Clinical Trial News and Research

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Removing high-grade squamous intraepithelial lesions reduces chances of progression to anal cancer

In a randomized clinical trial with 4,446 participants, known as the Anal Cancer/HSIL Outcomes Research (ANCHOR) study, researchers found that by removing high-grade squamous intraepithelial lesions (HSIL), chances of progression to anal cancer were significantly reduced.

8 Oct 2021

Novel peptide-drug conjugate enhances the efficacy of immunotherapy in preclinical cancer models

A peptide-drug conjugate that targets the acidic environment of cancer cells enhanced the efficacy of immune checkpoint inhibitors in preclinical cancer models, according to results presented at the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics, held October 7-10, 2021.

7 Oct 2021

Study uncovers new drug target for myelodysplastic syndrome

Mount Sinai and UC San Diego researchers have shown for the first time how mutations affecting a cellular process called RNA splicing alter cells to develop myelodysplastic syndrome (MDS) and other hematologic malignancies and solid tumors, according to a study published in Cancer Discovery in October.

7 Oct 2021

Study sheds light on the beneficial effects of peanut consumption in young and healthy people

A study published in the journal Clinical Nutrition provides new knowledge on the health effects of a diet rich in nuts.

7 Oct 2021

Deadly subtype of T-cell lymphoma harbors unique mutations

An especially deadly subtype of T-cell lymphoma is distinguished by unique mutations in a specific protein signaling pathway, according to a study published in the journal Blood.

7 Oct 2021

Critical function of IL-7 in diagnosis, prognosis, and treatment of COVID-19 patients

In this review, researchers summarized the therapeutic and pathogenic role of IL-7 in patients with COVID-19 and examined the promising role of IL-7 as a vaccine adjuvant.

7 Oct 2021

Australian researchers hope to switch on sight with new gene therapy

Australian researchers are developing a new gene therapy which they hope will ‘switch on sight’ by regenerating light-sensing photoreceptor cells in the retina at the back of the eye.

7 Oct 2021

Scientists identify a new method to treat triple-negative breast cancer

A team of clinicians and scientists from the National Cancer Centre Singapore (NCCS), Singapore General Hospital (SGH) and A*STAR's Genome Institute of Singapore (GIS) has identified a novel method to treat triple-negative breast cancer (TNBC). They discovered that cancer cells switch between different cell states and are able to change from being less aggressive ('epithelial') to being more aggressive ('mesenchymal'), and vice versa.

7 Oct 2021

Pancreatic cancer clinical trials exclude Black patients based on wide range of eligibility criteria

A simulated pancreatic cancer clinical trial screening process showed that Black patients were significantly more likely than white patients to be excluded from clinical trials for a wide range of eligibility criteria, according to results presented at the virtual 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held October 6-8, 2021.

6 Oct 2021

COVID-19 vaccine clinical trial for children is underway in St. Louis

A pediatric COVID-19 vaccine clinical trial is underway in St. Louis. Led by Washington University School of Medicine, about 140 area children will receive the two-shot Moderna vaccine or placebo at St. Louis Children's Hospital as part of a clinical trial involving about 100 medical institutions in the U.S. and Canada.

6 Oct 2021

Elevated allostatic load may impact treatment completion and breast cancer survival outcomes

Elevated allostatic load was associated with a lower likelihood of completing chemotherapy and a lower overall survival rate in patients with lymph node-positive or high-risk lymph node-negative HER2-negative breast cancer, according to results presented at the 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held online October 6-8, 2021.

6 Oct 2021

Video game with biofeedback trains kids to stay calm during stressful or frustrating situations

A video game with biofeedback - aimed at keeping heart rate low during fast-paced play - can help youth learn to regulate their anger, finds a small randomized trial at Boston Children's Hospital.

5 Oct 2021

AstraZeneca COVID-19 vaccine safe and effective in phase 3 U.S., Chile, and Peru trial

A new study reports on the results of phase III clinical trial on the safety and efficacy of the AstraZeneca-Oxford COVID-19 vaccine.

5 Oct 2021

Structural differences in the brain may explain why siblings differ in risk of developing conduct disorder

Structural differences in the area of the brain responsible for decision making could explain why two siblings living in the same family might differ in their risk of developing the condition conduct disorder.

5 Oct 2021

Racism a strong factor in Black women’s high rate of premature births, study finds

The tipping point for Dr. Paula Braveman came when a longtime patient of hers at a community clinic in San Francisco's Mission District slipped past the front desk and knocked on her office door to say goodbye. He wouldn't be coming to the clinic anymore, he told her, because he could no longer afford it.

5 Oct 2021

Convalescent plasma is "futile" as COVID-19 treatment for critically ill patients, trial shows

In the earliest days of the COVID-19 pandemic, the medical community turned to a century-old treatment: Take blood from recovered patients and give it to the sick.

4 Oct 2021

REGEN-COV shown to reduce risk of COVID-19–related hospitalization or death from any cause

The phase 1-2 clinical trials conducted using REGEN-COV had shown promising therapeutic benefits in COVID-19 outpatients. Its effect was further investigated in the present phase 3 clinical trial, the findings of which have been published in the "The New England Journal of Medicine".

3 Oct 2021

Northwestern’s SPORE has made advances in understanding the genetic basis of glioblastoma

Glioblastoma is one of the deadliest cancers known to man. While the advent of immunotherapy and other cutting-edge treatments have prolonged life for people afflicted with other types of cancer, the prognosis for glioblastoma has remained relatively constant: just 18 months.

3 Oct 2021

Scientists identify potential treatment for previously unknown condition affecting children

Researchers from the Agency for Science, Technology and Research's (A*STAR) Genome Institute of Singapore (GIS), and Rady Children's Institute for Genomic Medicine identified a previously unknown condition affecting children, which they discovered could be prevented by administering a drug during pregnancy.

2 Oct 2021

Research on wandering thoughts may offer clues about mental health

Where does your mind wander when you have idle time? A University of Arizona-led study published in Scientific Reports may offer some clues, and the findings reveal a surprising amount about our mental health.

2 Oct 2021

Clinical Trial News and Research

Removing high-grade squamous intraepithelial lesions reduces chances of progression to anal cancer

Novel peptide-drug conjugate enhances the efficacy of immunotherapy in preclinical cancer models

Study uncovers new drug target for myelodysplastic syndrome

Study sheds light on the beneficial effects of peanut consumption in young and healthy people

Deadly subtype of T-cell lymphoma harbors unique mutations

Critical function of IL-7 in diagnosis, prognosis, and treatment of COVID-19 patients

Australian researchers hope to switch on sight with new gene therapy

Scientists identify a new method to treat triple-negative breast cancer

Pancreatic cancer clinical trials exclude Black patients based on wide range of eligibility criteria

COVID-19 vaccine clinical trial for children is underway in St. Louis

Elevated allostatic load may impact treatment completion and breast cancer survival outcomes

Video game with biofeedback trains kids to stay calm during stressful or frustrating situations

AstraZeneca COVID-19 vaccine safe and effective in phase 3 U.S., Chile, and Peru trial

Structural differences in the brain may explain why siblings differ in risk of developing conduct disorder

Racism a strong factor in Black women’s high rate of premature births, study finds

Convalescent plasma is "futile" as COVID-19 treatment for critically ill patients, trial shows

REGEN-COV shown to reduce risk of COVID-19–related hospitalization or death from any cause

Northwestern’s SPORE has made advances in understanding the genetic basis of glioblastoma

Scientists identify potential treatment for previously unknown condition affecting children

Research on wandering thoughts may offer clues about mental health

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