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Stabilizing dysfunctional endothelial cells reverses cellular dysfunction in rat model of SVD

Researchers have discovered that stabilizing dysfunctional endothelial cells with approved drugs reverses cellular dysfunction in a rat model of cerebral small vessel disease, hinting towards a new therapeutic approach for the treatment of vascular dementia.

5 Jul 2018

Study explores impact of surgeons on genetic testing in breast cancer patients

For many women diagnosed with breast cancer, genetic testing can offer important information that might guide treatment choices. But studies have shown that only about half of women who could benefit receive genetic testing.

4 Jul 2018

Study does not find causal association between assisted reproduction and ovarian cancer risk

Following concerns over many years that hormonal stimulation of the ovaries necessary for IVF may increase the risk of ovarian cancer, a nationwide cohort study from Denmark has now concluded that any perceived increase in risk is actually a statistical bias resulting from vigilant diagnosis at the time of treatment.

3 Jul 2018

Scientists develop new understanding of how psychiatric diseases manifest and can be treated

Research scientists from The Feinstein Institute for Medical Research and the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell in Hempstead, NY, in conjunction with their colleagues at Rockefeller University in New York City, have developed a new understanding of how certain psychiatric diseases - those that involve uncontrollable reactions to stimuli such as the high and low experiences attributed to bi-polar disorder, the impulsivity of an individual suffering from attention deficit hyperactivity disorder, and even suicidality - manifest and potentially can be treated. These findings were published today in Proceedings of the National Academy of Sciences.

3 Jul 2018

Researchers identify molecular mechanism leading to cortical malformation from brain-only mutations

Focal malformations of cortical development are a heterogeneous group of brain cortical abnormalities.

2 Jul 2018

PMDA approves use of LYNPARZA in patients with BRCA-mutated breast cancer

AstraZeneca and Merck, known as MSD outside the United States and Canada, today announced that Japan's Pharmaceuticals and Medical Devices Agency has approved LYNPARZA tablets for use in patients with unresectable or recurrent BRCA-mutated, human epidermal growth factor receptor 2 -negative breast cancer who have received prior chemotherapy.

2 Jul 2018

Enzyme TLK2 could serve as potential therapies for breast cancer, brain condition

In recent years, researchers have focussed on the enzyme TLK2 suspecting it of playing a main role in several diseases.

30 Jun 2018

Children's Colorado participates in cystic fibrosis triple combination therapy trials

Children's Hospital Colorado has announced that its Mike McMorris Cystic Fibrosis Research and Care Center, one of the largest cystic fibrosis clinical care centers in the U.S., is participating in one of two Phase Three clinical trials related to the development of a possible breakthrough therapy for people with CF.

29 Jun 2018

Hearing partially restored in deaf lab mice using novel therapy

A small molecule of a drug has been successfully used to treat an inherited form of hearing loss in laboratory mice.

28 Jun 2018

Genetic biomarker can help predict survival outcomes in patients with certain gliomas

A DNA-level biomarker (MGMT promoter methylation) can be used to help predict survival outcomes in patients with high-risk, low-grade gliomas, according to a new study conducted through the NRG Oncology/RTOG collaborative clinical trials group and led by scientists at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

28 Jun 2018

DNA methylation predicts survival outcome in patients with glioma

A new study has shown that survival rates among patients with glioma double if the tumor carries a methylated MGMT gene.

28 Jun 2018

Researchers show how mutant CALR protein triggers cancer

Researchers at Juntendo University report in the journal Leukemia how mutants of the protein calreticulin lead to molecular mechanisms triggering myeloproliferative neoplasms, which can cause cancer. The findings may lead to the development of novel therapies for certain types of blood cancer.

28 Jun 2018

Study provides insight into development of autism in the human brain

In a study published in Stem Cell Reports, a McGill team of scientists led by Dr. Carl Ernst, researcher at the Douglas Hospital Research Centre, revealed a molecular mechanism that may play a role in the development of autism.

27 Jun 2018

Researchers examine new influenza drug's mode of action in detail

The new influenza drug Xofluza, developed by the Japanese pharmaceutical company Shionogi, was approved for clinical use in Japan in February 2018.

26 Jun 2018

MIT researchers decode structure of molecule that gives tissues their elasticity

The stretchiness that allows living tissues to expand, contract, stretch, and bend throughout a lifetime is the result of a protein molecule called tropoelastin. Remarkably, this molecule can be stretched to eight times its length and always returns back to its original size.

26 Jun 2018

Researchers identify novel mutation in amyloid diseases

Researchers have identified a one-of-a kind mutation in the DNA of a patient who died of transthyretin (TTR) amyloidosis, a progressive condition characterized by the buildup of abnormal deposits of a misfolded protein called amyloid in the body's organs and tissues.

26 Jun 2018

Researchers work on new treatment that could improve lives of cystic fibrosis patients

Researchers at Oregon State University and Oregon Health & Science University are working on a treatment that holds great promise for improving the lives of cystic fibrosis patients.

25 Jun 2018

Genetic subset of prostate cancer may benefit from combination checkpoint immunotherapy

Researchers at the Johns Hopkins Kimmel Cancer Center and the Bloomberg~Kimmel Institute for Cancer Immunotherapy released a study investigating the use of combination checkpoint immunotherapy in the treatment of a lethal form of advanced prostate cancer.

25 Jun 2018

Study: Inner nuclear envelope plays role in lipid metabolism

The cell nucleus is an organelle, in which the DNA of an organism is protected and duplicated. The nucleus of this organ-like structure in the cell plasma is surrounded by an outer and an inner nuclear envelope, which is penetrated by openings - so-called nuclear pores.

22 Jun 2018

Harnessing Pediatric Cancer Genomic Data in the Cloud

Dr. Jinghui Zhang, an esteemed computational biologist at St. Jude Children's Research Hospital discusses her latest study and how technology such as cloud computing is changing the way that scientists carry out research.

21 Jun 2018

Mutation News and Research

Stabilizing dysfunctional endothelial cells reverses cellular dysfunction in rat model of SVD

Study explores impact of surgeons on genetic testing in breast cancer patients

Study does not find causal association between assisted reproduction and ovarian cancer risk

Scientists develop new understanding of how psychiatric diseases manifest and can be treated

Researchers identify molecular mechanism leading to cortical malformation from brain-only mutations

PMDA approves use of LYNPARZA in patients with BRCA-mutated breast cancer

Enzyme TLK2 could serve as potential therapies for breast cancer, brain condition

Children's Colorado participates in cystic fibrosis triple combination therapy trials

Hearing partially restored in deaf lab mice using novel therapy

Genetic biomarker can help predict survival outcomes in patients with certain gliomas

DNA methylation predicts survival outcome in patients with glioma

Researchers show how mutant CALR protein triggers cancer

Study provides insight into development of autism in the human brain

Researchers examine new influenza drug's mode of action in detail

MIT researchers decode structure of molecule that gives tissues their elasticity

Researchers identify novel mutation in amyloid diseases

Researchers work on new treatment that could improve lives of cystic fibrosis patients

Genetic subset of prostate cancer may benefit from combination checkpoint immunotherapy

Study: Inner nuclear envelope plays role in lipid metabolism

Harnessing Pediatric Cancer Genomic Data in the Cloud

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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