Genome News and Research

RSS

CD8+ T cells show gene-dependent variation in cross-reactivity to human coronaviruses

A new study discusses how both different responses to the infection itself and to COVID-19 vaccines are likely the result of genetic differences.

25 Jul 2021

Variations in human ACE2 genetics associated with coronavirus susceptibility

In a recent study, the researchers sought to understand the genetic variability in ACE2 that may contribute to inconsistent clinical outcomes of COVID-19.

25 Jul 2021

Study brings scientists one step closer to solving the mystery of aging

The human body is essentially made up of trillions of living cells. It ages as its cells age, which happens when those cells eventually stop replicating and dividing.

23 Jul 2021

Researchers use mass spectrometry to study immunogenic SARS-CoV-2 epitopes

A new study has been published on the bioRxiv* preprint server, which has used MS to identify T cell epitopes of SARS-CoV-2 conserved protein, i.e., the membrane glycol protein (MGP) and the non-structure protein-13 (NSP13).

23 Jul 2021

Clinical trials during a pandemic – lessons from COVID-19

In this interview, Dr. Benedicte Roquebert, Dr. Stephanie Haim-Boukobza and Dr. Souad Mehlal discuss how COVID-19 has resulted in new ways to think about clinical trials during a pandemic.

From Cerba Research 23 Jul 2021

Researchers develop a transferrable and integrative type I CRISPR-based platform to edit superbugs

A research team led by Dr Aixin YAN, Associate Professor from the Research Division for Molecular & Cell Biology, Faculty of Science, in collaboration with Honorary Clinical Professor Patrick CY WOO from the Department of Microbiology, Li Ka Shing Faculty of Medicine, the University of Hong Kong, reported the development of a transferrable and integrative type I CRISPR-based platform.

23 Jul 2021

Researchers identify an unexpected effect for already characterized active substances

Every innovative drug starts with the search for an active substance targeting key players in disease-related processes.

23 Jul 2021

Artificial intelligence tool enriches a gold-mine in cancer genomics

The fragments of cancer DNA analysed by the authors of this new study originate from the human genome, the sequence of which results from millions of years of evolution, and has been shaped by "copy-paste-edit" processes and co-evolution with parasitic elements.

22 Jul 2021

Study increases knowledge of the genetics behind aortic aneurysm

A new study increases knowledge of the genetics behind aortic aneurysm, a disease that can spark life-threatening events like aortic dissections and ruptures.

22 Jul 2021

'Good cholesterol' protects the liver from inflammation and injury, study shows

The body's so-called good cholesterol may be even better than we realize. New research from Washington University School of Medicine in St. Louis suggests that one type of high-density lipoprotein (HDL) has a previously unknown role in protecting the liver from injury.

22 Jul 2021

SARS-CoV-2 reprograms host chromatic network to induce immune dysfunction

A recent study conducted at the University of Texas Science Center, Houston, in the USA, has revealed that upon infection, SARS-CoV-2 alters the host chromatin architecture to suppress antiviral interferon-responsive genes and augment inflammatory genes. The study is currently available on the bioRxiv* preprint server.

22 Jul 2021

Can prior human seasonal coronavirus antibody response patterns predict SARS-CoV-2 inhibition?

A new study, recently released as a preprint on the medRxiv* server, reports the intriguing finding that the cross-neutralizing antibodies elicited by human seasonal coronaviruses (sCoVs) show varying ability to prevent binding between the SARS-CoV-2 spike antigen and its cognate receptor, the angiotensin-converting enzyme 2 (ACE2).

22 Jul 2021

Scientist explore conserved RNA elements as potential targets for anti-SARS-CoV-2 drugs

The study, published in the journal Angewandte Chemie International Edition, identified many small molecules that bind to certain parts of the SARS-CoV-2 genome that are less likely altered by mutations using dedicated substance libraries. The scientists derived key functional units and groups in ligands for effective and safe targeting of SARS-CoV-2 RNA.

22 Jul 2021

SARS-CoV-2 genomic surveillance identifies intricacies of stabilizing vs. destabilizing mutations

Some of these variants, known as variants of concern (VoC), have a much higher rate of transmission and increased mortality than the original SARS-CoV-2 strain. Therefore, it is imperative to assess the efficacy of the available vaccines against the circulating SARS-CoV-2 strains. In addition, tracking the continuously evolving genetic variants is also vital to prevent future outbreaks.

22 Jul 2021

Scientists seek to block pathogen’s most reliable weapon to cause severe malaria

The parasites that cause severe malaria are well-known for the sinister ways they infect humans, but new research may lead to drugs that could block one of their most reliable weapons: interference with the immune response.

21 Jul 2021

Vitamin C and TET proteins can work together to give regulatory T cells their life-saving power

You can't make a banana split without bananas. And you can't generate stable regulatory T cells without Vitamin C or enzymes called TET proteins, it appears.

21 Jul 2021

Study examines the host and viral factors that drive SARS-CoV-2 evolution

In a new paper recently uploaded to the preprint server bioRxiv*, two clinical isolates of SARS-CoV-2 are monitored by whole genome sequencing as they are passaged through several generations of Vero cells or human-derived primary nasal epithelial cells (PNEC), allowing direct observation of the occurrence of virus enhancing mutations and the way in which host cell factors shape virus evolution.

21 Jul 2021

Virginia Tech's in-house development of novel SARS-CoV-2 test shows the power of academic labs

In the early days of the pandemic, scientists at Virginia Tech created a COVID-19 testing laboratory and novel test for the virus from scratch.

21 Jul 2021

Scientists explore susceptibility of different animals to SARS-CoV-2 infection

A team of researchers at the Institute of Infectious Diseases (IFIK) at the University of Bern and the Institute of Virology and Immunology (IVI) has utilized a unique collection of advanced cell culture models of cells lining the airways from various domesticated and wildlife animals. This way, the team can determine which animals are susceptible to SARS-CoV-2 infection.

20 Jul 2021

Child with Bachmann-Bupp Syndrome successfully treated in just 16 months

Diagnosing a rare medical condition is difficult. Identifying a treatment for it can take years of trial and error. In a serendipitous intersection of research expertise, an ill patient in this case a child and innovative technology, Bachmann-Bupp Syndrome has gone from a list of symptoms to a successful treatment in just 16 months.

20 Jul 2021

Genome News and Research

CD8+ T cells show gene-dependent variation in cross-reactivity to human coronaviruses

Variations in human ACE2 genetics associated with coronavirus susceptibility

Study brings scientists one step closer to solving the mystery of aging

Researchers use mass spectrometry to study immunogenic SARS-CoV-2 epitopes

Clinical trials during a pandemic – lessons from COVID-19

Researchers develop a transferrable and integrative type I CRISPR-based platform to edit superbugs

Researchers identify an unexpected effect for already characterized active substances

Artificial intelligence tool enriches a gold-mine in cancer genomics

Study increases knowledge of the genetics behind aortic aneurysm

'Good cholesterol' protects the liver from inflammation and injury, study shows

SARS-CoV-2 reprograms host chromatic network to induce immune dysfunction

Can prior human seasonal coronavirus antibody response patterns predict SARS-CoV-2 inhibition?

Scientist explore conserved RNA elements as potential targets for anti-SARS-CoV-2 drugs

SARS-CoV-2 genomic surveillance identifies intricacies of stabilizing vs. destabilizing mutations

Scientists seek to block pathogen’s most reliable weapon to cause severe malaria

Vitamin C and TET proteins can work together to give regulatory T cells their life-saving power

Study examines the host and viral factors that drive SARS-CoV-2 evolution

Virginia Tech's in-house development of novel SARS-CoV-2 test shows the power of academic labs

Scientists explore susceptibility of different animals to SARS-CoV-2 infection

Child with Bachmann-Bupp Syndrome successfully treated in just 16 months

The art of CRISPR: The power and promise of gene editing eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

Latest News