Preclinical News and Research

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Advances in the field of MPI: an interview with Professor Kannan Krishnan

In around 2004, there was a Phillips paper that discussed a new imaging technique called MPI. At that time, I had an eager, promising graduate student named Matt Ferguson who wanted a project, so I asked him to take a look.

From Bruker BioSpin Group 1 Mar 2016

New combination treatment shows promise for treating acute myeloid leukaemia

Walter and Eliza Hall Institute researchers have discovered that the treatment of the most deadly form of blood cancer may be improved by combining two recently developed drugs.

1 Mar 2016

UAB researchers focus on five key areas to improve care of CVD patients

According to the Centers for Disease Control and Prevention, approximately 610,000 people die of heart disease in the United States every year — that's one in every four deaths. The impact of cardiovascular diseases is quite large.

28 Feb 2016

New drug shows promise against Huntington's disease

A drug that would be the first to target the cause of Huntington's disease (HD) is effective and safe when tested in mice and monkeys, according to data released today that will be presented at the American Academy of Neurology's 68th Annual Meeting in Vancouver, Canada, April 15 to 21, 2016.

27 Feb 2016

Moffitt researchers develop novel therapeutic strategy to keep resistant cells in check

Despite numerous advances in oncology since the War on Cancer began, many patients develop resistance to standard therapies and eventually relapse. Moffitt Cancer Center researchers hope to improve treatment outcomes with development of a novel therapeutic strategy, called adaptive therapy, which is based on evolutionary principals and aims to keep resistant cells in check by maintaining a population of chemo-sensitive cells.

25 Feb 2016

MR Solutions introduces new 3D in vivo confocal microscope for preclinical research

MR Solutions’ new 3D in vivo confocal microscope for use in preclinical research provides a magnification range of up to 1000 times, allowing researchers to examine cellular details within a live small animal eliminating the need for a surgical biopsy - saving time and substantially reducing costs.

From MR Solutions 24 Feb 2016

Ohio State researchers working on new way to treat drug-resistant cancer

Researchers at The Ohio State University are working on a new way to treat drug-resistant cancer that the ancient Greeks would approve of--only it's not a Trojan horse, but DNA that hides the invading force.

24 Feb 2016

New clinical trial focuses on respiratory drug ambroxol for treatment of Parkinson's disease

A medication approved to treat various respiratory diseases and that has demonstrated neuroprotective effects in preclinical studies is the focus of a new clinical trial for Parkinson's disease.

23 Feb 2016

Regulus reports net loss of $7.2 million for fourth quarter 2015

Regulus Therapeutics Inc., a biopharmaceutical company leading the discovery and development of innovative medicines targeting microRNAs, today reported financial results for the fourth quarter and full-year ended December 31, 2015 and provided a summary of recent corporate highlights.

23 Feb 2016

Newly developed intravital microscopy system proves safe for use in humans

A team of Roswell Park Cancer Institute researchers has developed and evaluated the first intravital microscopy system shown to be safe for use in humans. Writing in the journal Nature Communications, the scientists report that their proprietary technology enabled them, for the first time ever, to visualize tumor blood vessels in real time.

22 Feb 2016

FDA-approved Alzheimer's medications may help people quit smoking

Despite several safe drug therapies available to help smokers quit, three-quarters report relapsing within six months of a quit attempt. University of Pennsylvania researchers Rebecca Ashare and Heath Schmidt saw potential for a permanent cessation solution in a class of FDA-approved medications used to improve cognitive impairments from Alzheimer's disease.

19 Feb 2016

Is breast density really linked to breast cancer risk? An interview with Dr Wenlian Zhu

Breast is composed of fatty and dense glandular and fibrous tissues. Breast density is expressed as the fraction of a mammogram occupied by dense tissues.

19 Feb 2016

Parvus' novel therapeutic approach employing nanomedicines published in Nature

Parvus Therapeutics today announced the publication in Nature of a seminal paper describing the discovery and applications of a novel therapeutic approach employing nanomedicines, referred to as "Navacims"TM, to reprogram white blood cells to become regulatory cells capable of blunting autoimmune responses and restoring the equilibrium of the immune system.

19 Feb 2016

Revealing dynamic protein complexes with NMR: an interview with Elisar Barbar

Most proteins are involved in interactions with one or a few functional ligands, but some proteins, like light chain 8 (LC8), have numerous binding partners. LC8 interacts with more than 100 functionally different proteins, from viral proteins to motor proteins to proteins involved in cell division.

From Bruker BioSpin Group 18 Feb 2016

Corvidia Therapeutics secures $26 million in Series A financing

Corvidia Therapeutics, a biotechnology company focused on the development of precision cardiovascular therapies, announced today that it has raised $26 million in a Series A financing, co-led by seed-investor Sofinnova Partners, and Apple Tree Partners.

18 Feb 2016

New study could help explain critical shortcomings in stem cell-driven therapies for heart disease

With every heart attack, billions of cardiomyocytes, the contracting heart muscle cells that make the heart pump time after time over a lifetime, are lost which can lead to heart failure or injury. Stem cell-based replacement strategies could open new and much needed therapeutic avenues.

17 Feb 2016

Green tea compound has high potential as treatment for rheumatoid arthritis

Researchers at Washington State University in Spokane have identified a potential new approach to combating the joint pain, inflammation and tissue damage caused by rheumatoid arthritis.

17 Feb 2016

New vaccine strategy may curb addiction, prevent fatal overdoses

With use of synthetic opioid "designer drugs" on the rise, scientists from The Scripps Research Institute have a new strategy to curb addiction and even prevent fatal overdoses.

17 Feb 2016

Anti-biofilm compounds show promise against drug-resistant bacteria associated with hospital-acquired infections

Researchers at the University of Michigan Life Sciences Institute and School of Public Health have discovered a new class of anti-biofilm compounds derived from marine microorganisms that show promise against a drug-resistant bacterium commonly associated with hospital-acquired infections.

16 Feb 2016

TUM researchers make progress in bringing immunotherapy to fight against cancer, infectious diseases

The quest to bring immunotherapy into widespread clinical use against cancer and infectious diseases has made great strides in recent years.

15 Feb 2016

Preclinical News and Research

Advances in the field of MPI: an interview with Professor Kannan Krishnan

New combination treatment shows promise for treating acute myeloid leukaemia

UAB researchers focus on five key areas to improve care of CVD patients

New drug shows promise against Huntington's disease

Moffitt researchers develop novel therapeutic strategy to keep resistant cells in check

MR Solutions introduces new 3D in vivo confocal microscope for preclinical research

Ohio State researchers working on new way to treat drug-resistant cancer

New clinical trial focuses on respiratory drug ambroxol for treatment of Parkinson's disease

Regulus reports net loss of $7.2 million for fourth quarter 2015

Newly developed intravital microscopy system proves safe for use in humans

FDA-approved Alzheimer's medications may help people quit smoking

Is breast density really linked to breast cancer risk? An interview with Dr Wenlian Zhu

Parvus' novel therapeutic approach employing nanomedicines published in Nature

Revealing dynamic protein complexes with NMR: an interview with Elisar Barbar

Corvidia Therapeutics secures $26 million in Series A financing

New study could help explain critical shortcomings in stem cell-driven therapies for heart disease

Green tea compound has high potential as treatment for rheumatoid arthritis

New vaccine strategy may curb addiction, prevent fatal overdoses

Anti-biofilm compounds show promise against drug-resistant bacteria associated with hospital-acquired infections

TUM researchers make progress in bringing immunotherapy to fight against cancer, infectious diseases

New Approach Methodologies, the 3Rs and Multimodal Imaging in Preclinical Research - eBook eBook

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Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

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Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics