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Antiviral immune response is suppressed in COVID-19 patients compared to flu patients

Rather than life-threatening hyperinflammation, most adults with moderate-to-severe COVID-19 have a suppressed viral immune response when compared to adults with another viral respiratory infection, influenza. St. Jude Children's Research Hospital and Washington University School of Medicine in St. Louis led research that suggests most COVID-19 patients are not candidates for treatment with steroids such as dexamethasone.

16 Nov 2020

Study explains why anti-inflammatory drugs benefit only few people with severe COVID-19

The turning point for people with COVID-19 typically comes in the second week of symptoms. As most people begin to recover, a few others find it increasingly difficult to breathe and wind up in the hospital.

16 Nov 2020

Elastic-free facial masks could benefit individuals with contact dermatitis during COVID-19

A University of Cincinnati immunologist is recommending that individuals with contact dermatitis choose facial masks made without elastic or rubber that allow them to stay safe in the midst of COVID-19 while avoiding possible allergic reactions.

15 Nov 2020

HSS presents research related to rheumatology and orthopedic surgery at 2020 ACR annual meeting

At this year's American College of Rheumatology virtual meeting, Hospital for Special Surgery (HSS) presented exciting research related to rheumatology and orthopedic surgery.

10 Nov 2020

Study shows dexamethasone can reduce chance of COVID-19-related death

Research has shown that dexamethasone, a widely available steroid, can significantly reduce the chance of death from COVID-19.

10 Nov 2020

Oral methotrexate can be an effective intervention for people with knee OA

A new study presented at ACR Convergence, the American College of Rheumatology's annual meeting, shows that after three months of treatment with oral methotrexate, adults with primary knee osteoarthritis (OA) with inflammation had significant improvements in physical function and inflammation, a sign that this inexpensive, generic pill may be an important intervention for knee OA.

6 Nov 2020

Study highlights racial disparities in the care of patients with rheumatoid arthritis

A new study reveals that Black patients with rheumatoid arthritis (RA) were less likely to be prescribed a biologic treatment and more likely to use glucocorticoids, which carry a risk of serious long-term side effects.

6 Nov 2020

Corticosteroid injections for knee OA do not speed up the progression of disease

New research shows that corticosteroid injections for knee OA treatment do not hasten a patient's progression to a total knee replacement when compared with hyaluronic acid injections.

6 Nov 2020

Researchers identify a new way to prevent skin reactions in cancer patients

Using the body's immune system to fight cancer has great potential, but can also bring serious side effects, including itchy and painful skin reactions.

27 Oct 2020

Antenatal steroids improve preterm newborn survival in low-resource settings, finds study

The results of a new clinical trial, published today in the New England Journal of Medicine, show that dexamethasone- a glucocorticoid used to treat many conditions, including rheumatic problems and severe COVID-19- can boost survival of premature babies when given to pregnant women at risk of preterm birth in low-resource settings.

23 Oct 2020

Study unravels consequences of mating at the molecular level

While it is known that stem cells have the ability to develop into all tissues in a precisely regulated process, the way environmental cues affect stem cell behavior has remained poorly understood.

21 Oct 2020

Conflicting evidence on potential benefit, negative outcomes of hip and knee steroid injections

Osteoarthritis of the hip and knee is among the most common joint disorders. A frequently performed treatment for osteoarthritis and other joint related pain syndromes are IACS, yet there is conflicting evidence on their potential benefit and possible negative outcomes following such injections.

20 Oct 2020

Androgen deprivation strategies could help mitigate SARS-CoV-2 infection

Since the beginning of the COVID-19 pandemic, researchers have noted that women are generally less severely affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This has led to the exploration into estrogen and androgens' role in the hyperinflammatory clinical phenotypes of COVID-19. A recent study published on the preprint server bioRxiv shows that drugs targeting androgens and TMPRSS2 inhibitors may potentially combat the pandemic.

20 Oct 2020

Immunoglobulin M ACE2 autoantibodies associated with severe COVID-19

As the COVID-19 pandemic progresses with little prospect of immediate relief, a recent study by Johns Hopkins University researchers published on the preprint server medRxiv* in October 2020 discusses the association of Immunoglobulin M (IgM) autoantibodies against the host receptor that binds severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with severe disease via vascular endothelial damage. This could help develop better therapies and prognostic criteria.

19 Oct 2020

Serum metabolite profile can help identify individuals at risk of alcohol-related disease

A new study from the University of Eastern Finland is the first in the world to show that the serum metabolite profile can be used to identify individuals likely at risk of developing an alcohol-related disease in the future.

19 Oct 2020

Comparative analysis reveals common vulnerabilities across coronaviruses

Three lethal human respiratory syndromes associated with coronavirus (CoV) infections have emerged in the past two decades. They are severe acute respiratory syndrome (SARS) in 2002, Middle East respiratory syndrome (MERS) in 2012, and coronavirus disease 2019 (COVID-19) in 2019.

18 Oct 2020

Steroid News and Research

Antiviral immune response is suppressed in COVID-19 patients compared to flu patients

Study explains why anti-inflammatory drugs benefit only few people with severe COVID-19

Elastic-free facial masks could benefit individuals with contact dermatitis during COVID-19

HSS presents research related to rheumatology and orthopedic surgery at 2020 ACR annual meeting

Study shows dexamethasone can reduce chance of COVID-19-related death

Oral methotrexate can be an effective intervention for people with knee OA

Study highlights racial disparities in the care of patients with rheumatoid arthritis

Corticosteroid injections for knee OA do not speed up the progression of disease

Researchers identify a new way to prevent skin reactions in cancer patients

Antenatal steroids improve preterm newborn survival in low-resource settings, finds study

Study unravels consequences of mating at the molecular level

Conflicting evidence on potential benefit, negative outcomes of hip and knee steroid injections

Androgen deprivation strategies could help mitigate SARS-CoV-2 infection

Immunoglobulin M ACE2 autoantibodies associated with severe COVID-19

Serum metabolite profile can help identify individuals at risk of alcohol-related disease

Comparative analysis reveals common vulnerabilities across coronaviruses

COVID-19 can cause sudden permanent hearing loss in rare cases

Engineered tissue grafts for temporomandibular joint regeneration

Scientists engineer tissue grafts for personalized joint replacement

Blood profile could help identify COVID-19 patients at greatest risk of deterioration

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Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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How Omics Technologies Are Transforming Biological Research and Drug Discovery

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