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Potential new treatment approach to fatal COVID-19

Researchers from the University of Colorado Anschutz Medical Campus and Pathways Bioscience in the United States have found that activating a transcription factor involved in oxidative stress regulation, antiviral activity, and inflammation may serve as a new treatment approach to coronavirus disease 2019 (COVID-19).

18 May 2020

Novel insights on SARS-CoV-2 cell entry may inform further vaccine and treatment development

A research group from Harvard Medical School reported two cryo-electron microscopy structures derived from a single preparation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein in their paper available on the preprint server bioRxiv. Understanding the nuances of prefusion and postfusion conformations shed light on viral cell entry and may, in turn, guide the development of vaccines and drugs.

18 May 2020

COVID-19 may lead to thrombosis in the lungs and subsequently multi organ failure

COVID-19, the disease caused by SARS-CoV-2, not only may lead to severe pneumonia but also to thrombosis in the lungs and, subsequently, to multi organ failure involving kidneys, liver and pancreas.

18 May 2020

People infected with hepatitis D are more prone to hepatocellular carcinoma

Of all the hepatitis viruses, D is the most poorly known.This small virus, which can only infect people already infected with Hepatitis B, has so far been little studied.

18 May 2020

Neuroscientists discover anti-aging molecule that repairs age-related DNA damage

MIT neuroscientists have discovered that an enzyme called HDAC1 is critical for repairing age-related DNA damage to genes involved in memory and other cognitive functions.

18 May 2020

Research explores how human enzymes could be used to exacerbate COVID-19

Centenary Institute researchers have examined the critical role of human enzymes and the coronavirus in a newly published scientific review article that explores potential strategies for COVID-19 disease treatment and management.

18 May 2020

Kawasaki disease outbreak in children with COVID-19

The ongoing COVID-19 pandemic has marched its way to almost all parts of the world, with hundreds of thousands of deaths and over 4.5 million cases as of May 15, 2020. One saving grace has been the apparent sparing of children, though the mortality in older people is quite high.

17 May 2020

Study explores the prevalence and underlying belief patterns associated with Drunkorexia

Mojito, appletini or a simple glass of fizz - they may take the edge off a busy day, but if you find yourself bingeing on more than a few, you could be putting your physical and mental health at risk according new research at the University of South Australia.

15 May 2020

Chasing the elusive dream of a COVID cure

Although scientists and stock markets have celebrated the approval for emergency use of remdesivir to treat COVID-19, a cure for the disease that has killed nearly 260,000 people remains a long way off — and might never arrive.

15 May 2020

CELLINK announces partnership with AstraZeneca to provide advanced 3D-bioprinted liver organoids

CELLINK, focused on the development and commercialization of innovative bioprinting technologies and bioinks, announced today that the company will collaborate with AstraZeneca to provide advanced 3D-bioprinted liver organoids for drug discovery purposes in cardiovascular, renal and metabolic diseases.

From CELLINK 15 May 2020

ACTG initiates clinical trial to evaluate treatment for COVID-19

The AIDS Clinical Trials Group, the world's largest and longest established HIV research network, today announced the initiation of ACTG 5395, a clinical trial to evaluate whether the drug combination hydroxychloroquine and azithromycin can prevent hospitalization and death from COVID-19 (which is caused by infection with the virus SARS-CoV-2).

14 May 2020

Anti-inflammatory drug may improve respiratory function in some severe COVID-19 cases

A small study in Greece found that the clinically approved anti-inflammatory drug anakinra, used to treat rheumatoid arthritis, improved respiratory function in patients with severe coronavirus disease 2019 (COVID-19).

14 May 2020

Repurposed drug normalizes body weight, reverses metabolic damage in obese mice

An off-label experiment in mice using disulfiram, which has been used to treat alcohol use disorder for more than 50 years, consistently normalized body weight and reversed metabolic damage in obese middle-aged mice of both sexes.

14 May 2020

A promising treatment for chronic inflammatory liver disease

Primary sclerosing cholangitis (PSC) is a rare, chronic, inflammatory disease of the bile ducts and is difficult to treat.

14 May 2020

New combination offers complete protection against malaria

This ingredient is an essential component of the malaria parasite, a protein known as RPL6, which makes the parasite "visible" to a type of immune cells, the T cells, in the liver.

14 May 2020

Low albumin levels could predict poor outcome in COVID-19

A Spanish study has revealed that COVID-19 patients who have a low level of albumin have a poorer outcome compared to those with normal levels of blood albumin. The study titled, “Low albumin levels are associated with poorer outcomes in a case series of COVID-19 patients in Spain: a retrospective cohort study,” was released prior to peer-review on the open-access preprint server site Medrxiv*.

13 May 2020

New treatment improves survival for people with common liver cancer

For the first time in over a decade, scientists have identified a first-line treatment that significantly improves survival for people with hepatocellular carcinoma, the most common type of liver cancer.

13 May 2020

Study uncovers how the body synthesizes triglycerides

Doctors regularly warn their patients that having high levels of triglycerides, a major dietary fat, can increase the risk of heart disease, diabetes, obesity and fatty liver disease.

13 May 2020

Researchers urge Ireland government to change recommendations for vitamin D supplements

A new publication from Dr Eamon Laird and Professor Rose Anne Kenny, School of Medicine, and the Irish Longitudinal Study on Ageing (TILDA), in collaboration with Professor Jon Rhodes at University of Liverpool, highlights the association between vitamin D levels and mortality from COVID-19.

13 May 2020

Exposure to fine particulate matter can increase mortality in young patients with certain cancers

An analysis of nearly 16,000 young patients with cancer in Utah revealed that exposure to fine particulate matter was associated with increased mortality at five and 10 years after diagnosis of certain cancers.

13 May 2020

Liver News and Research

Potential new treatment approach to fatal COVID-19

Novel insights on SARS-CoV-2 cell entry may inform further vaccine and treatment development

COVID-19 may lead to thrombosis in the lungs and subsequently multi organ failure

People infected with hepatitis D are more prone to hepatocellular carcinoma

Neuroscientists discover anti-aging molecule that repairs age-related DNA damage

Research explores how human enzymes could be used to exacerbate COVID-19

Kawasaki disease outbreak in children with COVID-19

Study explores the prevalence and underlying belief patterns associated with Drunkorexia

Chasing the elusive dream of a COVID cure

CELLINK announces partnership with AstraZeneca to provide advanced 3D-bioprinted liver organoids

ACTG initiates clinical trial to evaluate treatment for COVID-19

Anti-inflammatory drug may improve respiratory function in some severe COVID-19 cases

Repurposed drug normalizes body weight, reverses metabolic damage in obese mice

A promising treatment for chronic inflammatory liver disease

New combination offers complete protection against malaria

Low albumin levels could predict poor outcome in COVID-19

New treatment improves survival for people with common liver cancer

Study uncovers how the body synthesizes triglycerides

Researchers urge Ireland government to change recommendations for vitamin D supplements

Exposure to fine particulate matter can increase mortality in young patients with certain cancers

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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