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Potent pan-β-CoV human monoclonal antibody has in vivo activity in multiple animal models

Researchers evaluated the efficacy of viral spike domain 2-specific human monoclonal antibodies delivered intranasally, against all beta coronaviruses in hamsters and mice.

11 Mar 2022

Researchers solve the structure of large signaling protein involved in emergence of blood cancers

Researchers led by Christopher Garcia of the Ludwig Center at Stanford University have solved the long-sought structure of a large signaling protein involved in responses to infection, inflammation, the generation of immune cells and when dysregulated by mutation - the emergence of blood cancers known as myeloproliferative neoplasms.

11 Mar 2022

Ribociclib plus endocrine therapy offers survival benefit for postmenopausal patients with metastatic breast cancer

A study led by researchers from The University of Texas MD Anderson Cancer Center showed a significant overall survival benefit with ribociclib plus endocrine therapy for postmenopausal patients with hormone receptor-positive (HR+) human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer.

10 Mar 2022

Tannic acid plays a role in inhibiting three key molecular pathways involved in SARS-CoV-2 infection

Professor Charles Ramassamy and his postdoctoral researcher Mohamed Haddad at Institut national de la recherche scientifique, in collaboration with scientists from Université de Montréal, McGill University, and Université du Québec à Montréal, believe that tannic acid plays a role in inhibiting three important molecular pathways involved in the SARS-CoV-2 infection.

10 Mar 2022

Natural SARS-CoV-2 infection-induced anti-spike antibody responses

Researchers demonstrated the anti-spike antibody response to SARS-CoV-2 infection and further estimated the acute SARS-CoV-2 infection-induced Ab activity against recently emerged variants like Omicron.

10 Mar 2022

Scientists identify a molecular regulator involved in resistance to breast cancer treatment

A team from the UNIGE has identified a potential target for restoring the efficacy of standard treatment in resistant patients.

10 Mar 2022

Cross-species infectivity of SARS-CoV-2 variants correlated with prevalence

New research discusses the role of mutations in the receptor-binding domain of the spike protein in the generation of antibody resistance and loss of vaccine efficacy.

10 Mar 2022

Study finds chimeric mRNA induces potent and broadly acting neutralizing antibodies against SARS-CoV-2 variants

Researchers explored strategies to develop an mRNA-based COVID-19 vaccine that could elicit safer and wider protection against SARS-CoV-2 variants of concern.

10 Mar 2022

Engineered SARS-CoV-2 immunogens elicit broadly neutralizing antibodies

New research describes a novel approach whereby SARS-2 antigens were analyzed for conserved sites that may be targeted by broadly neutralizing antibodies that will confer immunity to other Sarbecoviruses.

10 Mar 2022

Study isolated largest panel of β-CoV broadly neutralizing antibodies to date

Researchers isolated a large panel of broadly neutralizing antibodies from COVID-19 recovered-vaccinated donors.

10 Mar 2022

Association of benzodiazepines with SARS-CoV-2 positivity and clinical outcomes in three patient groups

A new study has evaluated the association of BZD use with the clinical outcomes of SARS-CoV-2 positive patients.

10 Mar 2022

Study reveals differential blood glycoprotein profiles in symptomatic and asymptomatic COVID-19 patients

A new study used glycoprotein profiling technology platform that couples high-resolution LC-MS for glycoprotein analysis in regards to COVID-19.

9 Mar 2022

CRIPSR identifies cell-type-specific ACE2 modifiers

Researchers compile a list of candidate genes to identify the surface abundance of functional regulators of ACE2.

9 Mar 2022

Pain neuron-derived peptide protects mice from endotoxic death by enhancing brain ATP production

Sepsis is a high-mortality disease that arises when the body's immune reaction to pathogens causes multi-organ defects.

9 Mar 2022

Elevated P2X7 receptor levels in COVID-19 patients correlate with disease severity

In a recent study posted to the bioRxiv preprint server, researchers demonstrated that the soluble P2X7 receptor is increased in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients. They also showed that the elevated P2X7 receptors correlated with coronavirus disease 2019 (COVID-19) severity.

9 Mar 2022

Receptor News and Research

Potent pan-β-CoV human monoclonal antibody has in vivo activity in multiple animal models

Researchers solve the structure of large signaling protein involved in emergence of blood cancers

Ribociclib plus endocrine therapy offers survival benefit for postmenopausal patients with metastatic breast cancer

Tannic acid plays a role in inhibiting three key molecular pathways involved in SARS-CoV-2 infection

Natural SARS-CoV-2 infection-induced anti-spike antibody responses

Scientists identify a molecular regulator involved in resistance to breast cancer treatment

Cross-species infectivity of SARS-CoV-2 variants correlated with prevalence

Study finds chimeric mRNA induces potent and broadly acting neutralizing antibodies against SARS-CoV-2 variants

Engineered SARS-CoV-2 immunogens elicit broadly neutralizing antibodies

Study isolated largest panel of β-CoV broadly neutralizing antibodies to date

Association of benzodiazepines with SARS-CoV-2 positivity and clinical outcomes in three patient groups

Study reveals differential blood glycoprotein profiles in symptomatic and asymptomatic COVID-19 patients

CRIPSR identifies cell-type-specific ACE2 modifiers

Pain neuron-derived peptide protects mice from endotoxic death by enhancing brain ATP production

Elevated P2X7 receptor levels in COVID-19 patients correlate with disease severity

Unusual partners are key to making more blood vessels

How will mutations change the SARS-CoV-2 spike protein in the future?

Study identifies new immune checkpoint that may be exploited for cancer treatment

Study evaluates heterologous vaccination scheme in children using two SARS-CoV-2 RBD protein vaccines

A promising approach for COVID-19 prophylaxis

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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