Protein C News and Research

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Researchers discover PPFIA3 gene as a cause of previously unknown syndromic neurodevelopmental disorder

An international collaborative study led by postdoctoral scientist, Dr. Maimuna Paul, and child neurologist, Dr. Hsiao-Tuan Chao, an assistant professor at Baylor College, a faculty member with the Cain Pediatric Neurology Research Foundation Laboratories at the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children's Hospital, and an investigator at the McNair Medical Institute with The Robert and Janice McNair Foundation, recently discovered that variants in the PPFIA3 gene cause a previously unknown syndromic neurodevelopmental disorder.

4 Jan 2024

High-resolution map of the neuroblastoma immune landscape points to new target for immunotherapy

A detailed 'atlas' of neuroblastoma tumors points to a new target for immunotherapy. Scientists from the Princess Máxima Center for Pediatric Oncology in the Netherlands mapped this childhood tumor at the level of individual cancer and immune cells.

4 Jan 2024

Novel approach to de novo protein design enables creation of diverse functional structures

A team of researchers has developed an innovative method to design complicated all-α proteins, characterized by their non-uniformly arranged α-helices as seen in hemoglobin.

4 Jan 2024

Revolutionary RNA-based switch offers new control over gene expression in mammalian cells

Researchers developed an RNA-based switch, the pA regulator system, to control gene expression in mammalian cells by modulating synthetic polyA signal cleavage, offering a novel approach for gene therapy applications.

4 Jan 2024

AI model predicts future spread of SARS-CoV-2 variants using genomic data

Researchers developed an AI-based model to predict the spread of new SARS-CoV-2 variants, analyzing nine million genomic sequences across 30 countries and incorporating factors like vaccination rates and non-pharmaceutical interventions.

4 Jan 2024

Early-acting autophagy genes extend lifespan through alternative "garbage disposal" pathway in neurons

Autophagy, which declines with age, may hold more mysteries than researchers previously suspected. In the January 4th issue of Nature Aging, it was noted that scientists from the Buck Institute, Sanford Burnham Prebys and Rutgers University have uncovered possible novel functions for various autophagy genes, which may control different forms of disposal including misfolded proteins - and ultimately affect aging.

4 Jan 2024

Researchers develop peptide to target "chaotic" MYC protein in 75% of cancers

Meet MYC, the shapeless protein responsible for making the majority of human cancer cases worse.

4 Jan 2024

Salk scientists map brain circuit triggering the crippling panic attacks

Overwhelming fear, sweaty palms, shortness of breath, rapid heart rate - these are the symptoms of a panic attack, which people with panic disorder have frequently and unexpectedly.

4 Jan 2024

Gut microbiome plays a role in immune response to mRNA COVID vaccines

Researchers from Karolinska Institutet in Sweden have discovered that the gut microbiome can influence how well people respond to mRNA COVID vaccines.

4 Jan 2024

IDO2 deficiency in mice leads to behavioral abnormalities resembling autism spectrum disorder

Over the past decades, scientists have made substantial progress unveiling the underlying mechanisms behind many psychiatric disorders.

4 Jan 2024

Could your diet impact endometriosis? Research points to dietary insights for treatment

The role of dietary ingredients in modifying the progression and development of endometriosis.

4 Jan 2024

Study finds previously unidentified genetic mutation in a small protein provides significant protection against Parkinson’s disease

Researchers explored the effects of a small humanin-like peptide 2 (SHLP2) variant on mitochondrial function.

4 Jan 2024

New compound effective against bacterial species resistant to multiple classes of existing antibiotics

Recent studies by Zampaloni et al. and Pahil et al. published in the journal Nature describe a novel method of inhibiting the growth of Gram-negative bacteria such as Acinetobacter using antibiotics consisting of macrocyclic peptides that target the bacterial protein bridge machinery that transports lipopolysaccharides from the cytoplasm to the outer membrane.

4 Jan 2024

Missing proteins explain century-old mystery of scalp skin absence in children

Children with the condition aplasia cutis congenita (ACC) are born with the absence of skin along the midline of the scalp.

3 Jan 2024

EZH2 inhibitors show promise in regenerating insulin-producing cells for type 1 diabetes treatment

Study explores the potential of EZH2 inhibitors GSK126 and Tazemetostat in stimulating β-cell regeneration from pancreatic ductal progenitor cells, offering a novel therapeutic approach for Type 1 Diabetes.

3 Jan 2024

Research could offer a new approach to treating malnourished, stunted kids

Millions of children in under-resourced parts of the world suffer from malnutrition and, consequently, stunted growth.

3 Jan 2024

New method illuminates intricate interactions of the synaptonemal complex in nematodes

We have two copies of each chromosome in every cell in our bodies except in our reproductive cells. Sperm and egg cells contain a single copy of each chromosome with a unique mix of genes from our parents, an evolutionary trick to give our offspring genetic variability.

3 Jan 2024

Human vs. cow's milk fortifier in preterm infants: No significant outcome difference, study finds

Study compares the effects of feeding extremely preterm infants with human milk fortified with either human milk-based fortifier (HMBF) or cow's milk-based fortifier (BMBF), finding no significant difference in the incidence of necrotizing enterocolitis, sepsis, or death.

3 Jan 2024

Eastern equine encephalitis virus study uncovers decoy molecule that protects against deadly brain infection

An atomic-level investigation of how Eastern equine encephalitis virus binds to a key receptor and gets inside of cells also has enabled the discovery of a decoy molecule that protects against the potentially deadly brain infection, in mice.

3 Jan 2024

MGH study identifies key proteins linked to pregnancy hypertension disorders

Preeclampsia and other hypertensive disorders of pregnancy - which are characterized by high blood pressure with or without organ dysfunction during the second half of pregnancy - carry considerable short- and long-term risks for both the mother and child. Treatment options (other than expedited delivery) remain limited.

3 Jan 2024

Protein C News and Research

Researchers discover PPFIA3 gene as a cause of previously unknown syndromic neurodevelopmental disorder

High-resolution map of the neuroblastoma immune landscape points to new target for immunotherapy

Novel approach to de novo protein design enables creation of diverse functional structures

Revolutionary RNA-based switch offers new control over gene expression in mammalian cells

AI model predicts future spread of SARS-CoV-2 variants using genomic data

Early-acting autophagy genes extend lifespan through alternative "garbage disposal" pathway in neurons

Researchers develop peptide to target "chaotic" MYC protein in 75% of cancers

Salk scientists map brain circuit triggering the crippling panic attacks

Gut microbiome plays a role in immune response to mRNA COVID vaccines

IDO2 deficiency in mice leads to behavioral abnormalities resembling autism spectrum disorder

Could your diet impact endometriosis? Research points to dietary insights for treatment

Study finds previously unidentified genetic mutation in a small protein provides significant protection against Parkinson’s disease

New compound effective against bacterial species resistant to multiple classes of existing antibiotics

Missing proteins explain century-old mystery of scalp skin absence in children

EZH2 inhibitors show promise in regenerating insulin-producing cells for type 1 diabetes treatment

Research could offer a new approach to treating malnourished, stunted kids

New method illuminates intricate interactions of the synaptonemal complex in nematodes

Human vs. cow's milk fortifier in preterm infants: No significant outcome difference, study finds

Eastern equine encephalitis virus study uncovers decoy molecule that protects against deadly brain infection

MGH study identifies key proteins linked to pregnancy hypertension disorders

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