the US-based Augusta University.

30 Sep 2022

SARS-CoV-2 spike protein and messenger ribonucleic acid found to translocate into the nucleus

In a new study, researchers reported severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) spike (S) protein and S messenger ribonucleic acid (mRNA) nuclear co-translocation as a novel feature of SARS-CoV-2 pathogenesis.

30 Sep 2022

Bioactive compounds derived from Ganoderma lucidum exhibit anti-SARS-CoV-2 activity

Scientists have identified lucidenic acid A, one of the bioactive compounds of Ganoderma lucidum, as a potential inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) host cell entry. The study has recently been published in the journal Food and Chemical Toxicology.

29 Sep 2022

Exploring remdesivir resistance in COVID-19-infected transplant recipients

In a new study, researchers assessed the remdesivir resistance developed in coronavirus disease 2019 (COVID-19)-infected transplant recipients.

29 Sep 2022

Spike Protein News and Research

The ability of antiviral formulation ViruSAL to inhibit SARS-CoV-2 infectivity

Researchers report the first RT-qPCR for simultaneous detection and discrimination of Omicron sub-variants

RNA-dependent RNA polymerase inhibitors in COVID-19 therapy

UMSOM researchers identify how multiple genes of SARS-CoV-2 affect disease severity

Silver nanoparticle and polyurethane composite provides potential coating options to limit fomite transmission of SARS-CoV-2

Three-dimensional in vitro model to reproduce COVID-19-induced endothelial dysfunction

Key biophysical attributes of a self-amplifying viral RNA vaccine developed for SARS-CoV-2

Study shows SARS-CoV-2 infects human adipose tissue and undergoes productive infection in fat cells

Antibody escape mutations of SARS-CoV-2 BA.2.75

What are the challenges of COVID-19 vaccination and herd immunity?

Spike-specific memory B cells develop resilience to SARS-CoV-2

How COVID-19 affects the female reproductive system

A case for updating COVID vaccines with beta variant spike sequences

Is it safe to breastfeed after the COVID-19 mRNA vaccination?

Novel linear DNA SARS-CoV-2 vaccine using electroporation-aided vaccine delivery reveals lower viral shedding in ferrets

Brazilian study reveals the effects of SARS-CoV-2 infection on the central nervous system

Simple nasal wash can prevent hospitalization and deaths from COVID-19

SARS-CoV-2 spike protein and messenger ribonucleic acid found to translocate into the nucleus

Bioactive compounds derived from Ganoderma lucidum exhibit anti-SARS-CoV-2 activity

Exploring remdesivir resistance in COVID-19-infected transplant recipients

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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