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Trained immunity: its role in COVID-19 and potential in preparing for future infectious outbreaks

Researchers reported on the contribution of trained immune responses to protection against SARS-CoV-2 infections and future pandemics.

16 Jun 2023

Aging impacts cellular composition across the whole fly: Study

As the body ages, organ function progressively declines and the risk for a wide range of diseases, including cardiovascular disease, cancer and neurodegenerative diseases, increases. Understanding how the body ages is an intense area of research as it will potentially illuminate ways to promote healthy aging.

16 Jun 2023

New method offers insights into mechanisms of staphylococcal pathogenesis

Nearly one in three people globally unknowingly carries Golden staph, or Staphylococcus aureus, in their nose or on their skin. While the bacterium is harmless to most, it can lead to serious infection and even death if it enters the bloodstream through a cut, surgical wound or catheter.

16 Jun 2023

Penn research bolsters scientific understanding behind why some people are more prone to allergies

New research is bolstering scientific understanding behind why some people are more prone to allergies than others.

15 Jun 2023

Destroying the tether of shattered chromosomal fragments may help prevent cancerous mutations

Healthy cells work hard to maintain the integrity of our DNA, but occasionally, a chromosome can get separated from the others and break apart during cell division.

15 Jun 2023

Innovative method to map specific DNA markings could be used for early cancer detection

Researchers from the Perelman School of Medicine at the University of Pennsylvania have invented a new way to map specific DNA markings called 5-methylcytosine (5mC) which regulate gene expression and have key roles in health and disease.

15 Jun 2023

New approach improves diagnosis of limb-girdle muscular dystrophy

It's not easy to distinguish between the dozens of subtypes of limb girdle muscular dystrophy - a rare, genetic muscle disease characterized by weakness in the hips and shoulders that causes difficulty walking and lifting the arms.

15 Jun 2023

COVID-19 susceptibility mechanism discovered using a newly created tool

Researchers have discovered a mechanism for COVID-19 susceptibility using a newly created tool. The tool, GASPACHO, captures dynamic changes in gene expression along the innate immune response, allowing researchers to identify genes and molecular pathways associated with disease risk that have previously been too complex to detect or interpret.

15 Jun 2023

Insilico announces new multimodal transformer-based aging clock for processing diverse data sets

Clinical stage generative artificial intelligence (AI)-driven drug discovery company Insilico Medicine ("Insilico") has announced a new multimodal transformer-based aging clock that is capable of processing diverse data sets and providing insights into biomarkers for aging, mapping them to genes relevant to both aging and disease, and discovering new therapeutic targets designed to slow or reverse both aging and aging-related diseases.

15 Jun 2023

New findings expand the genotypic spectrum of NPRL3-associated focal epilepsy

Science China Life Sciences magazine recently reported on the research results of Tang Beisha's team from Xiangya Hospital of Central South University, Liu Jing Yu's team from the Institute of Neurology of the Chinese Academy of Sciences, and Zhang Luoying's team from Huazhong University of Science and Technology, including Du Shiyue, Zeng Sheng, and Song Li. Epilepsy has a complex etiology with 80% owing a genetic basis.

15 Jun 2023

Mapping the evolutionary timeline and population distribution of E. coli’s protective outer capsule

In a new study, published today (15 June) in Nature Communications, a multi-centre team led by the Wellcome Sanger Institute, the University of Oslo, Imperial College London and UCL, has mapped for the first time the evolutionary timeline and population distribution of Escherichia coli’s protective outer capsule, which is responsible for the bacterium’s virulence.

15 Jun 2023

Study reveals a co-pathogenesis mechanism of acute myocardial infarction and ulcerative colitis

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Cardiovascular diseases, particularly acute myocardial infarction, are the leading cause of disability and death.

15 Jun 2023

Unlocking the secret to lifelong health: the power of optimal immune resilience

Researchers assessed immune resilience (IR) metrics in individuals across diverse infectious and non-infectious models.

15 Jun 2023

Study reports outbreak of C. vulturna in a hospital in China

Researchers reported an increase in Candida vulturna infections among residents of China between 2019 and 2022.

15 Jun 2023

New base-edited T-cells proven effective to treat lymphoblastic leukemia

Three young patients with relapsed T-cell leukemia have now been treated with base-edited T-cells, as part of a 'bench-to-bedside' collaboration between UCL and Great Ormond Street Hospital for Children (GOSH).

15 Jun 2023

New method of insulin delivery lowers the risk of hypoglycemia compared to current diabetes treatments

Insulin production has, for the last 50 or so years, come with some risks to the patient. Even so, the medication is lifesaving for the estimated 537 million adults living with diabetes worldwide, with that number expected to grow.

15 Jun 2023

Scientists identify major mechanism behind the transition between chronic and acute bacterial infections

People with weakened immune systems are at constant risk of infection. Pseudomonas aeruginosa, a common environmental bacterium, can colonize different body parts, such as the lungs, leading to persistent, chronic infections that can last a lifetime – a common occurrence in people with cystic fibrosis.

14 Jun 2023

Mutations that lead to intracranial aneurysms discovered

Researchers at the RIKEN Center for Brain Science (CBS) in Japan have discovered a set of related mutations that lead to intracranial aneurysms - weakened blood vessels in the brain that can burst at any time.

14 Jun 2023

CrossDome tool helps predict the potential risks of T-cell immunotherapy

Researchers at the University of Houston are working to make T-cell immunotherapy safer, developing a tool called CrossDome, which uses a combination of genetic and biochemical information to predict if T-cell immunotherapies might mistakenly attack healthy cells.

14 Jun 2023

Inflammation regulating gene also plays a key role in maintaining normal blood-sugar levels, study shows

A study led by researchers at the Garvan Institute of Medical Research shows for the first time how a gene called RELA, known to regulate inflammation, also plays an essential role in maintaining normal blood-sugar levels.

14 Jun 2023

Genes News and Research

Trained immunity: its role in COVID-19 and potential in preparing for future infectious outbreaks

Aging impacts cellular composition across the whole fly: Study

New method offers insights into mechanisms of staphylococcal pathogenesis

Penn research bolsters scientific understanding behind why some people are more prone to allergies

Destroying the tether of shattered chromosomal fragments may help prevent cancerous mutations

Innovative method to map specific DNA markings could be used for early cancer detection

New approach improves diagnosis of limb-girdle muscular dystrophy

COVID-19 susceptibility mechanism discovered using a newly created tool

Insilico announces new multimodal transformer-based aging clock for processing diverse data sets

New findings expand the genotypic spectrum of NPRL3-associated focal epilepsy

Mapping the evolutionary timeline and population distribution of E. coli’s protective outer capsule

Study reveals a co-pathogenesis mechanism of acute myocardial infarction and ulcerative colitis

Unlocking the secret to lifelong health: the power of optimal immune resilience

Study reports outbreak of C. vulturna in a hospital in China

New base-edited T-cells proven effective to treat lymphoblastic leukemia

New method of insulin delivery lowers the risk of hypoglycemia compared to current diabetes treatments

Scientists identify major mechanism behind the transition between chronic and acute bacterial infections

Mutations that lead to intracranial aneurysms discovered

CrossDome tool helps predict the potential risks of T-cell immunotherapy

Inflammation regulating gene also plays a key role in maintaining normal blood-sugar levels, study shows

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