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New AI tool predicts viral mutations to help future-proof COVID vaccines

A novel AI-driven method helps scientists stay ahead of viral evolution by engineering synthetic spike proteins that anticipate future SARS-CoV-2 escape mutations, offering a powerful tool to test and strengthen next-generation vaccines.

11 May 2025

New human ovaroid model offers insight into infertility and differences in sex development

A new model of tiny human ovary organoids, or ovaroids, has been developed from stem cells, according to research presented at the first Joint Congress between the European Society of Paediatric Endocrinology (ESPE) and the European Society of Endocrinology (ESE).

11 May 2025

Blocking LSD1 restores immune response in early oral cancer

Oral squamous cell carcinoma (OSCC) is a leading cause of cancer-related deaths, and early detection is key to improving patient outcomes. However, the mechanisms driving the transition from preneoplastic lesions to full-blown cancer are not well understood.

11 May 2025

DNA strand separation requires more force in crowded cellular environments

By creating a more true-to-life representation of DNA's environment, researchers at Northwestern University have discovered that strand separation - the essential process a "resting" double helix undergoes before it can initiate replication or make repairs - may take more mechanical force than the field previously believed.

11 May 2025

Newly identified gene mutation causes severe form of Fanconi anemia

Fanconi anemia is an aggressive, life-threatening disorder. Most individuals living with this rare genetic condition, characterized by bone marrow failure and cancer predisposition, survive into adulthood only with bone marrow transplantation and regular cancer screening.

11 May 2025

Targeting METTL3 may offer new hope for oral cancer treatment

A new research paper was published in Oncotarget, Volume 16, on May 8, 2025, titled "METTL3 promotes oral squamous cell carcinoma by regulating miR-146a-5p/SMAD4 axis."

11 May 2025

Study reveals colonic inflammation as the trigger for beta cell growth in obesity

Researchers at the Tohoku University Graduate School of Medicine have uncovered a key primary step in the hepatic ERK pathway that leads to increased insulin production.

9 May 2025

Oxford study reveals how COVID-19 vaccines prevent severe illness

A landmark study by scientists at the University of Oxford, has unveiled crucial insights into the way that COVID-19 vaccines mitigate severe illness in those who have been vaccinated.

9 May 2025

Most of today’s children could endure historic heatwaves as planet warms

A Nature study projects that millions born after 1960 will face unprecedented lifetime exposure (ULE) to climate extremes, such as heatwaves, droughts, and floods. The risks grow with global warming and disproportionately impact socioeconomically vulnerable populations.

8 May 2025

MicroRNA breakthrough offers hope for dental bone regeneration

Dental caries, or tooth decay, is a common oral health condition that often causes significant pain and discomfort and may even lead to tooth loss.

8 May 2025

Why your baby’s first steps may be written in their DNA

Researchers identified 11 genetic loci linked to the age at which infants start walking, revealing that this milestone is influenced by thousands of common genetic variants. These genetic factors also correlate with brain development, cognitive traits, and neurodevelopmental conditions like ADHD.

8 May 2025

Annual blood test could detect cancer earlier and save lives

A single blood test, designed to pick up chemical signals indicative of the presence of many different types of cancer, could potentially thwart progression to advanced disease while the malignancy is still at an early stage and amenable to treatment in up to half of cases, suggests a modelling study published in the open access journal BMJ Open.

8 May 2025

St. Jude Children's scientists use brain organoids to study rare encephalopathy

While extremely rare, encephalopathy (a condition affecting brain function) triggered by mutations in the UBA5 gene has devastating impacts, with affected individuals reaching few developmental milestones and experiencing frequent and early-onset seizures.

8 May 2025

Vitamin supplement slows glaucoma progression in animal studies

A vitamin supplement that improves metabolism in the eye appears to slow down damage to the optic nerve in glaucoma.

8 May 2025

Mature liver cells trigger regeneration in response to neighboring injury

Acetaminophen is the most frequently taken fever and pain medication worldwide, but overdosing can be toxic to liver cells. In the United States, about 1,600 cases of acute liver failure and 500 deaths occur each year due to acetaminophen overuse and liver failure.

8 May 2025

New stem cell model mimics alpha cell behavior in diabetic conditions

Mor than 800 million people worldwide are living with diabetes, according to World Health Organization (WHO) estimates, with numbers steadily increasing.

8 May 2025

New immunotherapy target found in pancreatic cancer cells

Researchers from MIT and Dana-Farber Cancer Institute have discovered that a class of peptides expressed in pancreatic cancer cells could be a promising target for T-cell therapies and other approaches that attack pancreatic tumors.

8 May 2025

Wildlife trade, not bats, likely moved the ancestors of SARS-CoV-2 to humans

New genetic analyses reveal that the bat virus ancestors of SARS-CoV-1 and SARS-CoV-2 likely circulated in Western China or Northern Laos just years before human outbreaks. Their rapid appearance thousands of kilometers away suggests wildlife trade, not bat migration, was the likely transmission path.

8 May 2025

Eating avocado in pregnancy cuts infant food allergy risk by nearly half

Pregnant women who ate avocado were significantly less likely to have children with food allergies at 12 months of age. The association held even after adjusting for maternal diet quality, lifestyle, and perinatal factors in a large Finnish cohort.

8 May 2025

Cancer rates are climbing in younger adults and researchers want to know why

A new NIH-led study finds rising rates of 14 cancer types in Americans under 50, especially breast, colorectal, kidney, uterine, and pancreatic cancers. The research urges deeper investigation into shared risk factors and earlier screening strategies.

8 May 2025